2YB0

The Crystal Structure of Leishmania major dUTPase in complex deoxyuridine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004170	molecular_function	dUTP diphosphatase activity
A	0005654	cellular_component	nucleoplasm
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0004170	molecular_function	dUTP diphosphatase activity
B	0005654	cellular_component	nucleoplasm
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
D	0004170	molecular_function	dUTP diphosphatase activity
D	0005654	cellular_component	nucleoplasm
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding
E	0004170	molecular_function	dUTP diphosphatase activity
E	0005654	cellular_component	nucleoplasm
E	0016787	molecular_function	hydrolase activity
E	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE DUR A 1266

Chain	Residue
A	GLN21
A	ASN183
A	SO41267
A	HOH2029
B	TRP60
B	TRP61
A	LEU24
A	ASN25
A	ILE28
A	TRP41
A	GLU48
A	ASP79
A	HIS82
A	PHE83

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 1267

Chain	Residue
A	ARG186
A	TYR191
A	LYS198
A	DUR1266
A	HOH2006
A	HOH2038
B	LYS59
B	TRP61
B	LYS62

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1268

Chain	Residue
A	SO41269
A	HOH2039
B	LYS59
B	LYS62
B	ASN63

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1269

Chain	Residue
A	VAL197
A	LYS198
A	VAL199
A	SO41268
B	LYS62

---

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE DUR B 1266

Chain	Residue
A	TRP60
A	TRP61
B	GLN21
B	LEU24
B	ASN25
B	ILE28
B	TRP41
B	ASP79
B	HIS82
B	PHE83
B	ASN183
B	SO41267
B	HOH2015
B	HOH2018

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 B 1267

Chain	Residue
A	LYS59
A	TRP61
A	LYS62
B	ARG186
B	TYR191
B	LYS198
B	DUR1266
B	SO41268
B	HOH2019

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 1268

Chain	Residue
A	LYS59
A	LYS62
A	ASN63
B	SO41267

---

site_id	AC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE DUR D 1266

Chain	Residue
D	GLN21
D	LEU24
D	ASN25
D	ILE28
D	TRP41
D	ASP79
D	HIS82
D	PHE83
D	ASN183
D	ARG186
D	SO41267
E	TRP60
E	TRP61

---

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 D 1267

Chain	Residue
D	ARG186
D	TYR191
D	LYS198
D	DUR1266
D	HOH2023
E	LYS59
E	TRP61
E	LYS62

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 1268

Chain	Residue
E	LYS59
E	LYS62
E	ASN63

---

site_id	BC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE DUR E 1266

Chain	Residue
D	TRP60
D	TRP61
E	GLN21
E	LEU24
E	ASN25
E	ILE28
E	TRP41
E	ASP79
E	HIS82
E	PHE83
E	ASN183
E	SO41267
E	HOH2011

---

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 E 1267

Chain	Residue
D	LYS62
E	ARG186
E	TYR191
E	LYS198
E	DUR1266
E	HOH2015
D	LYS59
D	TRP61

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 1268

Chain	Residue
D	LYS59
D	LYS62
D	ASN63

---