2ZZA
Moritella profunda Dihydrofolate reductase complex with NADP+ and Folate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0005829 | cellular_component | cytosol |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0046452 | biological_process | dihydrofolate metabolic process |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046655 | biological_process | folic acid metabolic process |
A | 0050661 | molecular_function | NADP binding |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004146 | molecular_function | dihydrofolate reductase activity |
B | 0005829 | cellular_component | cytosol |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0046452 | biological_process | dihydrofolate metabolic process |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0046655 | biological_process | folic acid metabolic process |
B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 33 |
Details | BINDING SITE FOR RESIDUE NAP A 163 |
Chain | Residue |
A | ALA7 |
A | ASN46 |
A | THR47 |
A | LEU63 |
A | SER64 |
A | ARG65 |
A | ALA78 |
A | ILE96 |
A | GLY98 |
A | ALA99 |
A | THR100 |
A | ALA8 |
A | ILE101 |
A | TYR102 |
A | GLN104 |
A | THR125 |
A | FOL164 |
A | HOH196 |
A | HOH234 |
A | HOH299 |
A | HOH302 |
A | HOH304 |
A | ILE15 |
A | HOH309 |
B | ARG65 |
B | NAP163 |
B | HOH251 |
A | GLY16 |
A | ASN19 |
A | LYS20 |
A | MET21 |
A | GLY44 |
A | ARG45 |
site_id | AC2 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE FOL A 164 |
Chain | Residue |
A | ILE6 |
A | ALA7 |
A | ALA8 |
A | MET21 |
A | GLU28 |
A | LEU29 |
A | PHE32 |
A | LYS33 |
A | ARG58 |
A | ILE96 |
A | NAP163 |
A | HOH172 |
A | HOH237 |
A | HOH293 |
A | HOH302 |
A | HOH318 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE 1PE A 165 |
Chain | Residue |
A | ARG34 |
A | PHE155 |
B | ARG34 |
B | TYR143 |
B | PHE155 |
site_id | AC4 |
Number of Residues | 35 |
Details | BINDING SITE FOR RESIDUE NAP B 163 |
Chain | Residue |
A | ARG65 |
A | NAP163 |
A | HOH290 |
B | ALA7 |
B | ALA8 |
B | ILE15 |
B | GLY16 |
B | LEU17 |
B | ASN19 |
B | LYS20 |
B | MET21 |
B | GLY44 |
B | ARG45 |
B | ASN46 |
B | THR47 |
B | SER50 |
B | LEU63 |
B | SER64 |
B | ARG65 |
B | ALA78 |
B | ILE96 |
B | GLY98 |
B | ALA99 |
B | THR100 |
B | ILE101 |
B | TYR102 |
B | GLN104 |
B | THR125 |
B | FOL164 |
B | HOH166 |
B | HOH172 |
B | HOH186 |
B | HOH194 |
B | HOH211 |
B | HOH243 |
site_id | AC5 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE FOL B 164 |
Chain | Residue |
B | ILE96 |
B | NAP163 |
B | HOH167 |
B | HOH181 |
B | HOH193 |
B | HOH243 |
B | HOH267 |
B | HOH279 |
B | ILE6 |
B | ALA7 |
B | ALA8 |
B | MET21 |
B | GLU28 |
B | LEU29 |
B | PHE32 |
B | LYS33 |
B | LEU55 |
B | ARG58 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGldnkMPWhlpa.ElqlFkraT |
Chain | Residue | Details |
A | VAL14-THR36 |