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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2YNE

Plasmodium vivax N-myristoyltransferase in complex with a benzothiophene inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006499	biological_process	N-terminal protein myristoylation
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0046872	molecular_function	metal ion binding
B	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006499	biological_process	N-terminal protein myristoylation
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0046872	molecular_function	metal ion binding
C	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006499	biological_process	N-terminal protein myristoylation
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 999

Chain	Residue
A	GLU159
A	PHE281
A	TRP289
A	HOH2440

site_id	AC2
Number of Residues	39
Details	BINDING SITE FOR RESIDUE NHW A 1000

Chain	Residue
A	TYR95
A	VAL96
A	ASN161
A	PHE162
A	LEU163
A	CYS164
A	VAL165
A	ARG170
A	SER171
A	LYS172
A	ARG173
A	LEU174
A	ALA175
A	PRO176
A	THR183
A	ILE186
A	ASN187
A	TRP192
A	GLN193
A	ALA194
A	THR197
A	LEU202
A	TYR393
A	MG1412
A	HOH2001
A	HOH2002
A	HOH2258
A	HOH2266
A	HOH2499
A	HOH2500
A	HOH2501
A	HOH2502
A	HOH2503
A	HOH2504
A	TYR28
A	LYS29
A	PHE30
A	TRP31
A	ASN94

site_id	AC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE YNE A 1001

Chain	Residue
A	VAL96
A	GLU97
A	PHE105
A	TYR107
A	THR197
A	TYR211
A	HIS213
A	TYR315
A	SER319
A	TYR334
A	SER335
A	ASN365
A	ALA366
A	LEU367
A	LEU388
A	LEU409
A	LEU410
A	HOH2283
A	HOH2284
A	HOH2423

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS B 999

Chain	Residue
B	GLU159
B	PHE281
B	TRP289
B	HOH2408

site_id	AC5
Number of Residues	38
Details	BINDING SITE FOR RESIDUE NHW B 1000

Chain	Residue
B	HOH2463
B	HOH2464
B	HOH2465
B	HOH2466
B	HOH2467
B	HOH2468
B	TYR28
B	LYS29
B	PHE30
B	TRP31
B	ASN94
B	TYR95
B	VAL96
B	ASN161
B	PHE162
B	LEU163
B	CYS164
B	VAL165
B	ARG170
B	SER171
B	LYS172
B	ARG173
B	LEU174
B	ALA175
B	PRO176
B	THR183
B	ILE186
B	ASN187
B	TRP192
B	THR197
B	LEU202
B	TYR393
B	MG1411
B	HOH2001
B	HOH2002
B	HOH2244
B	HOH2250
B	HOH2251

site_id	AC6
Number of Residues	20
Details	BINDING SITE FOR RESIDUE YNE B 1001

Chain	Residue
B	VAL96
B	GLU97
B	PHE105
B	TYR107
B	THR197
B	TYR211
B	TYR315
B	SER319
B	TYR334
B	SER335
B	ASN365
B	ALA366
B	LEU367
B	LEU388
B	LEU409
B	LEU410
B	HOH2238
B	HOH2265
B	HOH2392
B	HOH2470

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS C 999

Chain	Residue
C	GLU159
C	PHE281
C	TRP289
C	HOH2338

site_id	AC8
Number of Residues	35
Details	BINDING SITE FOR RESIDUE NHW C 1000

Chain	Residue
C	TYR28
C	LYS29
C	PHE30
C	TRP31
C	ASN94
C	TYR95
C	ASN161
C	PHE162
C	LEU163
C	CYS164
C	VAL165
C	ARG170
C	SER171
C	LYS172
C	ARG173
C	LEU174
C	ALA175
C	PRO176
C	THR183
C	ASN187
C	TRP192
C	TYR196
C	THR197
C	LEU202
C	TYR393
C	MG1411
C	HOH2001
C	HOH2194
C	HOH2199
C	HOH2391
C	HOH2392
C	HOH2393
C	HOH2394
C	HOH2395
C	HOH2396

site_id	AC9
Number of Residues	20
Details	BINDING SITE FOR RESIDUE YNE C 1001

Chain	Residue
C	VAL96
C	GLU97
C	ASP98
C	PHE105
C	TYR107
C	THR197
C	TYR211
C	TYR315
C	TYR334
C	SER335
C	ASN365
C	ALA366
C	LEU367
C	LEU388
C	VAL408
C	LEU409
C	LEU410
C	HOH2214
C	HOH2326
C	HOH2397

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1411

Chain	Residue
A	ARG210
A	HOH2506
B	ARG210
B	LYS373

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1412

Chain	Residue
A	LEU169
A	SER171
A	LYS172
A	ARG173
A	LEU174
A	NHW1000

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 1411

Chain	Residue
C	LEU169
C	SER171
C	LYS172
C	ARG173
C	LEU174
C	NHW1000

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 1411

Chain	Residue
B	LEU169
B	SER171
B	LYS172
B	ARG173
B	LEU174
B	NHW1000

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1413

Chain	Residue
A	SER328
A	THR329

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 1414

Chain	Residue
A	LYS180
A	THR247
A	LEU248
A	ARG358
A	HOH2351

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 1412

Chain	Residue
B	LYS180
B	THR247
B	LEU248
B	ARG358

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 1412

Chain	Residue
C	LYS180
C	THR247
C	LEU248
C	ARG358

Functional Information from PROSITE/UniProt

site_id	PS00975
Number of Residues	9
Details	NMT_1 Myristoyl-CoA:protein N-myristoyltransferase signature 1. EVNFLCvHK

Chain	Residue	Details
A	GLU159-LYS167

site_id	PS00976
Number of Residues	7
Details	NMT_2 Myristoyl-CoA:protein N-myristoyltransferase signature 2. KFGeGDG

Chain	Residue	Details
A	LYS380-GLY386

246031

PDB entries from 2025-12-10

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