Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2Y6R

Structure of the TetX monooxygenase in complex with the substrate 7- chlortetracycline

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004497	molecular_function	monooxygenase activity
A	0005737	cellular_component	cytoplasm
A	0016491	molecular_function	oxidoreductase activity
A	0046677	biological_process	response to antibiotic
A	0071949	molecular_function	FAD binding
B	0000166	molecular_function	nucleotide binding
B	0004497	molecular_function	monooxygenase activity
B	0005737	cellular_component	cytoplasm
B	0016491	molecular_function	oxidoreductase activity
B	0046677	biological_process	response to antibiotic
B	0071949	molecular_function	FAD binding
C	0000166	molecular_function	nucleotide binding
C	0004497	molecular_function	monooxygenase activity
C	0005737	cellular_component	cytoplasm
C	0016491	molecular_function	oxidoreductase activity
C	0046677	biological_process	response to antibiotic
C	0071949	molecular_function	FAD binding
D	0000166	molecular_function	nucleotide binding
D	0004497	molecular_function	monooxygenase activity
D	0005737	cellular_component	cytoplasm
D	0016491	molecular_function	oxidoreductase activity
D	0046677	biological_process	response to antibiotic
D	0071949	molecular_function	FAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE FAD A 1384

Chain	Residue
A	ILE22
A	ARG117
A	ARG137
A	LEU139
A	ALA167
A	ASN168
A	GLY169
A	GLN192
A	GLY310
A	ASP311
A	PRO318
A	GLY23
A	GLY321
A	GLN322
A	GLY323
A	VAL324
A	ASN325
A	CTC1385
A	GLY24
A	GLY25
A	PRO26
A	VAL27
A	TYR45
A	GLU46
A	ARG47

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CTC A 1385

Chain	Residue
A	GLN192
A	ARG213
A	MET215
A	PHE224
A	HIS234
A	GLY236
A	PRO318
A	PHE319
A	ALA320
A	GLY321
A	MET375
A	FAD1384

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1386

Chain	Residue
A	ALA53
A	ARG54
D	ARG54

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1387

Chain	Residue
A	ARG47
A	LYS138

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1388

Chain	Residue
A	ARG137
A	LYS156

site_id	AC6
Number of Residues	25
Details	BINDING SITE FOR RESIDUE FAD B 1384

Chain	Residue
B	ILE22
B	GLY23
B	GLY24
B	GLY25
B	PRO26
B	VAL27
B	TYR45
B	GLU46
B	ARG47
B	ASP48
B	ARG117
B	ARG121
B	ARG137
B	LEU139
B	ALA167
B	ASN168
B	GLY169
B	GLN192
B	GLY310
B	ASP311
B	PRO318
B	GLY321
B	GLY323
B	VAL324
B	CTC1385

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE CTC B 1385

Chain	Residue
B	GLN192
B	ARG213
B	MET215
B	PHE224
B	GLY236
B	PRO318
B	PHE319
B	ALA320
B	GLY321
B	MET375
B	FAD1384

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 1386

Chain	Residue
B	ALA53
B	ARG54
C	ARG54

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 1387

Chain	Residue
B	ARG137
B	LYS156

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 B 1388

Chain	Residue
B	LYS138

site_id	BC2
Number of Residues	26
Details	BINDING SITE FOR RESIDUE FAD C 1384

Chain	Residue
C	ASN168
C	GLY169
C	GLN192
C	GLY310
C	ASP311
C	PRO318
C	GLY321
C	GLN322
C	GLY323
C	VAL324
C	ASN325
C	CTC1385
C	HOH2019
C	GLY23
C	GLY25
C	PRO26
C	VAL27
C	GLY28
C	GLU46
C	ARG47
C	ASP48
C	ARG117
C	ARG121
C	ARG137
C	LYS138
C	LEU139

site_id	BC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE CTC C 1385

Chain	Residue
C	ASP61
C	ASN190
C	GLN192
C	ARG213
C	MET215
C	PHE224
C	HIS234
C	PHE235
C	GLY236
C	PRO318
C	PHE319
C	ALA320
C	GLY321
C	MET375
C	FAD1384

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 C 1386

Chain	Residue
C	LYS138

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 1387

Chain	Residue
C	ARG137
C	LYS156

site_id	BC6
Number of Residues	26
Details	BINDING SITE FOR RESIDUE FAD D 1384

Chain	Residue
D	GLY23
D	GLY25
D	PRO26
D	VAL27
D	TYR45
D	GLU46
D	ARG47
D	ASP48
D	ASP61
D	ARG117
D	ARG121
D	ARG137
D	LYS138
D	LEU139
D	ASN168
D	GLY169
D	GLN192
D	GLY310
D	ASP311
D	PRO318
D	GLY321
D	GLN322
D	GLY323
D	VAL324
D	ASN325
D	CTC1385

site_id	BC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CTC D 1385

Chain	Residue
D	ASP61
D	GLN192
D	ARG213
D	MET215
D	PHE224
D	ALA225
D	HIS234
D	GLY236
D	PRO318
D	FAD1384

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 1386

Chain	Residue
A	ARG54
D	ARG54
D	HOH2017

site_id	BC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 D 1387

Chain	Residue
D	LYS138

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 1388

Chain	Residue
D	ARG137
D	LYS156

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21402075","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21590745","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XYO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Y6Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Y6R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P9U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V3O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4A6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4A99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GUV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00845","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21402075","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00845","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3V3O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00845","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21402075","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21590745","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XYO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Y6Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Y6R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P9U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V3O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4A6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4A99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GUV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21402075","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23999299","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Y6Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Y6R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4A99","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21402075","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23999299","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Y6Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Y6R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V3O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4A6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4A99","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)