Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2Y3Q

1.55A structure of apo bacterioferritin from E. coli

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004322	molecular_function	ferroxidase activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0008199	molecular_function	ferric iron binding
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0020037	molecular_function	heme binding
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0046872	molecular_function	metal ion binding
A	0140315	molecular_function	iron ion sequestering activity
B	0004322	molecular_function	ferroxidase activity
B	0005506	molecular_function	iron ion binding
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0008199	molecular_function	ferric iron binding
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0020037	molecular_function	heme binding
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0046872	molecular_function	metal ion binding
B	0140315	molecular_function	iron ion sequestering activity
C	0004322	molecular_function	ferroxidase activity
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0006826	biological_process	iron ion transport
C	0006879	biological_process	intracellular iron ion homeostasis
C	0008199	molecular_function	ferric iron binding
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0020037	molecular_function	heme binding
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0046872	molecular_function	metal ion binding
C	0140315	molecular_function	iron ion sequestering activity
D	0004322	molecular_function	ferroxidase activity
D	0005506	molecular_function	iron ion binding
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0008199	molecular_function	ferric iron binding
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0020037	molecular_function	heme binding
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0046872	molecular_function	metal ion binding
D	0140315	molecular_function	iron ion sequestering activity
E	0004322	molecular_function	ferroxidase activity
E	0005506	molecular_function	iron ion binding
E	0005515	molecular_function	protein binding
E	0005829	cellular_component	cytosol
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0008199	molecular_function	ferric iron binding
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0020037	molecular_function	heme binding
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0046872	molecular_function	metal ion binding
E	0140315	molecular_function	iron ion sequestering activity
F	0004322	molecular_function	ferroxidase activity
F	0005506	molecular_function	iron ion binding
F	0005515	molecular_function	protein binding
F	0005829	cellular_component	cytosol
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0008199	molecular_function	ferric iron binding
F	0016020	cellular_component	membrane
F	0016491	molecular_function	oxidoreductase activity
F	0020037	molecular_function	heme binding
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0046872	molecular_function	metal ion binding
F	0140315	molecular_function	iron ion sequestering activity
G	0004322	molecular_function	ferroxidase activity
G	0005506	molecular_function	iron ion binding
G	0005515	molecular_function	protein binding
G	0005829	cellular_component	cytosol
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0008199	molecular_function	ferric iron binding
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0020037	molecular_function	heme binding
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0046872	molecular_function	metal ion binding
G	0140315	molecular_function	iron ion sequestering activity
H	0004322	molecular_function	ferroxidase activity
H	0005506	molecular_function	iron ion binding
H	0005515	molecular_function	protein binding
H	0005829	cellular_component	cytosol
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0008199	molecular_function	ferric iron binding
H	0016020	cellular_component	membrane
H	0016491	molecular_function	oxidoreductase activity
H	0020037	molecular_function	heme binding
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0046872	molecular_function	metal ion binding
H	0140315	molecular_function	iron ion sequestering activity
I	0004322	molecular_function	ferroxidase activity
I	0005506	molecular_function	iron ion binding
I	0005515	molecular_function	protein binding
I	0005829	cellular_component	cytosol
I	0006826	biological_process	iron ion transport
I	0006879	biological_process	intracellular iron ion homeostasis
I	0008199	molecular_function	ferric iron binding
I	0016020	cellular_component	membrane
I	0016491	molecular_function	oxidoreductase activity
I	0020037	molecular_function	heme binding
I	0042802	molecular_function	identical protein binding
I	0042803	molecular_function	protein homodimerization activity
I	0046872	molecular_function	metal ion binding
I	0140315	molecular_function	iron ion sequestering activity
J	0004322	molecular_function	ferroxidase activity
J	0005506	molecular_function	iron ion binding
J	0005515	molecular_function	protein binding
J	0005829	cellular_component	cytosol
J	0006826	biological_process	iron ion transport
J	0006879	biological_process	intracellular iron ion homeostasis
J	0008199	molecular_function	ferric iron binding
J	0016020	cellular_component	membrane
J	0016491	molecular_function	oxidoreductase activity
J	0020037	molecular_function	heme binding
J	0042802	molecular_function	identical protein binding
J	0042803	molecular_function	protein homodimerization activity
J	0046872	molecular_function	metal ion binding
J	0140315	molecular_function	iron ion sequestering activity
K	0004322	molecular_function	ferroxidase activity
K	0005506	molecular_function	iron ion binding
K	0005515	molecular_function	protein binding
K	0005829	cellular_component	cytosol
K	0006826	biological_process	iron ion transport
K	0006879	biological_process	intracellular iron ion homeostasis
K	0008199	molecular_function	ferric iron binding
K	0016020	cellular_component	membrane
K	0016491	molecular_function	oxidoreductase activity
K	0020037	molecular_function	heme binding
K	0042802	molecular_function	identical protein binding
K	0042803	molecular_function	protein homodimerization activity
K	0046872	molecular_function	metal ion binding
K	0140315	molecular_function	iron ion sequestering activity
L	0004322	molecular_function	ferroxidase activity
L	0005506	molecular_function	iron ion binding
L	0005515	molecular_function	protein binding
L	0005829	cellular_component	cytosol
L	0006826	biological_process	iron ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0008199	molecular_function	ferric iron binding
L	0016020	cellular_component	membrane
L	0016491	molecular_function	oxidoreductase activity
L	0020037	molecular_function	heme binding
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0046872	molecular_function	metal ion binding
L	0140315	molecular_function	iron ion sequestering activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEM A 200

