2YOZ

Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, crystallized with 2'-AMPS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004113	molecular_function	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
A	0009214	biological_process	cyclic nucleotide catabolic process
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE OVE A 1379

Chain	Residue
A	TYR168
A	HOH2033
A	HOH2071
A	HOH2074
A	HIS230
A	THR232
A	PHE235
A	HIS309
A	THR311
A	PRO320
A	VAL321
A	THR323

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 1380

Chain	Residue
A	ARG348
A	LYS366

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE 1PE A 1381

Chain	Residue
A	ALA197
A	LYS200
A	SER353

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 1382

Chain	Residue
A	PHE198
A	THR271
A	PRO272
A	GLY357

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 1383

Chain	Residue
A	LYS223
A	ARG224
A	PRO225
A	HOH2073

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ACT A 1384

Chain	Residue
A	LYS262

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1385

Chain	Residue
A	TRP289
A	SER297
A	GLY305

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT A 1386

Chain	Residue
A	LYS370
A	HOH2094

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"22393399","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"22393399","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P13233","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---