2YL5
Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| D | 0005975 | biological_process | carbohydrate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 2042 |
| Chain | Residue |
| A | LYS642 |
| A | ASN710 |
| A | TYR959 |
| A | HOH3033 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 2043 |
| Chain | Residue |
| A | LYS764 |
| A | VAL765 |
| A | HOH3669 |
| A | HOH3670 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 2044 |
| Chain | Residue |
| A | TYR825 |
| A | GLY826 |
| A | HOH3264 |
| A | HOH3273 |
| A | GLN823 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 2045 |
| Chain | Residue |
| A | LYS840 |
| A | HOH3307 |
| A | HOH3310 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 2046 |
| Chain | Residue |
| A | THR897 |
| A | ASN898 |
| A | TRP901 |
| A | TYR902 |
| A | MET947 |
| A | LEU948 |
| A | SER949 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 2047 |
| Chain | Residue |
| A | GLU658 |
| A | ASN982 |
| A | ASN984 |
| A | HOH3038 |
| A | HOH3619 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 2048 |
| Chain | Residue |
| A | ARG641 |
| A | TRP951 |
| A | ASP953 |
| A | HOH3054 |
| A | HOH3672 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 2049 |
| Chain | Residue |
| A | GLY741 |
| A | HIS742 |
| A | THR768 |
| A | THR769 |
| A | GLU805 |
| A | ALA807 |
| A | ASN808 |
| A | ASP809 |
| A | HOH3673 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 2041 |
| Chain | Residue |
| B | TRP951 |
| B | HOH3019 |
| B | HOH3021 |
| B | HOH3541 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 2042 |
| Chain | Residue |
| B | LYS642 |
| B | ASN710 |
| B | TYR959 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 2043 |
| Chain | Residue |
| B | ASP804 |
| B | TRP872 |
| B | TYR902 |
| B | HOH3541 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG C 2041 |
| Chain | Residue |
| C | GLN823 |
| C | TYR825 |
| C | GLY826 |
| C | HOH3250 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 2042 |
| Chain | Residue |
| C | LYS642 |
| C | ASN710 |
| C | GLU958 |
| C | TYR959 |
| C | HOH3038 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 2043 |
| Chain | Residue |
| C | ASN833 |
| C | GLN862 |
| C | HOH3259 |
| C | HOH3268 |
| C | HOH3333 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO C 2044 |
| Chain | Residue |
| C | ASP804 |
| C | PHE849 |
| C | TRP872 |
| C | TYR902 |
| C | HOH3231 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO C 2045 |
| Chain | Residue |
| C | ALA760 |
| C | HIS761 |
| C | PHE762 |
| C | ASP771 |
| C | TYR806 |
| C | LEU824 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO C 2046 |
| Chain | Residue |
| C | MET838 |
| C | HOH3264 |
| C | HOH3278 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO C 2047 |
| Chain | Residue |
| C | THR720 |
| C | GLU724 |
| C | HOH3613 |
| site_id | CC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO D 2040 |
| Chain | Residue |
| D | ASP804 |
| D | PHE849 |
| D | TRP872 |
| D | TYR902 |
| D | TRP951 |
| D | HOH3230 |
| D | HOH3488 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO D 2041 |
| Chain | Residue |
| D | LYS756 |
| D | HOH3139 |
| D | HOH3489 |
| site_id | CC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO D 2042 |
| Chain | Residue |
| D | PRO909 |
| D | LYS917 |
| site_id | CC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO D 2043 |
| Chain | Residue |
| D | ALA1032 |
