2YCE

Structure of an Archaeal fructose-1,6-bisphosphate aldolase with the catalytic Lys covalently bound to the carbinolamine intermediate of the substrate.

Replaces:  1W8R

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004332	molecular_function	fructose-bisphosphate aldolase activity
A	0005737	cellular_component	cytoplasm
A	0006096	biological_process	glycolytic process
A	0016829	molecular_function	lyase activity
B	0004332	molecular_function	fructose-bisphosphate aldolase activity
B	0005737	cellular_component	cytoplasm
B	0006096	biological_process	glycolytic process
B	0016829	molecular_function	lyase activity
C	0004332	molecular_function	fructose-bisphosphate aldolase activity
C	0005737	cellular_component	cytoplasm
C	0006096	biological_process	glycolytic process
C	0016829	molecular_function	lyase activity
D	0004332	molecular_function	fructose-bisphosphate aldolase activity
D	0005737	cellular_component	cytoplasm
D	0006096	biological_process	glycolytic process
D	0016829	molecular_function	lyase activity
E	0004332	molecular_function	fructose-bisphosphate aldolase activity
E	0005737	cellular_component	cytoplasm
E	0006096	biological_process	glycolytic process
E	0016829	molecular_function	lyase activity
F	0004332	molecular_function	fructose-bisphosphate aldolase activity
F	0005737	cellular_component	cytoplasm
F	0006096	biological_process	glycolytic process
F	0016829	molecular_function	lyase activity
G	0004332	molecular_function	fructose-bisphosphate aldolase activity
G	0005737	cellular_component	cytoplasm
G	0006096	biological_process	glycolytic process
G	0016829	molecular_function	lyase activity
H	0004332	molecular_function	fructose-bisphosphate aldolase activity
H	0005737	cellular_component	cytoplasm
H	0006096	biological_process	glycolytic process
H	0016829	molecular_function	lyase activity
I	0004332	molecular_function	fructose-bisphosphate aldolase activity
I	0005737	cellular_component	cytoplasm
I	0006096	biological_process	glycolytic process
I	0016829	molecular_function	lyase activity
J	0004332	molecular_function	fructose-bisphosphate aldolase activity
J	0005737	cellular_component	cytoplasm
J	0006096	biological_process	glycolytic process
J	0016829	molecular_function	lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE M2P A 270

Chain	Residue
A	ALA22
A	GLY203
A	GLY204
A	ALA229
A	VAL230
A	GLY231
A	ARG232
A	HOH2078
A	HOH2079
A	HOH2154
A	HOH2155
A	ASP24
A	HOH2156
A	HOH2157
A	HOH2158
A	HIS25
A	HIS29
A	TRP144
A	ARG148
A	LYS177
A	LYS179
A	SER202

---

site_id	AC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE M2P B 270

Chain	Residue
B	ALA22
B	ASP24
B	HIS25
B	HIS29
B	TRP144
B	ARG148
B	LYS177
B	LYS179
B	SER202
B	GLY203
B	GLY204
B	ALA229
B	VAL230
B	GLY231
B	ARG232
B	HOH2084
B	HOH2085
B	HOH2170
B	HOH2171
B	HOH2172
B	HOH2173

---

site_id	AC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE M2P C 270

Chain	Residue
C	ALA22
C	ASP24
C	HIS25
C	HIS29
C	TRP144
C	ARG148
C	LYS177
C	LYS179
C	SER202
C	GLY203
C	GLY204
C	ALA229
C	VAL230
C	GLY231
C	ARG232
C	HOH2077
C	HOH2133
C	HOH2134
C	HOH2135
C	HOH2136

---

site_id	AC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE M2P D 270

Chain	Residue
D	ALA22
D	ASP24
D	HIS25
D	HIS29
D	TRP144
D	ARG148
D	LYS177
D	LYS179
D	SER202
D	GLY203
D	GLY204
D	ALA229
D	VAL230
D	GLY231
D	ARG232
D	HOH2070
D	HOH2071
D	HOH2124
D	HOH2125
D	HOH2126

---

site_id	AC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE M2P E 270

Chain	Residue
E	HOH2093
E	HOH2170
E	HOH2171
E	HOH2173
E	ALA22
E	ASP24
E	HIS25
E	HIS29
E	TRP144
E	ARG148
E	LYS177
E	LYS179
E	SER202
E	GLY203
E	GLY204
E	ALA229
E	VAL230
E	GLY231
E	ARG232
E	HOH2092

---

site_id	AC6
Number of Residues	21
Details	BINDING SITE FOR RESIDUE M2P F 270

Chain	Residue
F	ALA22
F	ASP24
F	HIS25
F	HIS29
F	TRP144
F	PHE146
F	ARG148
F	LYS177
F	LYS179
F	SER202
F	GLY203
F	GLY204
F	ALA229
F	VAL230
F	GLY231
F	ARG232
F	HOH2062
F	HOH2063
F	HOH2120
F	HOH2121
F	HOH2122

---

site_id	AC7
Number of Residues	22
Details	BINDING SITE FOR RESIDUE M2P G 270

Chain	Residue
G	ALA22
G	ASP24
G	HIS25
G	HIS29
G	TRP144
G	PHE146
G	ARG148
G	LYS177
G	LYS179
G	SER202
G	GLY203
G	GLY204
G	ALA229
G	VAL230
G	GLY231
G	ARG232
G	HOH2080
G	HOH2081
G	HOH2145
G	HOH2146
G	HOH2147
G	HOH2148

---

site_id	AC8
Number of Residues	21
Details	BINDING SITE FOR RESIDUE M2P H 270

Chain	Residue
H	ALA22
H	ASP24
H	HIS25
H	HIS29
H	TRP144
H	ARG148
H	LYS177
H	LYS179
H	SER202
H	GLY203
H	GLY204
H	ALA229
H	VAL230
H	GLY231
H	ARG232
H	HOH2073
H	HOH2074
H	HOH2147
H	HOH2148
H	HOH2149
H	HOH2150

---

site_id	AC9
Number of Residues	21
Details	BINDING SITE FOR RESIDUE M2P I 270

Chain	Residue
I	ALA22
I	ASP24
I	HIS25
I	HIS29
I	TRP144
I	ARG148
I	LYS177
I	LYS179
I	SER202
I	GLY203
I	GLY204
I	ALA229
I	VAL230
I	GLY231
I	ARG232
I	HOH2084
I	HOH2085
I	HOH2151
I	HOH2156
I	HOH2157
I	HOH2158

---

site_id	BC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE M2P J 270

Chain	Residue
J	ASP24
J	HIS25
J	HIS29
J	TRP144
J	ARG148
J	LYS177
J	LYS179
J	SER202
J	GLY203
J	GLY204
J	ALA229
J	VAL230
J	GLY231
J	ARG232
J	HOH2087
J	HOH2089
J	HOH2171
J	HOH2172
J	HOH2173
J	HOH2174

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Active site: {"description":"Proton donor"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	10
Details	Active site: {"description":"Schiff-base intermediate with dihydroxyacetone-P"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	100
Details	Binding site: {}

Chain

Residue

Details

---