3A4O

Lyn kinase domain

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0004672	molecular_function	protein kinase activity
X	0004713	molecular_function	protein tyrosine kinase activity
X	0005524	molecular_function	ATP binding
X	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE STU X 902

Chain	Residue
X	LEU22
X	LEU143
X	VAL30
X	THR88
X	GLU89
X	TYR90
X	MET91
X	GLY94
X	SER95
X	ALA140

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	23
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGAGQFGEVWmGyynnstk...........VAVK

Chain	Residue	Details
X	LEU22-LYS44

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site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YIHrDLRAANVLV

Chain	Residue	Details
X	TYR132-VAL144

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
X	ASP136

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
X	LEU22
X	LYS44

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
X	TYR75
X	TYR85

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:18070987, ECO:0000269|PubMed:7935444

Chain	Residue	Details
X	TYR166

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:18577747

Chain	Residue	Details
X	TYR229

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195

Chain	Residue	Details
X	TYR242

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site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis, CSK and MATK => ECO:0000269|PubMed:18070987, ECO:0000269|PubMed:7935444, ECO:0000269|PubMed:9171348, ECO:0007744|PubMed:15592455, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195

Chain	Residue	Details
X	TYR277

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
X	ASP136
X	ALA140

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
X	ASP136
X	ARG138

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site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
X	ASP136
X	ARG138
X	ASN141

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