Chain	Residue
A	LEU19
A	HOH2252
A	HOH2253
A	HOH2254
B	ASN23
B	PHE26
B	TYR45
B	MET52
B	LYS53
B	ALA55
B	ASP56
A	ASN23
B	HEM200
B	HOH2224
A	TYR45
A	ILE49
A	MET52
A	LYS53
A	HOH2249
A	HOH2250
A	HOH2251

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HEM C 200

Chain	Residue
C	ILE22
C	ASN23
C	PHE26
C	TYR45
C	MET52
C	LYS53
C	ALA55
C	ASP56
C	HOH2234
C	HOH2235
C	HOH2236
C	HOH2237
D	ASN23
D	PHE26
D	TYR45
D	MET52
D	LYS53
D	HEM200

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HEM D 200

Chain	Residue
C	ASN23
C	PHE26
C	TYR45
C	ILE49
C	MET52
C	LYS53
C	HEM200
C	HOH2234
C	HOH2236
D	ILE22
D	ASN23
D	PHE26
D	TYR45
D	ILE49
D	MET52
D	LYS53
D	ALA55
D	HOH2241

site_id	AC4
Number of Residues	23
Details	BINDING SITE FOR RESIDUE HEM E 200

Chain	Residue
E	LEU19
E	ILE22
E	ASN23
E	PHE26
E	TYR45
E	ILE49
E	MET52
E	LYS53
E	HOH2244
E	HOH2245
E	HOH2246
E	HOH2247
F	LEU19
F	ASN23
F	PHE26
F	TYR45
F	ILE49
F	MET52
F	LYS53
F	HEM200
F	HOH2235
F	HOH2236
F	HOH2237

site_id	AC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE HEM F 200

Chain	Residue
F	HOH2235
F	HOH2236
F	HOH2237
E	LEU19
E	ASN23
E	TYR45
E	ILE49
E	MET52
E	LEU71
E	HEM200
E	HOH2245
E	HOH2246
E	HOH2247
F	LEU19
F	ILE22
F	ASN23
F	PHE26
F	TYR45
F	MET52
F	LYS53
F	ALA55
F	ASP56

site_id	AC6
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HEM G 200

Chain	Residue
G	ILE22
G	ASN23
G	PHE26
G	TYR45
G	ILE49
G	MET52
G	LYS53
G	ALA55
G	HOH2246
G	HOH2247
H	ASN23
H	TYR45
H	ILE49
H	MET52
H	LEU71
H	HEM200
H	HOH2234
H	HOH2235

site_id	AC7
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM H 200

Chain	Residue
G	ASN23
G	TYR45
G	ILE49
G	MET52
G	LEU71
G	HEM200
G	HOH2246
G	HOH2247
H	ASN23
H	PHE26
H	TYR45
H	ILE49
H	MET52
H	LYS53
H	ALA55
H	ASP56
H	HOH2234
H	HOH2235
H	HOH2236

