2Y85
CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS PHOSPHORIBOSYL ISOMERASE WITH BOUND RCDRP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000105 | biological_process | L-histidine biosynthetic process |
| A | 0000162 | biological_process | L-tryptophan biosynthetic process |
| A | 0003949 | molecular_function | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity |
| A | 0004640 | molecular_function | phosphoribosylanthranilate isomerase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0016853 | molecular_function | isomerase activity |
| B | 0000105 | biological_process | L-histidine biosynthetic process |
| B | 0000162 | biological_process | L-tryptophan biosynthetic process |
| B | 0003949 | molecular_function | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity |
| B | 0004640 | molecular_function | phosphoribosylanthranilate isomerase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0016853 | molecular_function | isomerase activity |
| C | 0000105 | biological_process | L-histidine biosynthetic process |
| C | 0000162 | biological_process | L-tryptophan biosynthetic process |
| C | 0003949 | molecular_function | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity |
| C | 0004640 | molecular_function | phosphoribosylanthranilate isomerase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| C | 0016853 | molecular_function | isomerase activity |
| D | 0000105 | biological_process | L-histidine biosynthetic process |
| D | 0000162 | biological_process | L-tryptophan biosynthetic process |
| D | 0003949 | molecular_function | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity |
| D | 0004640 | molecular_function | phosphoribosylanthranilate isomerase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| D | 0016853 | molecular_function | isomerase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 1245 |
| Chain | Residue |
| A | GLY201 |
| A | GLY202 |
| A | VAL203 |
| A | ILE224 |
| A | 1371247 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 1246 |
| Chain | Residue |
| A | GLY104 |
| A | GLY82 |
| A | GLY83 |
| A | ILE84 |
| A | ASN102 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 137 A 1247 |
| Chain | Residue |
| A | ALA9 |
| A | ASP11 |
| A | HIS50 |
| A | VAL52 |
| A | LEU54 |
| A | ALA57 |
| A | SER81 |
| A | ARG143 |
| A | ASP175 |
| A | GLY176 |
| A | SER200 |
| A | GLY201 |
| A | GLY202 |
| A | GLY226 |
| A | LYS227 |
| A | NA1245 |
| A | HOH2033 |
| A | HOH2034 |
| A | HOH2035 |
| A | HOH2036 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 1248 |
| Chain | Residue |
| A | LEU129 |
| A | ASP130 |
| A | ARG143 |
| A | VAL168 |
| A | THR170 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 1249 |
| Chain | Residue |
| A | ILE172 |
| A | THR173 |
| A | ASP175 |
| A | THR177 |
| B | GLN132 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 1245 |
| Chain | Residue |
| B | GLY201 |
| B | GLY202 |
| B | VAL203 |
| B | ILE224 |
| B | 1371247 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CL B 1246 |
| Chain | Residue |
| B | SER81 |
| B | GLY82 |
| B | GLY83 |
| B | ILE84 |
| B | ASN102 |
| B | GLY104 |
| B | HOH2047 |
| site_id | AC8 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE 137 B 1247 |
| Chain | Residue |
| B | ALA9 |
| B | ASP11 |
| B | HIS50 |
| B | VAL52 |
| B | SER81 |
| B | GLY82 |
| B | ARG143 |
| B | ASP175 |
| B | GLY176 |
| B | SER200 |
| B | GLY201 |
| B | GLY202 |
| B | VAL225 |
| B | GLY226 |
| B | LYS227 |
| B | NA1245 |
| B | HOH2047 |
| B | HOH2048 |
| B | HOH2049 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 1248 |
| Chain | Residue |
| B | LEU129 |
| B | ASP130 |
| B | VAL168 |
| B | VAL169 |
| B | THR170 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA C 1245 |
| Chain | Residue |
| C | GLY201 |
| C | GLY202 |
| C | VAL203 |
| C | ILE224 |
| C | 1371247 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL C 1246 |
| Chain | Residue |
| C | SER81 |
| C | GLY82 |
| C | GLY83 |
| C | ILE84 |
| C | ASN102 |
| C | GLY104 |
| site_id | BC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 137 C 1247 |
| Chain | Residue |
| C | GLY201 |
| C | GLY202 |
| C | GLY226 |
| C | LYS227 |
| C | NA1245 |
| C | HOH2049 |
| C | HOH2050 |
| C | HOH2051 |
| C | ALA9 |
| C | ASP11 |
| C | HIS50 |
| C | VAL52 |
| C | LEU54 |
| C | ALA57 |
| C | SER81 |
| C | GLY82 |
| C | ARG143 |
| C | ASP175 |
| C | GLY176 |
| C | SER200 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA C 1248 |
| Chain | Residue |
| C | LEU129 |
| C | ASP130 |
| C | VAL168 |
| C | THR170 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA C 1249 |
| Chain | Residue |
| C | ILE172 |
| C | THR173 |
| C | LYS174 |
| C | ASP175 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA D 1245 |
| Chain | Residue |
| D | GLY201 |
| D | GLY202 |
| D | VAL203 |
| D | ILE224 |
| D | 1371247 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CL D 1246 |
| Chain | Residue |
| D | SER81 |
| D | GLY82 |
| D | GLY83 |
| D | ILE84 |
| D | ASN102 |
| D | GLY104 |
| D | HOH2015 |
| D | HOH2050 |
| site_id | BC8 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE 137 D 1247 |
| Chain | Residue |
| D | ALA9 |
| D | ASP11 |
| D | HIS50 |
| D | VAL52 |
| D | SER81 |
| D | GLY82 |
| D | ARG143 |
| D | ASP175 |
| D | GLY176 |
| D | SER200 |
| D | GLY201 |
| D | GLY202 |
| D | GLY226 |
| D | LYS227 |
| D | NA1245 |
| D | HOH2040 |
| D | HOH2050 |
| D | HOH2051 |
| D | HOH2052 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA D 1248 |
| Chain | Residue |
| D | LEU129 |
| D | ASP130 |
| D | ARG143 |
| D | VAL168 |
| D | THR170 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA D 1249 |
| Chain | Residue |
| D | ILE172 |
| D | THR173 |
| D | LYS174 |
| D | ASP175 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
