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2ZOC

Crystal structure of recombinant human annexin IV

Functional Information from GO Data
ChainGOidnamespacecontents
A0001786molecular_functionphosphatidylserine binding
A0004859molecular_functionphospholipase inhibitor activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005544molecular_functioncalcium-dependent phospholipid binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0006357biological_processregulation of transcription by RNA polymerase II
A0007165biological_processsignal transduction
A0007219biological_processNotch signaling pathway
A0009986cellular_componentcell surface
A0012506cellular_componentvesicle membrane
A0016020cellular_componentmembrane
A0030855biological_processepithelial cell differentiation
A0031410cellular_componentcytoplasmic vesicle
A0031965cellular_componentnuclear membrane
A0032088biological_processnegative regulation of NF-kappaB transcription factor activity
A0032717biological_processnegative regulation of interleukin-8 production
A0042589cellular_componentzymogen granule membrane
A0042802molecular_functionidentical protein binding
A0043066biological_processnegative regulation of apoptotic process
A0048306molecular_functioncalcium-dependent protein binding
A0048471cellular_componentperinuclear region of cytoplasm
A0051059molecular_functionNF-kappaB binding
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
B0001786molecular_functionphosphatidylserine binding
B0004859molecular_functionphospholipase inhibitor activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005544molecular_functioncalcium-dependent phospholipid binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0006357biological_processregulation of transcription by RNA polymerase II
B0007165biological_processsignal transduction
B0007219biological_processNotch signaling pathway
B0009986cellular_componentcell surface
B0012506cellular_componentvesicle membrane
B0016020cellular_componentmembrane
B0030855biological_processepithelial cell differentiation
B0031410cellular_componentcytoplasmic vesicle
B0031965cellular_componentnuclear membrane
B0032088biological_processnegative regulation of NF-kappaB transcription factor activity
B0032717biological_processnegative regulation of interleukin-8 production
B0042589cellular_componentzymogen granule membrane
B0042802molecular_functionidentical protein binding
B0043066biological_processnegative regulation of apoptotic process
B0048306molecular_functioncalcium-dependent protein binding
B0048471cellular_componentperinuclear region of cytoplasm
B0051059molecular_functionNF-kappaB binding
B0062023cellular_componentcollagen-containing extracellular matrix
B0070062cellular_componentextracellular exosome
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA A 501
ChainResidue
AMET99
AGLY101
AGLY103
AASP143

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA A 502
ChainResidue
AGLY182
ALYS185
AGLY187
AGLU227

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CA A 503
ChainResidue
ATHR228
AGLU233
ALYS225

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA A 504
ChainResidue
AMET258
AGLY260
AGLY262
AASP302

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA B 505
ChainResidue
BMET99
BGLY101
BGLY103
BASP143

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA B 506
ChainResidue
BGLY182
BLYS185
BGLY187
BGLU227

site_idAC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CA B 507
ChainResidue
BLYS225
BTHR228
BGLU233

site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA B 508
ChainResidue
BMET258
BGLY260
BGLY262
BASP302

Functional Information from PROSITE/UniProt
site_idPS00223
Number of Residues53
DetailsANNEXIN_1 Annexin repeat signature. GTdedaiisvLayRntaQrqEirtaYkstigrdLiddLkselsGnfeqvIvgM
ChainResidueDetails
AGLY31-MET83
AGLY103-LEU155
AGLY187-ILE239
AGLY262-LEU314

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:22814378
ChainResidueDetails
AALA2
BALA2

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P08132
ChainResidueDetails
ATHR7
BTHR7

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER12
BSER12

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS213
ALYS293
ALYS300
BLYS213
BLYS293
BLYS300

226707

PDB entries from 2024-10-30

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