Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2ZI5

C4S dCK variant of dCK in complex with L-dA+UDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004136	molecular_function	deoxyadenosine kinase activity
A	0004137	molecular_function	deoxycytidine kinase activity
A	0004138	molecular_function	deoxyguanosine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006170	biological_process	dAMP biosynthetic process
A	0006220	biological_process	pyrimidine nucleotide metabolic process
A	0008144	molecular_function	obsolete drug binding
A	0009157	biological_process	deoxyribonucleoside monophosphate biosynthetic process
A	0009224	biological_process	CMP biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0019136	molecular_function	deoxynucleoside kinase activity
A	0032261	biological_process	purine nucleotide salvage
A	0042803	molecular_function	protein homodimerization activity
A	0043771	molecular_function	cytidine kinase activity
A	1901135	biological_process	carbohydrate derivative metabolic process
A	1901293	biological_process	nucleoside phosphate biosynthetic process
B	0000166	molecular_function	nucleotide binding
B	0004136	molecular_function	deoxyadenosine kinase activity
B	0004137	molecular_function	deoxycytidine kinase activity
B	0004138	molecular_function	deoxyguanosine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006139	biological_process	nucleobase-containing compound metabolic process
B	0006170	biological_process	dAMP biosynthetic process
B	0006220	biological_process	pyrimidine nucleotide metabolic process
B	0008144	molecular_function	obsolete drug binding
B	0009157	biological_process	deoxyribonucleoside monophosphate biosynthetic process
B	0009224	biological_process	CMP biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0019136	molecular_function	deoxynucleoside kinase activity
B	0032261	biological_process	purine nucleotide salvage
B	0042803	molecular_function	protein homodimerization activity
B	0043771	molecular_function	cytidine kinase activity
B	1901135	biological_process	carbohydrate derivative metabolic process
B	1901293	biological_process	nucleoside phosphate biosynthetic process
C	0000166	molecular_function	nucleotide binding
C	0004136	molecular_function	deoxyadenosine kinase activity
C	0004137	molecular_function	deoxycytidine kinase activity
C	0004138	molecular_function	deoxyguanosine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006139	biological_process	nucleobase-containing compound metabolic process
C	0006170	biological_process	dAMP biosynthetic process
C	0006220	biological_process	pyrimidine nucleotide metabolic process
C	0008144	molecular_function	obsolete drug binding
C	0009157	biological_process	deoxyribonucleoside monophosphate biosynthetic process
C	0009224	biological_process	CMP biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0019136	molecular_function	deoxynucleoside kinase activity
C	0032261	biological_process	purine nucleotide salvage
C	0042803	molecular_function	protein homodimerization activity
C	0043771	molecular_function	cytidine kinase activity
C	1901135	biological_process	carbohydrate derivative metabolic process
C	1901293	biological_process	nucleoside phosphate biosynthetic process
D	0000166	molecular_function	nucleotide binding
D	0004136	molecular_function	deoxyadenosine kinase activity
D	0004137	molecular_function	deoxycytidine kinase activity
D	0004138	molecular_function	deoxyguanosine kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006139	biological_process	nucleobase-containing compound metabolic process
D	0006170	biological_process	dAMP biosynthetic process
D	0006220	biological_process	pyrimidine nucleotide metabolic process
D	0008144	molecular_function	obsolete drug binding
D	0009157	biological_process	deoxyribonucleoside monophosphate biosynthetic process
D	0009224	biological_process	CMP biosynthetic process
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0019136	molecular_function	deoxynucleoside kinase activity
D	0032261	biological_process	purine nucleotide salvage
D	0042803	molecular_function	protein homodimerization activity
D	0043771	molecular_function	cytidine kinase activity
D	1901135	biological_process	carbohydrate derivative metabolic process
D	1901293	biological_process	nucleoside phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE UDP A 1301

Chain	Residue
A	ALA1031
A	PHE1242
A	LYS1243
A	ALA1032
A	GLY1033
A	LYS1034
A	SER1035
A	THR1036
A	ARG1188
A	ARG1192
A	ASP1241

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 3L1 A 1401

Chain	Residue
A	GLU1053
A	MET1085
A	TYR1086
A	PHE1096
A	GLN1097
A	ASP1133
A	PHE1137
A	TYR1204

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE UDP B 2301

Chain	Residue
B	ALA2031
B	ALA2032
B	GLY2033
B	LYS2034
B	SER2035
B	THR2036
B	ARG2188
B	ARG2192
B	ASP2241
B	PHE2242
B	LYS2243

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 3L1 B 2401

Chain	Residue
B	ILE2030
B	GLU2053
B	MET2085
B	TYR2086
B	PHE2096
B	GLN2097
B	ASP2133
B	PHE2137
B	TYR2204

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE UDP C 3301

Chain	Residue
C	ALA3031
C	ALA3032
C	GLY3033
C	LYS3034
C	SER3035
C	THR3036
C	GLU3127
C	ARG3188
C	ARG3192
C	ASP3241
C	PHE3242
C	LYS3243

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 3L1 C 3401

Chain	Residue
C	ILE3030
C	GLU3053
C	TYR3086
C	PHE3096
C	GLN3097
C	ARG3128
C	ASP3133
C	PHE3137
C	ILE3200
C	TYR3204

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE UDP D 4301

Chain	Residue
D	ALA4031
D	ALA4032
D	GLY4033
D	LYS4034
D	SER4035
D	THR4036
D	ARG4188
D	ARG4192
D	ASP4241
D	PHE4242
D	LYS4243

site_id	AC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 3L1 D 4401

Chain	Residue
D	ILE4030
D	GLU4053
D	TYR4086
D	PHE4096
D	GLN4097
D	ARG4128
D	ASP4133
D	PHE4137
D	ILE4200
D	TYR4204

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	80
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20637175","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 2ocp

Chain	Residue	Details
A	GLU1053
A	ARG1128

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 2ocp

Chain	Residue	Details
B	ARG2128
B	GLU2053

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 2ocp

Chain	Residue	Details
C	ARG3128
C	GLU3053

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 2ocp

Chain	Residue	Details
D	ARG4128
D	GLU4053

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)