2YZK

Crystal structure of orotate phosphoribosyltransferase from Aeropyrum pernix

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004588	molecular_function	orotate phosphoribosyltransferase activity
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006222	biological_process	UMP biosynthetic process
A	0016757	molecular_function	glycosyltransferase activity
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0044205	biological_process	'de novo' UMP biosynthetic process
B	0000287	molecular_function	magnesium ion binding
B	0004588	molecular_function	orotate phosphoribosyltransferase activity
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006222	biological_process	UMP biosynthetic process
B	0016757	molecular_function	glycosyltransferase activity
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0044205	biological_process	'de novo' UMP biosynthetic process
C	0000287	molecular_function	magnesium ion binding
C	0004588	molecular_function	orotate phosphoribosyltransferase activity
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006222	biological_process	UMP biosynthetic process
C	0016757	molecular_function	glycosyltransferase activity
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0044205	biological_process	'de novo' UMP biosynthetic process
D	0000287	molecular_function	magnesium ion binding
D	0004588	molecular_function	orotate phosphoribosyltransferase activity
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006222	biological_process	UMP biosynthetic process
D	0016757	molecular_function	glycosyltransferase activity
D	0019856	biological_process	pyrimidine nucleobase biosynthetic process
D	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 B 646

Chain	Residue
B	SER20
B	THR117
B	THR118
B	GLY119
B	THR120
B	SER121
B	HOH267
B	HOH650
B	HOH656

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site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PO4 C 647

Chain	Residue
C	SER20
C	THR117
C	THR118
C	GLY119
C	THR120
C	SER121
C	HOH671
C	HOH681
C	HOH712
C	HOH715
C	HOH716

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01208

Chain	Residue	Details
A	ARG88
B	ARG145
C	ARG88
C	LYS92
C	HIS94
C	THR117
C	ARG145
D	ARG88
D	LYS92
D	HIS94
D	THR117
A	LYS92
D	ARG145
A	HIS94
A	THR117
A	ARG145
B	ARG88
B	LYS92
B	HIS94
B	THR117

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_01208

Chain	Residue	Details
A	ASP113
B	ASP113
C	ASP113
D	ASP113

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1oro

Chain	Residue	Details
A	LYS92

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1oro

Chain	Residue	Details
D	LYS92

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