2YQ5
Crystal Structure of D-isomer specific 2-hydroxyacid dehydrogenase from Lactobacillus delbrueckii ssp. bulgaricus: NAD complexed form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0008720 | molecular_function | D-lactate dehydrogenase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016614 | molecular_function | oxidoreductase activity, acting on CH-OH group of donors |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0051287 | molecular_function | NAD binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0008720 | molecular_function | D-lactate dehydrogenase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016614 | molecular_function | oxidoreductase activity, acting on CH-OH group of donors |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0051287 | molecular_function | NAD binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0008720 | molecular_function | D-lactate dehydrogenase activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016614 | molecular_function | oxidoreductase activity, acting on CH-OH group of donors |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0051287 | molecular_function | NAD binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0008720 | molecular_function | D-lactate dehydrogenase activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016614 | molecular_function | oxidoreductase activity, acting on CH-OH group of donors |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE NAD A 0 |
| Chain | Residue |
| A | ILE107 |
| A | HIS207 |
| A | THR208 |
| A | PRO209 |
| A | CYS235 |
| A | ALA236 |
| A | ARG237 |
| A | ASP261 |
| A | HIS298 |
| A | ALA300 |
| A | PHE301 |
| A | VAL156 |
| A | GLY157 |
| A | HIS158 |
| A | ILE159 |
| A | TYR177 |
| A | ASP178 |
| A | VAL179 |
| A | ALA180 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NAD B 0 |
| Chain | Residue |
| B | TYR102 |
| B | ILE107 |
| B | GLY155 |
| B | VAL156 |
| B | GLY157 |
| B | HIS158 |
| B | ILE159 |
| B | TYR177 |
| B | ASP178 |
| B | VAL179 |
| B | ALA180 |
| B | HIS207 |
| B | THR208 |
| B | PRO209 |
| B | CYS235 |
| B | ALA236 |
| B | ARG237 |
| B | ASP261 |
| B | HIS298 |
| B | ALA300 |
| B | PHE301 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE NAD C 0 |
| Chain | Residue |
| C | TYR102 |
| C | ILE107 |
| C | GLY155 |
| C | VAL156 |
| C | GLY157 |
| C | HIS158 |
| C | ILE159 |
| C | TYR177 |
| C | ASP178 |
| C | VAL179 |
| C | ALA180 |
| C | HIS207 |
| C | THR208 |
| C | PRO209 |
| C | CYS235 |
| C | ALA236 |
| C | ARG237 |
| C | ASP261 |
| C | HIS298 |
| C | ALA300 |
| C | PHE301 |
| C | HOH2001 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE NAD D 0 |
| Chain | Residue |
| D | TYR102 |
| D | ILE107 |
| D | GLY155 |
| D | VAL156 |
| D | GLY157 |
| D | HIS158 |
| D | ILE159 |
| D | TYR177 |
| D | ASP178 |
| D | ALA180 |
| D | HIS207 |
| D | THR208 |
| D | PRO209 |
| D | MET217 |
| D | CYS235 |
| D | ARG237 |
| D | ASP261 |
| D | HIS298 |
| D | ALA300 |
| D | PHE301 |
Functional Information from PROSITE/UniProt
| site_id | PS00670 |
| Number of Residues | 23 |
| Details | D_2_HYDROXYACID_DH_2 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. VLkeADIVsLHtPlfpsTenMiG |
| Chain | Residue | Details |
| A | VAL197-GLY219 |
| site_id | PS00671 |
| Number of Residues | 17 |
| Details | D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. MKkSaYLINcARGeLVD |
| Chain | Residue | Details |
| A | MET226-ASP242 |