site_id	AC8
Number of Residues	23
Details	BINDING SITE FOR RESIDUE HEM I 200

Chain	Residue
I	ASN23
I	PHE26
I	TYR45
I	ILE49
I	MET52
I	LYS53
I	ALA55
I	ASP56
I	HOH2244
I	HOH2245
J	LEU19
J	ASN23
J	PHE26
J	TYR45
J	ILE49
J	MET52
J	LYS53
J	HEM200
J	HOH2246
J	HOH2247
J	HOH2248
J	HOH2249
J	HOH2251

site_id	AC9
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEM J 200

Chain	Residue
I	ASN23
I	TYR45
I	ILE49
I	MET52
I	LYS53
I	HEM200
I	HOH2244
J	ASN23
J	PHE26
J	TYR45
J	MET52
J	LYS53
J	ALA55
J	ASP56
J	HOH2246
J	HOH2247
J	HOH2248
J	HOH2249
J	HOH2250
J	HOH2251

site_id	BC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEM K 200

Chain	Residue
K	ASN23
K	PHE26
K	TYR45
K	ILE49
K	MET52
K	HOH2244
K	HOH2245
K	HOH2246
K	HOH2247
K	HOH2248
L	ILE22
L	ASN23
L	PHE26
L	TYR45
L	MET52
L	LYS53
L	ALA55
L	ASP56
L	HEM200
L	HOH2225
L	HOH2226

site_id	BC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM L 200

Chain	Residue
K	ILE22
K	ASN23
K	PHE26
K	TYR45
K	MET52
K	LYS53
K	ALA55
K	HEM200
K	HOH2244
K	HOH2245
K	HOH2246
L	ASN23
L	TYR45
L	ILE49
L	MET52
L	LYS53
L	LEU71
L	HOH2225
L	HOH2226

site_id	BC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SO4 B 1159

Chain	Residue
B	HIS112
B	TYR114
B	HOH2170
B	HOH2225
B	HOH2226
B	HOH2227
D	GLY106
D	TYR107
J	SER110
J	HIS112
J	HOH2198

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1159

Chain	Residue
A	GLY145
A	LEU146
A	GLN147
A	HOH2255
A	HOH2256
J	HOH2234

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 J 1159

Chain	Residue
J	GLY145
J	LEU146
J	GLN147
J	HOH2252
J	HOH2253
K	HOH2231

site_id	BC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SO4 B 1160

Chain	Residue
B	ARG117
B	HOH2183
B	HOH2228
B	HOH2229
B	HOH2230
B	HOH2231
B	HOH2232
D	ARG117
D	HOH2199
F	ARG117
F	HOH2190

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 1161

Chain	Residue
B	GLY145
B	LEU146
B	GLN147
B	HOH2233
B	HOH2234
E	HOH2232

site_id	BC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SO4 C 1158

Chain	Residue
C	ARG117
C	HOH2193
C	HOH2238
C	HOH2239
C	HOH2240
C	HOH2241
C	HOH2242
C	HOH2243
G	ARG117
G	HOH2203
K	ARG117
K	HOH2200

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 1159

Chain	Residue
C	GLY145
C	LEU146
C	GLN147
C	HOH2244
C	HOH2245

site_id	CC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 C 1160

Chain	Residue
A	SER110
A	HIS112
C	HIS112
C	TYR114
C	HOH2246
C	HOH2248
C	HOH2249
K	GLY106
K	HOH2186

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 D 1159

Chain	Residue
D	GLY145
D	LEU146
D	GLN147
D	HOH2242
D	HOH2243
D	HOH2244
D	HOH2245

site_id	CC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SO4 E 1159

Chain	Residue
A	ARG117
A	HOH2196
A	HOH2198
E	ARG117
E	HOH2203
E	HOH2248
E	HOH2249
E	HOH2250
E	HOH2251
E	HOH2252
I	ARG117
I	HOH2202

