2Z5X

Crystal Structure of Human Monoamine Oxidase A with Harmine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0006576	biological_process	biogenic amine metabolic process
A	0006584	biological_process	catecholamine metabolic process
A	0008131	molecular_function	primary methylamine oxidase activity
A	0016491	molecular_function	oxidoreductase activity
A	0019607	biological_process	phenylethylamine catabolic process
A	0042420	biological_process	dopamine catabolic process
A	0042428	biological_process	serotonin metabolic process
A	0097621	molecular_function	monoamine oxidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	39
Details	BINDING SITE FOR RESIDUE FAD A 600

Chain	Residue
A	ILE19
A	GLY49
A	GLY50
A	ARG51
A	THR52
A	GLY66
A	GLY67
A	ALA68
A	TYR69
A	PRO243
A	ALA272
A	GLY20
A	ILE273
A	LEU277
A	TRP397
A	TYR402
A	CYS406
A	TYR407
A	GLY434
A	THR435
A	GLY443
A	TYR444
A	GLY22
A	MET445
A	ALA448
A	HOH704
A	HOH711
A	HOH717
A	HOH723
A	HOH725
A	HOH726
A	HOH727
A	HOH762
A	ILE23
A	SER24
A	LEU42
A	GLU43
A	ALA44
A	ARG45

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE HRM A 700

Chain	Residue
A	ILE180
A	ASN181
A	PHE208
A	GLN215
A	ILE335
A	LEU337
A	PHE352
A	TYR407
A	TYR444
A	HOH726
A	HOH746

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DCX A 1

Chain	Residue
A	TRP116
A	PRO118
A	TYR121
A	THR509

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DCX A 2

Chain	Residue
A	THR489
A	TRP491

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 701

Chain	Residue
A	ARG45
A	ASP46
A	ARG47
A	LYS395
A	GLU400
A	HOH790

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 702

Chain	Residue
A	TYR62
A	ASP64
A	TYR89
A	LYS218
A	PHE219
A	GLY222
A	ASP339
A	LYS341
A	HOH786
A	HOH875

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 3

Chain	Residue
A	ASN75
A	LEU78
A	ARG79
A	LYS82
A	PRO476
A	SER478
A	ASP480
A	HOH802
A	HOH879

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Anchor for type IV membrane protein"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Region: {"description":"Interaction with membrane phospholipid headgroups","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Important for substrate specificity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Important for catalytic activity"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P21396","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"S-8alpha-FAD cysteine","evidences":[{"source":"PubMed","id":"18391214","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BXS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Z5X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Z5Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1b5q

Chain	Residue	Details
A	GLY71

---