2YPN
Hydroxymethylbilane synthase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004418 | molecular_function | hydroxymethylbilane synthase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
A | 0006782 | biological_process | protoporphyrinogen IX biosynthetic process |
A | 0006783 | biological_process | heme biosynthetic process |
A | 0016740 | molecular_function | transferase activity |
A | 0018160 | biological_process | peptidyl-pyrromethane cofactor linkage |
A | 0033014 | biological_process | tetrapyrrole biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE DPM A 314 |
Chain | Residue |
A | SER81 |
A | ARG155 |
A | LEU169 |
A | ALA170 |
A | GLN198 |
A | GLY199 |
A | CYS242 |
A | HOH325 |
A | HOH328 |
A | HOH331 |
A | HOH342 |
A | LYS83 |
A | HOH343 |
A | HOH442 |
A | ASP84 |
A | THR127 |
A | SER128 |
A | SER129 |
A | ARG131 |
A | ARG132 |
A | LEU148 |
Functional Information from PROSITE/UniProt
site_id | PS00533 |
Number of Residues | 17 |
Details | PORPHOBILINOGEN_DEAM Porphobilinogen deaminase cofactor-binding site. ERaMntrLeGGCqVPIG |
Chain | Residue | Details |
A | GLU231-GLY247 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | MOD_RES: S-(dipyrrolylmethanemethyl)cysteine |
Chain | Residue | Details |
A | CYS242 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 7 |
Details | M-CSA 260 |
Chain | Residue | Details |
A | LYS83 | activator, electrostatic stabiliser, hydrogen bond donor |
A | ASP84 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
A | ARG131 | activator, electrostatic stabiliser, hydrogen bond donor |
A | ARG132 | activator, electrostatic stabiliser, hydrogen bond donor |
A | ARG149 | activator, electrostatic stabiliser |
A | ARG155 | activator, electrostatic stabiliser |
A | CYS242 | covalently attached |