2ZKJ
Crystal structure of human PDK4-ADP complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004740 | molecular_function | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006885 | biological_process | regulation of pH |
| A | 0008286 | biological_process | insulin receptor signaling pathway |
| A | 0009267 | biological_process | cellular response to starvation |
| A | 0010510 | biological_process | regulation of pyruvate decarboxylation to acetyl-CoA |
| A | 0010565 | biological_process | regulation of ketone metabolic process |
| A | 0010906 | biological_process | regulation of glucose metabolic process |
| A | 0033554 | biological_process | cellular response to stress |
| A | 0042304 | biological_process | regulation of fatty acid biosynthetic process |
| A | 0042593 | biological_process | glucose homeostasis |
| A | 0042594 | biological_process | response to starvation |
| A | 0045124 | biological_process | regulation of bone resorption |
| A | 0046320 | biological_process | regulation of fatty acid oxidation |
| A | 0071398 | biological_process | cellular response to fatty acid |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004740 | molecular_function | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006885 | biological_process | regulation of pH |
| B | 0008286 | biological_process | insulin receptor signaling pathway |
| B | 0009267 | biological_process | cellular response to starvation |
| B | 0010510 | biological_process | regulation of pyruvate decarboxylation to acetyl-CoA |
| B | 0010565 | biological_process | regulation of ketone metabolic process |
| B | 0010906 | biological_process | regulation of glucose metabolic process |
| B | 0033554 | biological_process | cellular response to stress |
| B | 0042304 | biological_process | regulation of fatty acid biosynthetic process |
| B | 0042593 | biological_process | glucose homeostasis |
| B | 0042594 | biological_process | response to starvation |
| B | 0045124 | biological_process | regulation of bone resorption |
| B | 0046320 | biological_process | regulation of fatty acid oxidation |
| B | 0071398 | biological_process | cellular response to fatty acid |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 500 |
| Chain | Residue |
| A | ASN258 |
| A | ADP501 |
| A | PO4502 |
| A | HOH521 |
| A | HOH597 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PO4 A 502 |
| Chain | Residue |
| A | GLY329 |
| A | PHE330 |
| A | GLY331 |
| A | TYR332 |
| A | GLY333 |
| A | MG500 |
| A | ADP501 |
| A | HOH597 |
| A | GLU254 |
| A | LYS257 |
| A | LEU327 |
| A | ALA328 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 500 |
| Chain | Residue |
| B | ASN258 |
| B | ADP501 |
| B | PO4502 |
| B | HOH506 |
| B | HOH517 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 B 502 |
| Chain | Residue |
| B | GLU254 |
| B | LYS257 |
| B | LEU327 |
| B | ALA328 |
| B | GLY331 |
| B | TYR332 |
| B | GLY333 |
| B | MG500 |
| B | ADP501 |
| B | HOH517 |
| site_id | AC5 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE ADP A 501 |
| Chain | Residue |
| A | ASN258 |
| A | ARG261 |
| A | ALA262 |
| A | ASP293 |
| A | VAL298 |
| A | LEU306 |
| A | TYR311 |
| A | SER312 |
| A | THR313 |
| A | ALA328 |
| A | GLY329 |
| A | PHE330 |
| A | GLY331 |
| A | GLY333 |
| A | LEU334 |
| A | THR358 |
| A | MG500 |
| A | PO4502 |
| A | HOH503 |
| A | HOH509 |
| A | HOH513 |
| A | HOH521 |
| A | HOH524 |
| A | HOH559 |
| site_id | AC6 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE ADP B 501 |
| Chain | Residue |
| B | ASN258 |
| B | ARG261 |
| B | ALA262 |
| B | ASP293 |
| B | VAL298 |
| B | LEU306 |
| B | TYR311 |
| B | SER312 |
| B | THR313 |
| B | ALA328 |
| B | GLY329 |
| B | PHE330 |
| B | GLY331 |
| B | GLY333 |
| B | LEU334 |
| B | THR358 |
| B | MG500 |
| B | PO4502 |
| B | HOH503 |
| B | HOH506 |
| B | HOH512 |
| B | HOH516 |
| B | HOH524 |
| B | HOH552 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18658136","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Site: {"description":"Interaction with the other subunit in the homodimer"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1jm6 |
| Chain | Residue | Details |
| A | GLU254 | |
| A | HIS250 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1jm6 |
| Chain | Residue | Details |
| B | GLU254 | |
| B | HIS250 |
