2Y9X

Crystal structure of PPO3, a tyrosinase from Agaricus bisporus, in deoxy-form that contains additional unknown lectin-like subunit, with inhibitor tropolone

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
B	0016491	molecular_function	oxidoreductase activity
C	0016491	molecular_function	oxidoreductase activity
D	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU A 400

Chain	Residue
A	HIS61
A	CYS83
A	HIS85
A	HIS94

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU A 401

Chain	Residue
A	HIS259
A	HIS263
A	HIS296
A	0TR410

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 0TR A 410

Chain	Residue
A	HIS263
A	PHE264
A	MET280
A	VAL283
A	ALA286
A	CU401
A	ASN260

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE HO A 402

Chain	Residue
A	ASP336
A	GLN351
A	ASP353
B	ASP312

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU B 400

Chain	Residue
B	HIS61
B	CYS83
B	HIS85
B	HIS94

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU B 401

Chain	Residue
B	HIS259
B	HIS263
B	HIS296
B	0TR410

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE HO B 402

Chain	Residue
A	ASP312
B	ASP336
B	GLN351
B	ASP353

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 0TR B 410

Chain	Residue
B	ASN260
B	HIS263
B	PHE264
B	VAL283
B	ALA286
B	CU401

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU C 400

Chain	Residue
C	HIS61
C	CYS83
C	HIS85
C	HIS94
C	0TR410

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU C 401

Chain	Residue
C	HIS259
C	HIS263
C	HIS296
C	0TR410

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE HO C 402

Chain	Residue
C	ASP336
C	GLN351
C	ASP353
C	HOH2002
D	ASP312

---

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 0TR C 410

Chain	Residue
C	HIS61
C	HIS85
C	HIS259
C	ASN260
C	HIS263
C	VAL283
C	ALA286
C	CU400
C	CU401

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU D 400

Chain	Residue
D	HIS61
D	CYS83
D	HIS85
D	HIS94
D	0TR410

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU D 401

Chain	Residue
D	HIS259
D	HIS263
D	HIS296
D	0TR410

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE HO D 402

Chain	Residue
C	ASP312
D	ASP336
D	GLN351
D	ASP353
D	HOH2003

---

site_id	BC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 0TR D 410

Chain	Residue
D	HIS61
D	HIS85
D	HIS259
D	ASN260
D	HIS263
D	MET280
D	VAL283
D	ALA286
D	PHE292
D	CU400
D	CU401

---

Functional Information from PROSITE/UniProt

site_id	PS00498
Number of Residues	12
Details	TYROSINASE_2 Tyrosinase and hemocyanins CuB-binding region signature. DPiFWmhHcnvD

Chain	Residue	Details
A	ASP289-ASP300

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:21598903

Chain	Residue	Details
A	HIS61
B	HIS259
B	HIS263
B	HIS296
C	HIS61
C	HIS85
C	HIS94
C	HIS259
C	HIS263
C	HIS296
D	HIS61
A	HIS85
D	HIS85
D	HIS94
D	HIS259
D	HIS263
D	HIS296
A	HIS94
A	HIS259
A	HIS263
A	HIS296
B	HIS61
B	HIS85
B	HIS94

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Cleavage => ECO:0000305

Chain	Residue	Details
A	GLY392
B	GLY392
C	GLY392
D	GLY392

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	CROSSLNK: 2'-(S-cysteinyl)-histidine (Cys-His) => ECO:0000269|PubMed:21598903

Chain	Residue	Details
A	CYS83
A	HIS85
B	CYS83
B	HIS85
C	CYS83
C	HIS85
D	CYS83
D	HIS85

---