2YA0

Catalytic Module of the Multi-modular glycogen-degrading pneumococcal virulence factor SpuA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0005975	biological_process	carbohydrate metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 1696

Chain	Residue
A	SER206
A	TYR208
A	ASP537
A	HOH2106
A	HOH2332
A	HOH2372
A	HOH2676

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1697

Chain	Residue
A	ASN688
A	GLY689
A	THR690
A	HIS692
A	HOH2381
A	HOH2831
A	TYR212
A	ASP534

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1698

Chain	Residue
A	THR129
A	ARG130
A	GLU131
A	SER428
A	HOH2587
A	HOH2832

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1699

Chain	Residue
A	ASP30
A	ALA89
A	ASP94
A	HIS101
A	LEU192
A	HOH2833
A	HOH2834
A	HOH2835

---

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 1700

Chain	Residue
A	SER287
A	PHE288
A	ARG292
A	MET324
A	GLN687
A	THR690
A	THR695
A	HOH2457
A	HOH2836
A	HOH2837
A	HOH2838

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 1701

Chain	Residue
A	ASN441
A	LEU442
A	ILE447
A	HOH2675

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 1702

Chain	Residue
A	THR443
A	LEU444
A	HIS486
A	GLN489

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:21565699

Chain	Residue	Details
A	ASP323

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000269|PubMed:21565699

Chain	Residue	Details
A	GLU352

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:21565699, ECO:0007744|PDB:2YA0

Chain	Residue	Details
A	SER206
A	TYR208
A	ASP537

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:21565699, ECO:0007744|PDB:2YA1

Chain	Residue	Details
A	TYR212
A	PHE288
A	TRP354
A	ASP384
A	ARG387
A	TYR394
A	ASN441
A	LYS514

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:21565699, ECO:0007744|PDB:2YA2

Chain	Residue	Details
A	MET373
A	THR376
A	ASP377
A	ASP427
A	ASP431

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:21565699, ECO:0007744|PDB:2YA1, ECO:0007744|PDB:2YA2

Chain	Residue	Details
A	ASP534

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	SITE: Transition state stabilizer => ECO:0000305|PubMed:21565699

Chain	Residue	Details
A	ASP440

---