Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2XYS

Crystal structure of Aplysia californica AChBP in complex with strychnine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005231	molecular_function	excitatory extracellular ligand-gated monoatomic ion channel activity
A	0005515	molecular_function	protein binding
A	0006811	biological_process	monoatomic ion transport
A	0007165	biological_process	signal transduction
A	0007268	biological_process	chemical synaptic transmission
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042391	biological_process	regulation of membrane potential
A	0042802	molecular_function	identical protein binding
A	0043005	cellular_component	neuron projection
A	0045202	cellular_component	synapse
A	0046872	molecular_function	metal ion binding
A	0050877	biological_process	nervous system process
A	0060078	biological_process	regulation of postsynaptic membrane potential
A	0060079	biological_process	excitatory postsynaptic potential
A	0098794	cellular_component	postsynapse
A	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005231	molecular_function	excitatory extracellular ligand-gated monoatomic ion channel activity
B	0005515	molecular_function	protein binding
B	0006811	biological_process	monoatomic ion transport
B	0007165	biological_process	signal transduction
B	0007268	biological_process	chemical synaptic transmission
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042391	biological_process	regulation of membrane potential
B	0042802	molecular_function	identical protein binding
B	0043005	cellular_component	neuron projection
B	0045202	cellular_component	synapse
B	0046872	molecular_function	metal ion binding
B	0050877	biological_process	nervous system process
B	0060078	biological_process	regulation of postsynaptic membrane potential
B	0060079	biological_process	excitatory postsynaptic potential
B	0098794	cellular_component	postsynapse
B	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005231	molecular_function	excitatory extracellular ligand-gated monoatomic ion channel activity
C	0005515	molecular_function	protein binding
C	0006811	biological_process	monoatomic ion transport
C	0007165	biological_process	signal transduction
C	0007268	biological_process	chemical synaptic transmission
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042391	biological_process	regulation of membrane potential
C	0042802	molecular_function	identical protein binding
C	0043005	cellular_component	neuron projection
C	0045202	cellular_component	synapse
C	0046872	molecular_function	metal ion binding
C	0050877	biological_process	nervous system process
C	0060078	biological_process	regulation of postsynaptic membrane potential
C	0060079	biological_process	excitatory postsynaptic potential
C	0098794	cellular_component	postsynapse
C	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005231	molecular_function	excitatory extracellular ligand-gated monoatomic ion channel activity
D	0005515	molecular_function	protein binding
D	0006811	biological_process	monoatomic ion transport
D	0007165	biological_process	signal transduction
D	0007268	biological_process	chemical synaptic transmission
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0042391	biological_process	regulation of membrane potential
D	0042802	molecular_function	identical protein binding
D	0043005	cellular_component	neuron projection
D	0045202	cellular_component	synapse
D	0046872	molecular_function	metal ion binding
D	0050877	biological_process	nervous system process
D	0060078	biological_process	regulation of postsynaptic membrane potential
D	0060079	biological_process	excitatory postsynaptic potential
D	0098794	cellular_component	postsynapse
D	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005231	molecular_function	excitatory extracellular ligand-gated monoatomic ion channel activity
E	0005515	molecular_function	protein binding
E	0006811	biological_process	monoatomic ion transport
E	0007165	biological_process	signal transduction
E	0007268	biological_process	chemical synaptic transmission
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0042391	biological_process	regulation of membrane potential
E	0042802	molecular_function	identical protein binding
E	0043005	cellular_component	neuron projection
E	0045202	cellular_component	synapse
E	0046872	molecular_function	metal ion binding
E	0050877	biological_process	nervous system process
E	0060078	biological_process	regulation of postsynaptic membrane potential
E	0060079	biological_process	excitatory postsynaptic potential
E	0098794	cellular_component	postsynapse
E	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SY9 A 1206

Chain	Residue
A	TYR91
A	TRP145
A	CYS188
A	TYR193
A	HOH2225
B	TYR53
B	GLN55
B	ILE116
B	SER165

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SY9 B 1206

Chain	Residue
B	TYR91
B	SER144
B	TRP145
B	TYR186
B	CYS188
B	CYS189
B	TYR193
B	HOH2206
C	TYR53

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SY9 C 1206

Chain	Residue
C	TYR91
C	SER144
C	TRP145
C	CYS188
C	TYR193
C	HOH2242
D	TYR53
D	ILE116
D	SER165

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SY9 D 1206

Chain	Residue
D	TYR91
D	SER144
D	TRP145
D	TYR186
D	CYS188
D	TYR193
D	HOH2196
E	TYR53
E	ILE116
E	HOH2189

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SY9 E 1206

Chain	Residue
A	TYR53
E	TYR91
E	SER144
E	TRP145
E	TYR186
E	TYR193
E	SY91207
E	HOH2229

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SY9 E 1207

Chain	Residue
A	THR34
A	GLN55
A	ARG57
A	MET114
A	ILE116
A	ASP162
E	CYS188
E	SY91206

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)