2ZKD
Crystal structure of the SRA domain of mouse Np95 in complex with hemi-methylated CpG DNA
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT A 1 |
| Chain | Residue |
| A | ASN421 |
| A | ARG457 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 2 |
| Chain | Residue |
| A | GLY428 |
| A | PRO430 |
| A | LEU607 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ALA468 | |
| A | ASP474 | |
| B | ALA468 | |
| B | ASP474 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Required to confer preferential recognition of cytosine over thymine => ECO:0000250 |
| Chain | Residue | Details |
| A | THR484 | |
| B | THR484 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Required to discriminate between hemimethylated DNA versus symmetrically methylated DNA |
| Chain | Residue | Details |
| A | ASN494 | |
| B | ASN494 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Required for affinity and specificity for 5-mCpG sequence |
| Chain | Residue | Details |
| A | ARG496 | |
| B | ARG496 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q96T88 |
| Chain | Residue | Details |
| A | SER404 | |
| B | SER404 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| A | SER519 | |
| B | SER519 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:Q96T88 |
| Chain | Residue | Details |
| A | LYS550 | |
| B | LYS550 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:Q96T88 |
| Chain | Residue | Details |
| A | LYS550 | |
| B | LYS550 |
