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2ZW3

Structure of the connexin-26 gap junction channel at 3.5 angstrom resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0005243molecular_functiongap junction channel activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
A0005886cellular_componentplasma membrane
A0005921cellular_componentgap junction
A0005922cellular_componentconnexin complex
A0007154biological_processcell communication
A0007267biological_processcell-cell signaling
A0007605biological_processsensory perception of sound
A0010644biological_processcell communication by electrical coupling
A0016020cellular_componentmembrane
A0016264biological_processgap junction assembly
A0042802molecular_functionidentical protein binding
A0046872molecular_functionmetal ion binding
A0055085biological_processtransmembrane transport
A0070161cellular_componentanchoring junction
A1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
A1990349biological_processgap junction-mediated intercellular transport
B0005243molecular_functiongap junction channel activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
B0005886cellular_componentplasma membrane
B0005921cellular_componentgap junction
B0005922cellular_componentconnexin complex
B0007154biological_processcell communication
B0007267biological_processcell-cell signaling
B0007605biological_processsensory perception of sound
B0010644biological_processcell communication by electrical coupling
B0016020cellular_componentmembrane
B0016264biological_processgap junction assembly
B0042802molecular_functionidentical protein binding
B0046872molecular_functionmetal ion binding
B0055085biological_processtransmembrane transport
B0070161cellular_componentanchoring junction
B1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
B1990349biological_processgap junction-mediated intercellular transport
C0005243molecular_functiongap junction channel activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
C0005886cellular_componentplasma membrane
C0005921cellular_componentgap junction
C0005922cellular_componentconnexin complex
C0007154biological_processcell communication
C0007267biological_processcell-cell signaling
C0007605biological_processsensory perception of sound
C0010644biological_processcell communication by electrical coupling
C0016020cellular_componentmembrane
C0016264biological_processgap junction assembly
C0042802molecular_functionidentical protein binding
C0046872molecular_functionmetal ion binding
C0055085biological_processtransmembrane transport
C0070161cellular_componentanchoring junction
C1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
C1990349biological_processgap junction-mediated intercellular transport
D0005243molecular_functiongap junction channel activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
D0005886cellular_componentplasma membrane
D0005921cellular_componentgap junction
D0005922cellular_componentconnexin complex
D0007154biological_processcell communication
D0007267biological_processcell-cell signaling
D0007605biological_processsensory perception of sound
D0010644biological_processcell communication by electrical coupling
D0016020cellular_componentmembrane
D0016264biological_processgap junction assembly
D0042802molecular_functionidentical protein binding
D0046872molecular_functionmetal ion binding
D0055085biological_processtransmembrane transport
D0070161cellular_componentanchoring junction
D1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
D1990349biological_processgap junction-mediated intercellular transport
E0005243molecular_functiongap junction channel activity
E0005509molecular_functioncalcium ion binding
E0005515molecular_functionprotein binding
E0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
E0005886cellular_componentplasma membrane
E0005921cellular_componentgap junction
E0005922cellular_componentconnexin complex
E0007154biological_processcell communication
E0007267biological_processcell-cell signaling
E0007605biological_processsensory perception of sound
E0010644biological_processcell communication by electrical coupling
E0016020cellular_componentmembrane
E0016264biological_processgap junction assembly
E0042802molecular_functionidentical protein binding
E0046872molecular_functionmetal ion binding
E0055085biological_processtransmembrane transport
E0070161cellular_componentanchoring junction
E1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
E1990349biological_processgap junction-mediated intercellular transport
F0005243molecular_functiongap junction channel activity
F0005509molecular_functioncalcium ion binding
F0005515molecular_functionprotein binding
F0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
F0005886cellular_componentplasma membrane
F0005921cellular_componentgap junction
F0005922cellular_componentconnexin complex
F0007154biological_processcell communication
F0007267biological_processcell-cell signaling
F0007605biological_processsensory perception of sound
F0010644biological_processcell communication by electrical coupling
F0016020cellular_componentmembrane
F0016264biological_processgap junction assembly
F0042802molecular_functionidentical protein binding
F0046872molecular_functionmetal ion binding
F0055085biological_processtransmembrane transport
F0070161cellular_componentanchoring junction
F1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
F1990349biological_processgap junction-mediated intercellular transport
Functional Information from PROSITE/UniProt
site_idPS00407
Number of Residues14
DetailsCONNEXINS_1 Connexins signature 1. CNTlQPGCknVCYD
ChainResidueDetails
ACYS53-ASP66

site_idPS00408
Number of Residues17
DetailsCONNEXINS_2 Connexins signature 2. Cnaw.PCpntVDCFVSRP
ChainResidueDetails
ACYS169-PRO185

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues66
DetailsINTRAMEM: INTRAMEM => ECO:0000269|PubMed:26753910
ChainResidueDetails
AASP2-VAL13
BASP2-VAL13
CASP2-VAL13
DASP2-VAL13
EASP2-VAL13
FASP2-VAL13

site_idSWS_FT_FI2
Number of Residues366
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26753910
ChainResidueDetails
AASN14-ILE20
DASN14-ILE20
DVAL95-THR135
DCYS211-VAL226
EASN14-ILE20
EVAL95-THR135
ECYS211-VAL226
FASN14-ILE20
FVAL95-THR135
FCYS211-VAL226
AVAL95-THR135
ACYS211-VAL226
BASN14-ILE20
BVAL95-THR135
BCYS211-VAL226
CASN14-ILE20
CVAL95-THR135
CCYS211-VAL226

site_idSWS_FT_FI3
Number of Residues474
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:26753910
ChainResidueDetails
AGLY21-ALA40
CILE74-HIS94
CTYR136-VAL156
CVAL190-LEU210
DGLY21-ALA40
DILE74-HIS94
DTYR136-VAL156
DVAL190-LEU210
EGLY21-ALA40
EILE74-HIS94
ETYR136-VAL156
AILE74-HIS94
EVAL190-LEU210
FGLY21-ALA40
FILE74-HIS94
FTYR136-VAL156
FVAL190-LEU210
ATYR136-VAL156
AVAL190-LEU210
BGLY21-ALA40
BILE74-HIS94
BTYR136-VAL156
BVAL190-LEU210
CGLY21-ALA40

site_idSWS_FT_FI4
Number of Residues384
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:26753910
ChainResidueDetails
ALYS41-HIS73
EMET157-THR189
FLYS41-HIS73
FMET157-THR189
AMET157-THR189
BLYS41-HIS73
BMET157-THR189
CLYS41-HIS73
CMET157-THR189
DLYS41-HIS73
DMET157-THR189
ELYS41-HIS73

site_idSWS_FT_FI5
Number of Residues6
DetailsBINDING: in other chain => ECO:0000305|PubMed:26753910, ECO:0007744|PDB:5ER7
ChainResidueDetails
AGLU42
BGLU42
CGLU42
DGLU42
EGLU42
FGLU42

site_idSWS_FT_FI6
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305|PubMed:26753910, ECO:0007744|PDB:5ER7
ChainResidueDetails
AGLY45
EGLU47
FGLY45
FGLU47
AGLU47
BGLY45
BGLU47
CGLY45
CGLU47
DGLY45
DGLU47
EGLY45

238268

PDB entries from 2025-07-02

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