3A4G
Structure of cytochrome P450 vdh from Pseudonocardia autotrophica (trigonal crystal form)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006707 | biological_process | cholesterol catabolic process |
| A | 0008395 | molecular_function | steroid hydroxylase activity |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0020037 | molecular_function | heme binding |
| A | 0036199 | molecular_function | cholest-4-en-3-one 26-monooxygenase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047103 | molecular_function | 3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity |
| A | 0047748 | molecular_function | cholestanetetraol 26-dehydrogenase activity |
| A | 0047749 | molecular_function | cholestanetriol 26-monooxygenase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE HEM A 412 |
| Chain | Residue |
| A | PHE58 |
| A | THR241 |
| A | PRO287 |
| A | ARG289 |
| A | LEU312 |
| A | PHE339 |
| A | PHE340 |
| A | GLY341 |
| A | ILE344 |
| A | HIS345 |
| A | CYS347 |
| A | LYS65 |
| A | GLY349 |
| A | ALA353 |
| A | PG0420 |
| A | HOH508 |
| A | HOH763 |
| A | MET87 |
| A | ILE88 |
| A | HIS95 |
| A | ARG99 |
| A | ALA236 |
| A | GLY237 |
| A | THR240 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PG0 A 420 |
| Chain | Residue |
| A | ILE88 |
| A | LEU232 |
| A | HEM412 |
| A | HOH622 |
| A | HOH763 |
Functional Information from PROSITE/UniProt
| site_id | PS00086 |
| Number of Residues | 10 |
| Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGhGIHFCLG |
| Chain | Residue | Details |
| A | PHE340-GLY349 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: axial binding residue => ECO:0000250|UniProtKB:P0A512 |
| Chain | Residue | Details |
| A | CYS347 |
