2Y04
TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST SALBUTAMOL
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004930 | molecular_function | G protein-coupled receptor activity |
A | 0004935 | molecular_function | adrenergic receptor activity |
A | 0004940 | molecular_function | beta1-adrenergic receptor activity |
A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
A | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
A | 0016020 | cellular_component | membrane |
A | 0045823 | biological_process | positive regulation of heart contraction |
B | 0004930 | molecular_function | G protein-coupled receptor activity |
B | 0004935 | molecular_function | adrenergic receptor activity |
B | 0004940 | molecular_function | beta1-adrenergic receptor activity |
B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
B | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
B | 0016020 | cellular_component | membrane |
B | 0045823 | biological_process | positive regulation of heart contraction |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE Y01 A 401 |
Chain | Residue |
A | GLU130 |
B | 2CV503 |
A | CYS133 |
A | ARG157 |
A | ILE161 |
A | THR164 |
A | ILE214 |
B | ARG205 |
B | ALA206 |
B | ALA210 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE Y01 A 402 |
Chain | Residue |
A | LEU78 |
A | SER82 |
A | CYS85 |
A | LEU123 |
A | ARG155 |
A | LYS159 |
A | TRP166 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE 2CV A 501 |
Chain | Residue |
A | PRO176 |
A | TYR207 |
B | THR164 |
B | Y01401 |
B | 2CV505 |
site_id | AC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE 2CV A 502 |
Chain | Residue |
A | LEU289 |
A | GLY293 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE 2CV A 503 |
Chain | Residue |
A | ARG205 |
A | VAL314 |
A | PHE315 |
B | LEU152 |
B | ARG157 |
B | Y01401 |
site_id | AC6 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE 2CV A 504 |
Chain | Residue |
A | VAL326 |
site_id | AC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE 2CV A 505 |
Chain | Residue |
A | CYS163 |
B | 2CV501 |
site_id | AC8 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE 68H A 601 |
Chain | Residue |
A | ASP121 |
A | SER211 |
A | SER215 |
A | PHE306 |
A | PHE307 |
A | ASN310 |
A | ASN329 |
A | TYR333 |
site_id | AC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NA A 701 |
Chain | Residue |
A | CYS192 |
A | ASP195 |
A | CYS198 |
site_id | BC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE Y01 B 401 |
Chain | Residue |
A | ALA206 |
A | ALA210 |
A | 2CV501 |
A | 2CV503 |
B | GLU130 |
B | CYS133 |
B | ARG157 |
B | VAL160 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE Y01 B 402 |
Chain | Residue |
B | LEU78 |
B | ARG155 |
B | LYS159 |
B | TRP166 |
site_id | BC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE 2CV B 501 |
Chain | Residue |
A | VAL160 |
A | 2CV505 |
B | TRP181 |
B | ARG183 |
B | ASP184 |
B | GLU185 |
B | ASN204 |
site_id | BC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE 2CV B 502 |
Chain | Residue |
B | VAL230 |
B | TYR231 |
B | HIS286 |
B | LEU289 |
B | GLY293 |
site_id | BC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE 2CV B 503 |
Chain | Residue |
A | ARG157 |
A | Y01401 |
B | ARG205 |
B | PHE315 |
site_id | BC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE 2CV B 504 |
Chain | Residue |
B | LEU47 |
B | MET48 |
site_id | BC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE 2CV B 505 |
Chain | Residue |
A | GLU185 |
A | 2CV501 |
B | VAL160 |
B | CYS163 |
B | ALA170 |
site_id | BC8 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE 68H B 601 |
Chain | Residue |
B | TRP117 |
B | ASP121 |
B | VAL122 |
B | SER211 |
B | SER215 |
B | PHE306 |
B | PHE307 |
B | ASN329 |
B | TYR333 |
Functional Information from PROSITE/UniProt
site_id | PS00237 |
Number of Residues | 17 |
Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIeTLCVIAIDRYLaI |
Chain | Residue | Details |
A | ALA127-ILE143 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 56 |
Details | TRANSMEM: Helical; Name=1 |
Chain | Residue | Details |
A | GLN39-GLY67 | |
B | GLN39-GLY67 |
site_id | SWS_FT_FI2 |
Number of Residues | 156 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:18594507 |
Chain | Residue | Details |
A | SER68-THR76 | |
A | ASP138-ARG155 | |
A | ARG232-ASN313 | |
B | SER68-THR76 | |
B | ASP138-ARG155 | |
B | ARG232-ASN313 |
site_id | SWS_FT_FI3 |
Number of Residues | 52 |
Details | TRANSMEM: Helical; Name=2 |
Chain | Residue | Details |
A | ASN77-VAL103 | |
B | ASN77-VAL103 |
site_id | SWS_FT_FI4 |
Number of Residues | 80 |
Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:18594507 |
Chain | Residue | Details |
A | ARG104-GLU115 | |
A | HIS180-ARG205 | |
A | CYS344-ASP348 | |
B | ARG104-GLU115 | |
B | HIS180-ARG205 | |
B | CYS344-ASP348 |
site_id | SWS_FT_FI5 |
Number of Residues | 42 |
Details | TRANSMEM: Helical; Name=3 |
Chain | Residue | Details |
A | LEU116-ILE137 | |
B | LEU116-ILE137 |
site_id | SWS_FT_FI6 |
Number of Residues | 46 |
Details | TRANSMEM: Helical; Name=4 |
Chain | Residue | Details |
A | ALA156-MET179 | |
B | ALA156-MET179 |
site_id | SWS_FT_FI7 |
Number of Residues | 50 |
Details | TRANSMEM: Helical; Name=5 |
Chain | Residue | Details |
A | ALA206-TYR231 | |
B | ALA206-TYR231 |
site_id | SWS_FT_FI8 |
Number of Residues | 58 |
Details | TRANSMEM: Helical; Name=6 |
Chain | Residue | Details |
A | VAL314-TYR343 | |
B | VAL314-TYR343 |
site_id | SWS_FT_FI9 |
Number of Residues | 44 |
Details | TRANSMEM: Helical; Name=7 |
Chain | Residue | Details |
A | PHE349-HIS371 | |
B | PHE349-HIS371 |
site_id | SWS_FT_FI10 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 |
Chain | Residue | Details |
A | ASP121 | |
A | SER211 | |
A | LEU357 | |
B | ASP121 | |
B | SER211 | |
B | LEU357 |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
Chain | Residue | Details |