2ZS1

Structural Basis for the Heterotropic and Homotropic Interactions of Invertebrate Giant Hemoglobin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005344	molecular_function	oxygen carrier activity
A	0005506	molecular_function	iron ion binding
A	0005576	cellular_component	extracellular region
A	0005833	cellular_component	hemoglobin complex
A	0015671	biological_process	oxygen transport
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0046872	molecular_function	metal ion binding
B	0005344	molecular_function	oxygen carrier activity
B	0005506	molecular_function	iron ion binding
B	0005576	cellular_component	extracellular region
B	0005833	cellular_component	hemoglobin complex
B	0015671	biological_process	oxygen transport
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0046872	molecular_function	metal ion binding
C	0005344	molecular_function	oxygen carrier activity
C	0005506	molecular_function	iron ion binding
C	0005576	cellular_component	extracellular region
C	0005833	cellular_component	hemoglobin complex
C	0015671	biological_process	oxygen transport
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0046872	molecular_function	metal ion binding
D	0005344	molecular_function	oxygen carrier activity
D	0005576	cellular_component	extracellular region
D	0015671	biological_process	oxygen transport
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE HEM A 200

Chain	Residue
A	LEU45
A	LEU99
A	ASN103
A	MET107
A	TYR131
A	ILE138
A	OXY201
A	GOL6001
A	HOH7009
A	HOH7094
A	HOH7109
A	PHE46
A	HOH7124
D	HIS91
D	GLN95
A	VAL49
A	HIS62
A	ARG65
A	ALA69
A	GLN93
A	HIS94
A	ARG97

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE OXY A 201

Chain	Residue
A	PHE32
A	PHE46
A	HIS62
A	VAL66
A	HEM200

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A6001

Chain	Residue
A	GLY48
A	ARG97
A	HEM200
A	HOH7159
D	HOH6136

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A6002

Chain	Residue
A	GLY40
A	SER41
A	ARG43
A	ALA44
A	HOH7022
A	HOH7092
A	HOH7113

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A6004

Chain	Residue
A	PHE104
A	ALA105
A	GLU132
A	ALA135
A	HOH7011
A	HOH7035
A	HOH7169

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A6005

Chain	Residue
A	GLN79
A	GLN80
A	ALA81
A	THR82
D	LEU62

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A7001

Chain	Residue
A	ARG4
A	LYS11
C	ARG27

---

site_id	AC8
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HEM B 200

Chain	Residue
B	LEU45
B	PHE46
B	ARG48
B	VAL49
B	HIS62
B	ARG65
B	LEU70
B	HIS94
B	ILE99
B	GLY103
B	TYR104
B	PHE107
B	OXY201
B	HOH5026
B	HOH5035
B	HOH5064
C	HIS93
C	GLN97

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE OXY B 201

Chain	Residue
B	TRP32
B	PHE46
B	HIS62
B	VAL66
B	HEM200

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B5002

Chain	Residue
B	ASP55
B	HOH5077
B	HOH5092
B	HOH5094
B	HOH5106
C	HOH327

---

site_id	BC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM C 200

Chain	Residue
C	HOH251
C	HOH306
C	HOH317
B	ARG89
B	GLN93
C	LEU49
C	PHE50
C	VAL53
C	HIS66
C	ARG69
C	HIS98
C	ARG101
C	HIS108
C	PHE109
C	MET112
C	ILE143
C	OXY201
C	HOH207
C	HOH222

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE OXY C 201

Chain	Residue
C	PHE36
C	PHE50
C	HIS66
C	VAL70
C	HEM200

---

site_id	BC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEM D 200

Chain	Residue
A	HIS89
A	GLN93
D	MET49
D	PHE50
D	PRO51
D	GLN64
D	ARG67
D	LEU92
D	GLN95
D	HIS96
D	ILE99
D	ALA106
D	VAL107
D	LEU110
D	ILE141
D	OXY201
D	HOH6033
D	HOH6106
D	HOH6126
D	HOH6140

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE OXY D 201

Chain	Residue
D	PHE36
D	PHE50
D	GLN64
D	VAL68
D	HEM200

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL D6003

Chain	Residue
D	GLU1
D	ARG5
D	THR80
D	ARG82

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL D6006

Chain	Residue
A	GLY19
A	ALA21
D	ASP16
D	ASN77

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	567
Details	Domain: {"description":"Globin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"description":"proximal binding residue"}

Chain

Residue

Details

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