2ZSU

Crystal structure of spermidine synthase from Pyrococcus horikoshii OT3, P1 form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004766	molecular_function	spermidine synthase activity
A	0005737	cellular_component	cytoplasm
A	0006596	biological_process	polyamine biosynthetic process
A	0008295	biological_process	spermidine biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0003824	molecular_function	catalytic activity
B	0004766	molecular_function	spermidine synthase activity
B	0005737	cellular_component	cytoplasm
B	0006596	biological_process	polyamine biosynthetic process
B	0008295	biological_process	spermidine biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
C	0003824	molecular_function	catalytic activity
C	0004766	molecular_function	spermidine synthase activity
C	0005737	cellular_component	cytoplasm
C	0006596	biological_process	polyamine biosynthetic process
C	0008295	biological_process	spermidine biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
D	0003824	molecular_function	catalytic activity
D	0004766	molecular_function	spermidine synthase activity
D	0005737	cellular_component	cytoplasm
D	0006596	biological_process	polyamine biosynthetic process
D	0008295	biological_process	spermidine biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
E	0003824	molecular_function	catalytic activity
E	0004766	molecular_function	spermidine synthase activity
E	0005737	cellular_component	cytoplasm
E	0006596	biological_process	polyamine biosynthetic process
E	0008295	biological_process	spermidine biosynthetic process
E	0016740	molecular_function	transferase activity
E	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
F	0003824	molecular_function	catalytic activity
F	0004766	molecular_function	spermidine synthase activity
F	0005737	cellular_component	cytoplasm
F	0006596	biological_process	polyamine biosynthetic process
F	0008295	biological_process	spermidine biosynthetic process
F	0016740	molecular_function	transferase activity
F	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE AG3 A1001

Chain	Residue
A	GLU8
A	THR163
A	ASP164
A	TYR229
A	TRP233
A	TYR10
A	VAL52
A	GLN53
A	TYR62
A	HIS63
A	ASP87
A	ASP161
A	SER162

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE AG3 C1002

Chain	Residue
C	GLU8
C	TYR10
C	VAL52
C	GLN53
C	TYR62
C	HIS63
C	ASP87
C	ASP161
C	SER162
C	ASP164
C	TYR229
C	TRP233

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE AG3 E1003

Chain	Residue
E	GLU8
E	TYR10
E	VAL52
E	GLN53
E	TYR62
E	HIS63
E	ASP87
E	ASP161
E	SER162
E	ASP164
E	TYR229
E	TRP233
E	HOH1015

---

Functional Information from PROSITE/UniProt

site_id	PS01330
Number of Residues	14
Details	PABS_1 Polyamine biosynthesis (PABS) domain signature. VLIIGGGdGgaIrE

Chain	Residue	Details
A	VAL80-GLU93

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00198, ECO:0000305|Ref.2

Chain	Residue	Details
A	ASP161
B	ASP161
C	ASP161
D	ASP161
E	ASP161
F	ASP161

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00198, ECO:0000269|Ref.2, ECO:0007744|PDB:2E5W

Chain	Residue	Details
A	GLN32
C	GLU107
C	ASP144
C	PRO168
D	GLN32
D	GLU107
D	ASP144
D	PRO168
E	GLN32
E	GLU107
E	ASP144
A	GLU107
E	PRO168
F	GLN32
F	GLU107
F	ASP144
F	PRO168
A	ASP144
A	PRO168
B	GLN32
B	GLU107
B	ASP144
B	PRO168
C	GLN32

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00198, ECO:0000305|Ref.2, ECO:0007744|PDB:2E5W

Chain	Residue	Details
A	HIS63
D	HIS63
D	ASP87
D	ASP161
E	HIS63
E	ASP87
E	ASP161
F	HIS63
F	ASP87
F	ASP161
A	ASP87
A	ASP161
B	HIS63
B	ASP87
B	ASP161
C	HIS63
C	ASP87
C	ASP161

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