2ZOC
Crystal structure of recombinant human annexin IV
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0001786 | molecular_function | phosphatidylserine binding |
| A | 0004859 | molecular_function | phospholipase inhibitor activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005544 | molecular_function | calcium-dependent phospholipid binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0007219 | biological_process | Notch signaling pathway |
| A | 0009986 | cellular_component | cell surface |
| A | 0010804 | biological_process | negative regulation of tumor necrosis factor-mediated signaling pathway |
| A | 0012506 | cellular_component | vesicle membrane |
| A | 0016020 | cellular_component | membrane |
| A | 0030855 | biological_process | epithelial cell differentiation |
| A | 0031012 | cellular_component | extracellular matrix |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0031965 | cellular_component | nuclear membrane |
| A | 0032717 | biological_process | negative regulation of interleukin-8 production |
| A | 0042589 | cellular_component | zymogen granule membrane |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0043124 | biological_process | negative regulation of canonical NF-kappaB signal transduction |
| A | 0048306 | molecular_function | calcium-dependent protein binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0051059 | molecular_function | NF-kappaB binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0140416 | molecular_function | transcription regulator inhibitor activity |
| B | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| B | 0001786 | molecular_function | phosphatidylserine binding |
| B | 0004859 | molecular_function | phospholipase inhibitor activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005544 | molecular_function | calcium-dependent phospholipid binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007165 | biological_process | signal transduction |
| B | 0007219 | biological_process | Notch signaling pathway |
| B | 0009986 | cellular_component | cell surface |
| B | 0010804 | biological_process | negative regulation of tumor necrosis factor-mediated signaling pathway |
| B | 0012506 | cellular_component | vesicle membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0030855 | biological_process | epithelial cell differentiation |
| B | 0031012 | cellular_component | extracellular matrix |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0031965 | cellular_component | nuclear membrane |
| B | 0032717 | biological_process | negative regulation of interleukin-8 production |
| B | 0042589 | cellular_component | zymogen granule membrane |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0043124 | biological_process | negative regulation of canonical NF-kappaB signal transduction |
| B | 0048306 | molecular_function | calcium-dependent protein binding |
| B | 0048471 | cellular_component | perinuclear region of cytoplasm |
| B | 0051059 | molecular_function | NF-kappaB binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0140416 | molecular_function | transcription regulator inhibitor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 501 |
| Chain | Residue |
| A | MET99 |
| A | GLY101 |
| A | GLY103 |
| A | ASP143 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 502 |
| Chain | Residue |
| A | GLY182 |
| A | LYS185 |
| A | GLY187 |
| A | GLU227 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA A 503 |
| Chain | Residue |
| A | THR228 |
| A | GLU233 |
| A | LYS225 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 504 |
| Chain | Residue |
| A | MET258 |
| A | GLY260 |
| A | GLY262 |
| A | ASP302 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 505 |
| Chain | Residue |
| B | MET99 |
| B | GLY101 |
| B | GLY103 |
| B | ASP143 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 506 |
| Chain | Residue |
| B | GLY182 |
| B | LYS185 |
| B | GLY187 |
| B | GLU227 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA B 507 |
| Chain | Residue |
| B | LYS225 |
| B | THR228 |
| B | GLU233 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 508 |
| Chain | Residue |
| B | MET258 |
| B | GLY260 |
| B | GLY262 |
| B | ASP302 |
Functional Information from PROSITE/UniProt
| site_id | PS00223 |
| Number of Residues | 53 |
| Details | ANNEXIN_1 Annexin repeat signature. GTdedaiisvLayRntaQrqEirtaYkstigrdLiddLkselsGnfeqvIvgM |
| Chain | Residue | Details |
| A | GLY31-MET83 | |
| A | GLY103-LEU155 | |
| A | GLY187-ILE239 | |
| A | GLY262-LEU314 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 142 |
| Details | Repeat: {"description":"Annexin 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 142 |
| Details | Repeat: {"description":"Annexin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 144 |
| Details | Repeat: {"description":"Annexin 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 142 |
| Details | Repeat: {"description":"Annexin 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P08132","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
