2YMK

Crystal structure of the hexameric anti-microbial peptide channel dermcidin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0008233	molecular_function	peptidase activity
A	0031640	biological_process	killing of cells of another organism
B	0005576	cellular_component	extracellular region
B	0008233	molecular_function	peptidase activity
B	0031640	biological_process	killing of cells of another organism
C	0005576	cellular_component	extracellular region
C	0008233	molecular_function	peptidase activity
C	0031640	biological_process	killing of cells of another organism

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1049

Chain	Residue
A	HIS38
A	ASP42
B	GLU5
B	ASP9

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1049

Chain	Residue
A	GLU5
A	ASP9
B	HIS38
B	ASP42

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1049

Chain	Residue
C	ASP9
C	HIS38
C	ASP42
C	GLU5

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 1050

Chain	Residue
A	ASP24
A	ASP28
A	HOH2003
B	LYS6
B	LYS20

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1050

Chain	Residue
B	ASP24
B	ASP28
B	HOH2002
B	HOH2009

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN C 1050

Chain	Residue
C	ASP24
C	ASP28
C	HOH2005

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	132
Details	TRANSMEM: Helical => ECO:0000305|PubMed:23426625

Chain	Residue	Details
A	SER2-SER46
B	SER2-SER46
C	SER2-SER46

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: in chain A => ECO:0000269|PubMed:23426625, ECO:0007744|PDB:2YMK

Chain	Residue	Details
A	GLU5
A	ASP9
B	GLU5
B	ASP9
C	GLU5
C	ASP9

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:23426625, ECO:0007744|PDB:2YMK

Chain	Residue	Details
A	ASP24
A	ASP28
B	ASP24
B	ASP28
C	ASP24
C	ASP28

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: in chain B => ECO:0000269|PubMed:23426625, ECO:0007744|PDB:2YMK

Chain	Residue	Details
A	HIS38
A	ASP42
B	HIS38
B	ASP42
C	HIS38
C	ASP42

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS6
B	LYS6
C	LYS6

---