2ZK2

Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with glutathion conjugated 15-deoxy-delta12,14-prostaglandin J2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0004879	molecular_function	nuclear receptor activity
B	0005634	cellular_component	nucleus
B	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GSH A 1

Chain	Residue
A	ARG280
A	SER342
A	PTG477
A	ILE281
A	GLY284
A	CYS285
A	ARG288
A	GLU291
A	GLU295
A	LEU340
A	ILE341

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site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PTG A 477

Chain	Residue
A	GSH1
A	CYS285
A	SER289
A	ALA292
A	HIS323
A	ILE326
A	TYR327
A	MET329
A	LEU330
A	MET364
A	HIS449
A	LEU469
A	TYR473

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	265
Details	Domain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Motif: {"description":"9aaTAD","evidences":[{"source":"PubMed","id":"30468856","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9744270","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PRG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36737649","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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