2ZPA

Crystal Structure of tRNA(Met) Cytidine Acetyltransferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0002101	biological_process	tRNA wobble cytosine modification
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0008080	molecular_function	N-acetyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0018205	biological_process	peptidyl-lysine modification
A	0051391	biological_process	tRNA acetylation
A	0051392	molecular_function	tRNA cytidine N4-acetyltransferase activity
A	0106162	molecular_function	mRNA cytidine N-acetyltransferase activity
A	0106226	molecular_function	peptide 2-hydroxyisobutyryltransferase activity
A	0140640	molecular_function	catalytic activity, acting on a nucleic acid
A	1904812	biological_process	rRNA acetylation involved in maturation of SSU-rRNA
A	1990883	molecular_function	18S rRNA cytidine N-acetyltransferase activity
B	0000049	molecular_function	tRNA binding
B	0002101	biological_process	tRNA wobble cytosine modification
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0008080	molecular_function	N-acetyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0018205	biological_process	peptidyl-lysine modification
B	0051391	biological_process	tRNA acetylation
B	0051392	molecular_function	tRNA cytidine N4-acetyltransferase activity
B	0106162	molecular_function	mRNA cytidine N-acetyltransferase activity
B	0106226	molecular_function	peptide 2-hydroxyisobutyryltransferase activity
B	0140640	molecular_function	catalytic activity, acting on a nucleic acid
B	1904812	biological_process	rRNA acetylation involved in maturation of SSU-rRNA
B	1990883	molecular_function	18S rRNA cytidine N-acetyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 801

Chain	Residue
B	ARG201
B	GLY202
B	ARG203
B	GLY204
B	LYS205
B	SER206
B	HOH979

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site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ACO A 700

Chain	Residue
A	ILE461
A	GLN468
A	ARG469
A	GLU470
A	GLY471
A	THR472
A	GLY473
A	ARG474
A	SER493
A	GLU499
A	ARG502
A	PHE503
A	ARG506
A	HOH875
A	HOH887
A	SER459
A	ARG460

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site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ACO B 701

Chain	Residue
B	LYS301
B	SER459
B	ILE461
B	ARG469
B	GLU470
B	GLY471
B	THR472
B	GLY473
B	ARG474
B	SER493
B	PHE494
B	LEU500
B	PHE503
B	ARG506
B	HOH906
B	HOH930

---

site_id	AC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ADP A 800

Chain	Residue
A	ALA172
A	GLY174
A	ALA175
A	PRO176
A	GLN180
A	ALA200
A	GLY202
A	ARG203
A	GLY204
A	LYS205
A	SER206
A	ALA207
A	GLN211
A	PHE236
A	ILE318
A	ARG319
A	HOH856
A	HOH908
A	HOH968

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01886","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19322199","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Site: {"description":"Important for lysine 2-hydroxyisobutyryltransferase activity","evidences":[{"source":"PubMed","id":"34903851","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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