2YY5
Crystal Structure of tryptophanyl-tRNA synthetase from Mycoplasma pneumoniae
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004830 | molecular_function | tryptophan-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006436 | biological_process | tryptophanyl-tRNA aminoacylation |
| A | 0016874 | molecular_function | ligase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004830 | molecular_function | tryptophan-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006436 | biological_process | tryptophanyl-tRNA aminoacylation |
| B | 0016874 | molecular_function | ligase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| C | 0004830 | molecular_function | tryptophan-tRNA ligase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006412 | biological_process | translation |
| C | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| C | 0006436 | biological_process | tryptophanyl-tRNA aminoacylation |
| C | 0016874 | molecular_function | ligase activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| D | 0004830 | molecular_function | tryptophan-tRNA ligase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006412 | biological_process | translation |
| D | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| D | 0006436 | biological_process | tryptophanyl-tRNA aminoacylation |
| D | 0016874 | molecular_function | ligase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1360 |
| Chain | Residue |
| B | HIS16 |
| B | ASN19 |
| B | LYS200 |
| B | SER202 |
| B | LYS203 |
| B | HOH1411 |
| B | HOH1471 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1361 |
| Chain | Residue |
| B | TYR133 |
| B | GLN155 |
| B | HIS158 |
| B | HOH1368 |
| B | HOH1471 |
| B | HOH1474 |
| B | GLN108 |
| B | LYS112 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1362 |
| Chain | Residue |
| A | HIS16 |
| A | ASN19 |
| A | LYS200 |
| A | SER202 |
| A | LYS203 |
| A | HOH1410 |
| A | HOH1482 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1363 |
| Chain | Residue |
| A | GLN108 |
| A | TYR133 |
| A | GLN155 |
| A | HIS158 |
| A | HOH1368 |
| A | HOH1482 |
| A | HOH1483 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1364 |
| Chain | Residue |
| D | HIS16 |
| D | ASN19 |
| D | LYS200 |
| D | SER202 |
| D | LYS203 |
| D | HOH1480 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1365 |
| Chain | Residue |
| D | GLN10 |
| D | GLN108 |
| D | LYS112 |
| D | TYR133 |
| D | GLN155 |
| D | HIS158 |
| D | HOH1419 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1366 |
| Chain | Residue |
| C | GLN108 |
| C | TYR133 |
| C | GLN155 |
| C | HIS158 |
| C | HOH1426 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1367 |
| Chain | Residue |
| C | HIS16 |
| C | ASN19 |
| C | LYS200 |
| C | SER202 |
| C | LYS203 |
| C | HOH1412 |
| site_id | AC9 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE WSA A 1350 |
| Chain | Residue |
| A | GLY8 |
| A | GLN10 |
| A | HIS16 |
| A | GLY18 |
| A | ASN19 |
| A | GLY22 |
| A | PHE39 |
| A | HIS44 |
| A | MET137 |
| A | ASP140 |
| A | GLY152 |
| A | ASP154 |
| A | GLN155 |
| A | THR188 |
| A | ASN189 |
| A | ARG190 |
| A | ILE191 |
| A | LYS200 |
| A | MET201 |
| A | LYS203 |
| A | HOH1468 |
| A | HOH1482 |
| site_id | BC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE WSA B 1351 |
| Chain | Residue |
| B | THR7 |
| B | GLY8 |
| B | GLN10 |
| B | HIS16 |
| B | GLY18 |
| B | ASN19 |
| B | GLY22 |
| B | HIS44 |
| B | MET137 |
| B | ASP140 |
| B | GLY152 |
| B | ASP154 |
| B | GLN155 |
| B | THR188 |
| B | ASN189 |
| B | ARG190 |
| B | ILE191 |
| B | LYS200 |
| B | MET201 |
| B | LYS203 |
| B | HOH1368 |
| B | HOH1400 |
| B | HOH1420 |
| B | HOH1471 |
| site_id | BC2 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE WSA C 1352 |
| Chain | Residue |
| C | GLY8 |
| C | GLN10 |
| C | HIS16 |
| C | GLY18 |
| C | ASN19 |
| C | GLY22 |
| C | PHE39 |
| C | HIS44 |
| C | MET137 |
| C | ASP140 |
| C | ILE141 |
| C | GLY152 |
| C | ASP154 |
| C | GLN155 |
| C | THR188 |
| C | ASN189 |
| C | ARG190 |
| C | ILE191 |
| C | LYS200 |
| C | MET201 |
| C | LYS203 |
| C | HOH1369 |
| C | HOH1419 |
| site_id | BC3 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE WSA D 1353 |
| Chain | Residue |
| D | THR7 |
| D | GLY8 |
| D | GLN10 |
| D | HIS16 |
| D | GLY18 |
| D | ASN19 |
| D | GLY22 |
| D | HIS44 |
| D | MET137 |
| D | ASP140 |
| D | GLY152 |
| D | ASP154 |
| D | GLN155 |
| D | THR188 |
| D | ASN189 |
| D | ARG190 |
| D | ILE191 |
| D | LYS200 |
| D | MET201 |
| D | LYS203 |
| D | HOH1373 |
| D | HOH1415 |
| D | HOH1420 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 32 |
| Details | Motif: {"description":"'HIGH' region","evidences":[{"source":"HAMAP-Rule","id":"MF_00140","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Motif: {"description":"'KMSKS' region","evidences":[{"source":"HAMAP-Rule","id":"MF_00140","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 44 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00140","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1d2r |
| Chain | Residue | Details |
| A | LYS200 | |
| A | LYS203 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1d2r |
| Chain | Residue | Details |
| B | LYS200 | |
| B | LYS203 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1d2r |
| Chain | Residue | Details |
| C | LYS200 | |
| C | LYS203 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1d2r |
| Chain | Residue | Details |
| D | LYS200 | |
| D | LYS203 |
