2YWB
Crystal structure of GMP synthetase from Thermus thermophilus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003921 | molecular_function | GMP synthase activity |
| A | 0003922 | molecular_function | GMP synthase (glutamine-hydrolyzing) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006177 | biological_process | GMP biosynthetic process |
| A | 0006541 | biological_process | glutamine metabolic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0044281 | biological_process | small molecule metabolic process |
| B | 0003921 | molecular_function | GMP synthase activity |
| B | 0003922 | molecular_function | GMP synthase (glutamine-hydrolyzing) activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006177 | biological_process | GMP biosynthetic process |
| B | 0006541 | biological_process | glutamine metabolic process |
| B | 0016874 | molecular_function | ligase activity |
| B | 0044281 | biological_process | small molecule metabolic process |
| C | 0003921 | molecular_function | GMP synthase activity |
| C | 0003922 | molecular_function | GMP synthase (glutamine-hydrolyzing) activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0006164 | biological_process | purine nucleotide biosynthetic process |
| C | 0006177 | biological_process | GMP biosynthetic process |
| C | 0006541 | biological_process | glutamine metabolic process |
| C | 0016874 | molecular_function | ligase activity |
| C | 0044281 | biological_process | small molecule metabolic process |
| D | 0003921 | molecular_function | GMP synthase activity |
| D | 0003922 | molecular_function | GMP synthase (glutamine-hydrolyzing) activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0006164 | biological_process | purine nucleotide biosynthetic process |
| D | 0006177 | biological_process | GMP biosynthetic process |
| D | 0006541 | biological_process | glutamine metabolic process |
| D | 0016874 | molecular_function | ligase activity |
| D | 0044281 | biological_process | small molecule metabolic process |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_00344 |
| Chain | Residue | Details |
| A | CYS78 | |
| B | CYS78 | |
| C | CYS78 | |
| D | CYS78 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00344 |
| Chain | Residue | Details |
| A | HIS164 | |
| A | GLU166 | |
| B | HIS164 | |
| B | GLU166 | |
| C | HIS164 | |
| C | GLU166 | |
| D | HIS164 | |
| D | GLU166 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00344 |
| Chain | Residue | Details |
| A | SER217 | |
| B | SER217 | |
| C | SER217 | |
| D | SER217 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| A | HIS164 | |
| A | GLU166 | |
| A | CYS78 |
| site_id | CSA10 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| B | ASP221 | |
| B | GLY51 | |
| B | HIS164 | |
| B | TYR79 | |
| B | GLU166 | |
| B | CYS78 |
| site_id | CSA11 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| C | ASP221 | |
| C | GLY51 | |
| C | HIS164 | |
| C | TYR79 | |
| C | GLU166 | |
| C | CYS78 |
| site_id | CSA12 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| D | ASP221 | |
| D | GLY51 | |
| D | HIS164 | |
| D | TYR79 | |
| D | GLU166 | |
| D | CYS78 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| D | HIS164 | |
| D | GLU166 | |
| D | CYS78 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| C | HIS164 | |
| C | GLU166 | |
| C | CYS78 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| B | HIS164 | |
| B | GLU166 | |
| B | CYS78 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| C | HIS164 | |
| C | CYS78 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| D | HIS164 | |
| D | CYS78 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| A | HIS164 | |
| A | CYS78 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| B | HIS164 | |
| B | CYS78 |
| site_id | CSA9 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| A | ASP221 | |
| A | GLY51 | |
| A | HIS164 | |
| A | TYR79 | |
| A | GLU166 | |
| A | CYS78 |
