2ZZA
Moritella profunda Dihydrofolate reductase complex with NADP+ and Folate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0044281 | biological_process | small molecule metabolic process |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0050661 | molecular_function | NADP binding |
| A | 0070401 | molecular_function | NADP+ binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004146 | molecular_function | dihydrofolate reductase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0044281 | biological_process | small molecule metabolic process |
| B | 0046452 | biological_process | dihydrofolate metabolic process |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046655 | biological_process | folic acid metabolic process |
| B | 0050661 | molecular_function | NADP binding |
| B | 0070401 | molecular_function | NADP+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NAP A 163 |
| Chain | Residue |
| A | ALA7 |
| A | ASN46 |
| A | THR47 |
| A | LEU63 |
| A | SER64 |
| A | ARG65 |
| A | ALA78 |
| A | ILE96 |
| A | GLY98 |
| A | ALA99 |
| A | THR100 |
| A | ALA8 |
| A | ILE101 |
| A | TYR102 |
| A | GLN104 |
| A | THR125 |
| A | FOL164 |
| A | HOH196 |
| A | HOH234 |
| A | HOH299 |
| A | HOH302 |
| A | HOH304 |
| A | ILE15 |
| A | HOH309 |
| B | ARG65 |
| B | NAP163 |
| B | HOH251 |
| A | GLY16 |
| A | ASN19 |
| A | LYS20 |
| A | MET21 |
| A | GLY44 |
| A | ARG45 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE FOL A 164 |
| Chain | Residue |
| A | ILE6 |
| A | ALA7 |
| A | ALA8 |
| A | MET21 |
| A | GLU28 |
| A | LEU29 |
| A | PHE32 |
| A | LYS33 |
| A | ARG58 |
| A | ILE96 |
| A | NAP163 |
| A | HOH172 |
| A | HOH237 |
| A | HOH293 |
| A | HOH302 |
| A | HOH318 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 1PE A 165 |
| Chain | Residue |
| A | ARG34 |
| A | PHE155 |
| B | ARG34 |
| B | TYR143 |
| B | PHE155 |
| site_id | AC4 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE NAP B 163 |
| Chain | Residue |
| A | ARG65 |
| A | NAP163 |
| A | HOH290 |
| B | ALA7 |
| B | ALA8 |
| B | ILE15 |
| B | GLY16 |
| B | LEU17 |
| B | ASN19 |
| B | LYS20 |
| B | MET21 |
| B | GLY44 |
| B | ARG45 |
| B | ASN46 |
| B | THR47 |
| B | SER50 |
| B | LEU63 |
| B | SER64 |
| B | ARG65 |
| B | ALA78 |
| B | ILE96 |
| B | GLY98 |
| B | ALA99 |
| B | THR100 |
| B | ILE101 |
| B | TYR102 |
| B | GLN104 |
| B | THR125 |
| B | FOL164 |
| B | HOH166 |
| B | HOH172 |
| B | HOH186 |
| B | HOH194 |
| B | HOH211 |
| B | HOH243 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE FOL B 164 |
| Chain | Residue |
| B | ILE96 |
| B | NAP163 |
| B | HOH167 |
| B | HOH181 |
| B | HOH193 |
| B | HOH243 |
| B | HOH267 |
| B | HOH279 |
| B | ILE6 |
| B | ALA7 |
| B | ALA8 |
| B | MET21 |
| B | GLU28 |
| B | LEU29 |
| B | PHE32 |
| B | LYS33 |
| B | LEU55 |
| B | ARG58 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGldnkMPWhlpa.ElqlFkraT |
| Chain | Residue | Details |
| A | VAL14-THR36 |
