2ZSU

Crystal structure of spermidine synthase from Pyrococcus horikoshii OT3, P1 form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004766	molecular_function	spermidine synthase activity
A	0005737	cellular_component	cytoplasm
A	0006596	biological_process	polyamine biosynthetic process
A	0008295	biological_process	spermidine biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0003824	molecular_function	catalytic activity
B	0004766	molecular_function	spermidine synthase activity
B	0005737	cellular_component	cytoplasm
B	0006596	biological_process	polyamine biosynthetic process
B	0008295	biological_process	spermidine biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
C	0003824	molecular_function	catalytic activity
C	0004766	molecular_function	spermidine synthase activity
C	0005737	cellular_component	cytoplasm
C	0006596	biological_process	polyamine biosynthetic process
C	0008295	biological_process	spermidine biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
D	0003824	molecular_function	catalytic activity
D	0004766	molecular_function	spermidine synthase activity
D	0005737	cellular_component	cytoplasm
D	0006596	biological_process	polyamine biosynthetic process
D	0008295	biological_process	spermidine biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
E	0003824	molecular_function	catalytic activity
E	0004766	molecular_function	spermidine synthase activity
E	0005737	cellular_component	cytoplasm
E	0006596	biological_process	polyamine biosynthetic process
E	0008295	biological_process	spermidine biosynthetic process
E	0016740	molecular_function	transferase activity
E	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
F	0003824	molecular_function	catalytic activity
F	0004766	molecular_function	spermidine synthase activity
F	0005737	cellular_component	cytoplasm
F	0006596	biological_process	polyamine biosynthetic process
F	0008295	biological_process	spermidine biosynthetic process
F	0016740	molecular_function	transferase activity
F	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE AG3 A1001

Chain	Residue
A	GLU8
A	THR163
A	ASP164
A	TYR229
A	TRP233
A	TYR10
A	VAL52
A	GLN53
A	TYR62
A	HIS63
A	ASP87
A	ASP161
A	SER162

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE AG3 C1002

Chain	Residue
C	GLU8
C	TYR10
C	VAL52
C	GLN53
C	TYR62
C	HIS63
C	ASP87
C	ASP161
C	SER162
C	ASP164
C	TYR229
C	TRP233

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE AG3 E1003

Chain	Residue
E	GLU8
E	TYR10
E	VAL52
E	GLN53
E	TYR62
E	HIS63
E	ASP87
E	ASP161
E	SER162
E	ASP164
E	TYR229
E	TRP233
E	HOH1015

---

Functional Information from PROSITE/UniProt

site_id	PS01330
Number of Residues	14
Details	PABS_1 Polyamine biosynthesis (PABS) domain signature. VLIIGGGdGgaIrE

Chain	Residue	Details
A	VAL80-GLU93

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	699
Details	Domain: {"description":"PABS","evidences":[{"source":"HAMAP-Rule","id":"MF_00198","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00198","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of spermidine synthase from Pyrococcus horikoshII OT3.","authoringGroup":["RIKEN structural genomics initiative (RSGI)"]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00198","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of spermidine synthase from Pyrococcus horikoshII OT3.","authoringGroup":["RIKEN structural genomics initiative (RSGI)"]}},{"source":"PDB","id":"2E5W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00198","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of spermidine synthase from Pyrococcus horikoshII OT3.","authoringGroup":["RIKEN structural genomics initiative (RSGI)"]}},{"source":"PDB","id":"2E5W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---