2ZIF
Crystal Structure of TTHA0409, Putative DNA Modification Methylase from Thermus thermophilus HB8- Complexed with S-Adenosyl-L-Methionine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008170 | molecular_function | N-methyltransferase activity |
| A | 0009007 | molecular_function | site-specific DNA-methyltransferase (adenine-specific) activity |
| A | 0009307 | biological_process | DNA restriction-modification system |
| A | 0015667 | molecular_function | site-specific DNA-methyltransferase (cytosine-N4-specific) activity |
| B | 0003677 | molecular_function | DNA binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008170 | molecular_function | N-methyltransferase activity |
| B | 0009007 | molecular_function | site-specific DNA-methyltransferase (adenine-specific) activity |
| B | 0009307 | biological_process | DNA restriction-modification system |
| B | 0015667 | molecular_function | site-specific DNA-methyltransferase (cytosine-N4-specific) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE SAM A 298 |
| Chain | Residue |
| A | GLY27 |
| A | ALA244 |
| A | GLY245 |
| A | THR246 |
| A | GLY247 |
| A | THR248 |
| A | GLU264 |
| A | LEU265 |
| A | HOH323 |
| A | ASP28 |
| A | ALA29 |
| A | SER47 |
| A | PRO48 |
| A | PRO49 |
| A | PRO219 |
| A | PHE220 |
| A | PHE243 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE SAM B 298 |
| Chain | Residue |
| B | GLY27 |
| B | ASP28 |
| B | ALA29 |
| B | SER47 |
| B | PRO48 |
| B | PRO49 |
| B | PRO219 |
| B | PHE220 |
| B | PHE243 |
| B | ALA244 |
| B | GLY245 |
| B | THR246 |
| B | THR248 |
| B | GLU264 |
| B | LEU265 |
| B | HOH311 |
Functional Information from PROSITE/UniProt
| site_id | PS00093 |
| Number of Residues | 6 |
| Details | N4_MTASE N-4 cytosine-specific DNA methylases signature. VTSPPY |
| Chain | Residue | Details |
| A | VAL45-TYR50 |
