2ZET
Crystal structure of the small GTPase Rab27B complexed with the Slp homology domain of Slac2-a/melanophilin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003925 | molecular_function | G protein activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005770 | cellular_component | late endosome |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005795 | cellular_component | Golgi stack |
| A | 0006887 | biological_process | exocytosis |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0016020 | cellular_component | membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017157 | biological_process | regulation of exocytosis |
| A | 0019003 | molecular_function | GDP binding |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0030140 | cellular_component | trans-Golgi network transport vesicle |
| A | 0030141 | cellular_component | secretory granule |
| A | 0030672 | cellular_component | synaptic vesicle membrane |
| A | 0031489 | molecular_function | myosin V binding |
| A | 0032585 | cellular_component | multivesicular body membrane |
| A | 0042470 | cellular_component | melanosome |
| A | 0042589 | cellular_component | zymogen granule membrane |
| A | 0045921 | biological_process | positive regulation of exocytosis |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048488 | biological_process | synaptic vesicle endocytosis |
| A | 0070382 | cellular_component | exocytic vesicle |
| A | 0071985 | biological_process | multivesicular body sorting pathway |
| A | 0099641 | biological_process | anterograde axonal protein transport |
| A | 1904115 | cellular_component | axon cytoplasm |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0003925 | molecular_function | G protein activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005770 | cellular_component | late endosome |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005795 | cellular_component | Golgi stack |
| B | 0006887 | biological_process | exocytosis |
| B | 0012505 | cellular_component | endomembrane system |
| B | 0016020 | cellular_component | membrane |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0017157 | biological_process | regulation of exocytosis |
| B | 0019003 | molecular_function | GDP binding |
| B | 0019904 | molecular_function | protein domain specific binding |
| B | 0030140 | cellular_component | trans-Golgi network transport vesicle |
| B | 0030141 | cellular_component | secretory granule |
| B | 0030672 | cellular_component | synaptic vesicle membrane |
| B | 0031489 | molecular_function | myosin V binding |
| B | 0032585 | cellular_component | multivesicular body membrane |
| B | 0042470 | cellular_component | melanosome |
| B | 0042589 | cellular_component | zymogen granule membrane |
| B | 0045921 | biological_process | positive regulation of exocytosis |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048488 | biological_process | synaptic vesicle endocytosis |
| B | 0070382 | cellular_component | exocytic vesicle |
| B | 0071985 | biological_process | multivesicular body sorting pathway |
| B | 0099641 | biological_process | anterograde axonal protein transport |
| B | 1904115 | cellular_component | axon cytoplasm |
| C | 0006886 | biological_process | intracellular protein transport |
| C | 0031267 | molecular_function | small GTPase binding |
| D | 0006886 | biological_process | intracellular protein transport |
| D | 0031267 | molecular_function | small GTPase binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 301 |
| Chain | Residue |
| C | CYS81 |
| C | CYS84 |
| C | CYS104 |
| C | CYS107 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 302 |
| Chain | Residue |
| C | CYS64 |
| C | CYS67 |
| C | CYS89 |
| C | CYS92 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 303 |
| Chain | Residue |
| C | PHE129 |
| C | LYS130 |
| C | ARG131 |
| C | LYS136 |
| A | ARG90 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 202 |
| Chain | Residue |
| A | THR23 |
| A | THR41 |
| A | GTP203 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 301 |
| Chain | Residue |
| D | CYS81 |
| D | CYS84 |
| D | CYS104 |
| D | CYS107 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 302 |
| Chain | Residue |
| D | CYS64 |
| D | CYS67 |
| D | CYS89 |
| D | CYS92 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 303 |
| Chain | Residue |
| B | ARG90 |
| D | LYS130 |
| D | ARG131 |
| D | LYS136 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 202 |
| Chain | Residue |
| B | THR23 |
| B | THR41 |
| B | GTP203 |
| site_id | AC9 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GTP A 203 |
| Chain | Residue |
| A | ASP17 |
| A | SER18 |
| A | GLY19 |
| A | VAL20 |
| A | GLY21 |
| A | LYS22 |
| A | THR23 |
| A | THR24 |
| A | PRO36 |
| A | LYS37 |
| A | PHE38 |
| A | THR40 |
| A | THR41 |
| A | GLY77 |
| A | ASN133 |
| A | LYS134 |
| A | ASP136 |
| A | LEU137 |
| A | SER163 |
| A | ALA164 |
| A | ALA165 |
| A | MG202 |
| site_id | BC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GTP B 203 |
| Chain | Residue |
| B | ASP17 |
| B | SER18 |
| B | GLY19 |
| B | VAL20 |
| B | GLY21 |
| B | LYS22 |
| B | THR23 |
| B | THR24 |
| B | PRO36 |
| B | LYS37 |
| B | PHE38 |
| B | THR40 |
| B | THR41 |
| B | GLY77 |
| B | ASN133 |
| B | LYS134 |
| B | ASP136 |
| B | LEU137 |
| B | SER163 |
| B | ALA164 |
| B | ALA165 |
| B | MG202 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 34 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18940604","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylthreonine","evidences":[{"source":"UniProtKB","id":"O00194","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 240 |
| Details | Domain: {"description":"RabBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00234","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 86 |
| Details | Zinc finger: {"description":"FYVE-type"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | LEU78 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| B | LEU78 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | GLY19 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| B | GLY19 |