site_id	CC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 E 1160

Chain	Residue
B	HOH2212
E	GLY145
E	LEU146
E	GLN147
E	HOH2253
E	HOH2254
E	HOH2255

site_id	CC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 F 1159

Chain	Residue
F	GLY145
F	LEU146
F	GLN147
F	HOH2238
F	HOH2239
F	HOH2240
F	HOH2241

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 G 1159

Chain	Residue
G	GLY145
G	LEU146
G	GLN147
G	HOH2248
G	HOH2249

site_id	CC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SO4 H 1159

Chain	Residue
H	ARG117
H	HOH2194
H	HOH2195
H	HOH2237
H	HOH2238
H	HOH2239
H	HOH2240
H	HOH2241
J	ARG117
J	HOH2203
L	ARG117
L	HOH2180

site_id	CC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 H 1160

Chain	Residue
H	GLY145
H	LEU146
H	GLN147
H	HOH2242
H	HOH2243
H	HOH2244
I	HOH2232

site_id	CC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 I 1159

Chain	Residue
I	GLY145
I	LEU146
I	GLN147
I	HOH2233
I	HOH2246
I	HOH2247
I	HOH2248

site_id	DC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 K 1159

Chain	Residue
D	HOH2228
K	GLY145
K	LEU146
K	GLN147
K	HOH2249
K	HOH2250
K	HOH2251

site_id	DC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 L 1159

Chain	Residue
G	HOH2235
L	GLY145
L	LEU146
L	GLN147
L	HOH2227
L	HOH2228
L	HOH2229

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 1160

Chain	Residue
A	ARG57
A	MET119
A	HOH2117
E	ARG125

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT B 1162

Chain	Residue
B	ARG57
B	MET119
B	HOH2236
D	ARG125
D	BTB1161

site_id	DC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT C 1161

Chain	Residue
C	ARG57
C	MET119
C	HOH2250
C	HOH2251
K	ARG125
K	BTB1161

site_id	DC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT D 1160

Chain	Residue
D	ARG57
D	MET119
D	HOH2121
F	ARG125

site_id	DC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT L 1160

Chain	Residue
J	ARG125
L	ARG57
L	MET119
L	HOH2096
L	HOH2230

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT G 1160

Chain	Residue
C	ARG125
G	ARG57
G	MET119
G	HOH2250

site_id	DC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT J 1160

Chain	Residue
H	ARG125
J	ARG57
J	MET119
J	HOH2254

site_id	EC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT K 1160

Chain	Residue
G	ARG125
K	ARG57
K	MET119
K	HOH2252

site_id	EC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT F 1160

Chain	Residue
B	ARG125
F	ARG57
F	MET119
F	HOH2243

site_id	EC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT E 1161

Chain	Residue
E	ARG57
E	MET119
E	HOH2256
I	ARG125

site_id	EC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT I 1160

Chain	Residue
A	ARG125
I	ARG57
I	MET119
I	HOH2249
I	HOH2250

site_id	EC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT H 1161

Chain	Residue
H	ARG57
H	MET119
H	HOH2245
L	ARG125
L	BTB1161

site_id	EC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 I 1161

Chain	Residue
E	HIS112
E	TYR114
G	SER110
G	HIS112
I	GLY106
I	HOH2187
I	HOH2251
I	HOH2252
I	HOH2253
I	HOH2254

site_id	EC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE BTB K 1161

Chain	Residue
C	ARG61
C	PHE64
C	ACT1161
K	ARG125
K	GLU128
K	GLY129
K	ASP132
K	HOH2253
K	HOH2254

site_id	EC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE BTB I 1162

Chain	Residue
E	ARG61
E	PHE64
I	ARG125
I	GLU128
I	GLY129
I	ASP132
I	HOH2204
I	HOH2256
I	HOH2257

site_id	EC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE BTB D 1161

Chain	Residue
B	ARG61
B	PHE64
B	ACT1162
D	ARG125
D	GLU128
D	GLY129
D	ASP132
D	HOH2246
D	HOH2247

site_id	FC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE BTB L 1161

Chain	Residue
H	ARG61
H	PHE64
H	ACT1161
L	ARG125
L	GLU128
L	ASP132
L	HOH2231
L	HOH2233

Functional Information from PROSITE/UniProt

site_id	PS00549
Number of Residues	19
Details	BACTERIOFERRITIN Bacterioferritin signature. MkGdtkVInyLnklLgneL

Chain	Residue	Details
A	MET1-LEU19

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1728
Details	Domain: {"description":"Ferritin-like diiron","evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	96
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17077480","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17077480","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)