2XZ0
The Structure of the 2:1 (Partially Occupied) Complex Between Stearoyl Acyl Carrier Protein Desaturase from Ricinus Communis (Castor Bean) and Acyl Carrier Protein.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004768 | molecular_function | stearoyl-CoA 9-desaturase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0006952 | biological_process | defense response |
| A | 0009507 | cellular_component | chloroplast |
| A | 0009570 | cellular_component | chloroplast stroma |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0045300 | molecular_function | acyl-[acyl-carrier-protein] desaturase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0102786 | molecular_function | stearoyl-[acp] desaturase activity |
| B | 0004768 | molecular_function | stearoyl-CoA 9-desaturase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0006952 | biological_process | defense response |
| B | 0009507 | cellular_component | chloroplast |
| B | 0009570 | cellular_component | chloroplast stroma |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0045300 | molecular_function | acyl-[acyl-carrier-protein] desaturase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0102786 | molecular_function | stearoyl-[acp] desaturase activity |
| C | 0004768 | molecular_function | stearoyl-CoA 9-desaturase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0006631 | biological_process | fatty acid metabolic process |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0006952 | biological_process | defense response |
| C | 0009507 | cellular_component | chloroplast |
| C | 0009570 | cellular_component | chloroplast stroma |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0045300 | molecular_function | acyl-[acyl-carrier-protein] desaturase activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0102786 | molecular_function | stearoyl-[acp] desaturase activity |
| D | 0000036 | molecular_function | acyl carrier activity |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0031177 | molecular_function | phosphopantetheine binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FE A 1364 |
| Chain | Residue |
| A | GLU105 |
| A | GLU143 |
| A | HIS146 |
| A | GLU229 |
| A | FE1365 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FE A 1365 |
| Chain | Residue |
| A | HOH2009 |
| A | GLU143 |
| A | GLU196 |
| A | GLU229 |
| A | FE1364 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ZN A 1366 |
| Chain | Residue |
| A | GLU106 |
| B | ZN1366 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FE B 1364 |
| Chain | Residue |
| B | GLU105 |
| B | GLU143 |
| B | HIS146 |
| B | GLU229 |
| B | FE1365 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FE B 1365 |
| Chain | Residue |
| B | TRP139 |
| B | GLU143 |
| B | GLU196 |
| B | GLU229 |
| B | HIS232 |
| B | FE1364 |
| B | HOH2001 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1366 |
| Chain | Residue |
| A | ZN1366 |
| B | GLU106 |
| B | ASN144 |
| B | ASP148 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 1367 |
| Chain | Residue |
| B | PRO248 |
| B | GLY315 |
| B | SER317 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FE C 1364 |
| Chain | Residue |
| C | GLU105 |
| C | GLU143 |
| C | HIS146 |
| C | GLU229 |
| C | FE1365 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FE C 1365 |
| Chain | Residue |
| C | GLU143 |
| C | GLU196 |
| C | GLU229 |
| C | FE1364 |
| C | HOH2003 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ZN C 1366 |
| Chain | Residue |
| C | GLU106 |
| C | ASP148 |
Functional Information from PROSITE/UniProt
| site_id | PS00012 |
| Number of Residues | 16 |
| Details | PHOSPHOPANTETHEINE Phosphopantetheine attachment site. KLGADSLDTVEIVMNL |
| Chain | Residue | Details |
| D | LYS33-LEU48 |
| site_id | PS00574 |
| Number of Residues | 20 |
| Details | FATTY_ACID_DESATUR_2 Fatty acid desaturases family 2 signature. SAvaqRLgvytakDYadILE |
| Chain | Residue | Details |
| A | SER283-GLU302 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: O-(pantetheine 4'-phosphoryl)serine => ECO:0000255|PROSITE-ProRule:PRU00258, ECO:0000269|PubMed:16618110 |
| Chain | Residue | Details |
| D | SEP38 | |
| A | GLU196 | |
| A | GLU229 | |
| A | HIS232 | |
| B | GLU105 | |
| B | GLU143 | |
| B | HIS146 | |
| B | GLU196 | |
| B | GLU229 | |
| B | HIS232 | |
| C | GLU105 | |
| C | GLU143 | |
| C | HIS146 | |
| C | GLU196 | |
| C | GLU229 | |
| C | HIS232 | |
| A | GLU143 | |
| A | HIS146 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 9 |
| Details | M-CSA 136 |
| Chain | Residue | Details |
| A | TRP62 | hydrogen bond donor, single electron acceptor, single electron donor, single electron relay |
| A | GLU105 | metal ligand |
| A | GLU143 | metal ligand |
| A | HIS146 | hydrogen bond donor, metal ligand, single electron acceptor, single electron donor, single electron relay |
| A | GLU196 | metal ligand |
| A | THR199 | electrostatic stabiliser, hydrogen bond donor |
| A | ASP228 | hydrogen bond acceptor, single electron acceptor, single electron donor, single electron relay |
| A | GLU229 | metal ligand |
| A | HIS232 | metal ligand |
| site_id | MCSA2 |
| Number of Residues | 9 |
| Details | M-CSA 136 |
| Chain | Residue | Details |
| B | TRP62 | hydrogen bond donor, single electron acceptor, single electron donor, single electron relay |
| B | GLU105 | metal ligand |
| B | GLU143 | metal ligand |
| B | HIS146 | hydrogen bond donor, metal ligand, single electron acceptor, single electron donor, single electron relay |
| B | GLU196 | metal ligand |
| B | THR199 | electrostatic stabiliser, hydrogen bond donor |
| B | ASP228 | hydrogen bond acceptor, single electron acceptor, single electron donor, single electron relay |
| B | GLU229 | metal ligand |
| B | HIS232 | metal ligand |
| site_id | MCSA3 |
| Number of Residues | 9 |
| Details | M-CSA 136 |
| Chain | Residue | Details |
| C | TRP62 | hydrogen bond donor, single electron acceptor, single electron donor, single electron relay |
| C | GLU105 | metal ligand |
| C | GLU143 | metal ligand |
| C | HIS146 | hydrogen bond donor, metal ligand, single electron acceptor, single electron donor, single electron relay |
| C | GLU196 | metal ligand |
| C | THR199 | electrostatic stabiliser, hydrogen bond donor |
| C | ASP228 | hydrogen bond acceptor, single electron acceptor, single electron donor, single electron relay |
| C | GLU229 | metal ligand |
| C | HIS232 | metal ligand |
