2ZR2
Crystal structure of seryl-tRNA synthetase from Pyrococcus horikoshii complexed with ATP
Replaces: 2DQ1Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004828 | molecular_function | serine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006434 | biological_process | seryl-tRNA aminoacylation |
| A | 0016260 | biological_process | selenocysteine biosynthetic process |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004828 | molecular_function | serine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006434 | biological_process | seryl-tRNA aminoacylation |
| B | 0016260 | biological_process | selenocysteine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE AMP A1001 |
| Chain | Residue |
| A | ARG283 |
| A | SER373 |
| A | THR406 |
| A | ALA409 |
| A | SER411 |
| A | ARG412 |
| A | GLU285 |
| A | PHE297 |
| A | ARG298 |
| A | VAL299 |
| A | PHE302 |
| A | GLU370 |
| A | VAL371 |
| A | VAL372 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A2001 |
| Chain | Residue |
| A | SER183 |
| A | ARG184 |
| A | ALA289 |
| A | HIS300 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A2003 |
| Chain | Residue |
| A | LYS291 |
| A | ASP292 |
| A | THR293 |
| A | ARG298 |
| A | ARG369 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A2005 |
| Chain | Residue |
| A | PHE297 |
| A | ARG298 |
| A | ARG369 |
| A | GLU370 |
| A | ARG412 |
| A | HOH2011 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A2007 |
| Chain | Residue |
| A | ALA172 |
| A | ASP173 |
| A | PHE174 |
| A | ALA175 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE AMP B1002 |
| Chain | Residue |
| B | ARG283 |
| B | GLU285 |
| B | PHE297 |
| B | ARG298 |
| B | VAL299 |
| B | PHE302 |
| B | GLU370 |
| B | VAL371 |
| B | VAL372 |
| B | THR406 |
| B | ALA409 |
| B | SER411 |
| B | ARG412 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B2002 |
| Chain | Residue |
| B | SER183 |
| B | ARG184 |
| B | ALA289 |
| B | HIS300 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B2004 |
| Chain | Residue |
| B | LYS291 |
| B | ASP292 |
| B | THR293 |
| B | ARG298 |
| B | ARG369 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B2006 |
| Chain | Residue |
| B | PHE297 |
| B | ARG298 |
| B | ARG369 |
| B | GLU370 |
| B | ARG412 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00176 |
| Chain | Residue | Details |
| A | THR252 | |
| B | GLU306 | |
| B | GLU370 | |
| B | THR406 | |
| A | ARG283 | |
| A | VAL299 | |
| A | GLU306 | |
| A | GLU370 | |
| A | THR406 | |
| B | THR252 | |
| B | ARG283 | |
| B | VAL299 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1ses |
| Chain | Residue | Details |
| A | ASP292 | |
| A | ARG298 | |
| A | GLU285 | |
| A | ARG283 | |
| A | THR288 |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1ses |
| Chain | Residue | Details |
| B | ASP292 | |
| B | ARG298 | |
| B | GLU285 | |
| B | ARG283 | |
| B | THR288 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ses |
| Chain | Residue | Details |
| A | ARG283 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ses |
| Chain | Residue | Details |
| B | ARG283 |
