2XWM
Crystal structure of IspD from Mycobacterium smegmatis in complex with CMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| A | 0050518 | molecular_function | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity |
| A | 0070567 | molecular_function | cytidylyltransferase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| B | 0050518 | molecular_function | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity |
| B | 0070567 | molecular_function | cytidylyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE C5P A 301 |
| Chain | Residue |
| A | PRO8 |
| A | SER82 |
| A | ASP100 |
| A | ALA101 |
| A | ALA102 |
| A | LYS204 |
| A | HOH2154 |
| A | HOH2156 |
| A | HOH2157 |
| A | HOH2158 |
| A | HOH2160 |
| A | ALA9 |
| A | ALA10 |
| A | GLY11 |
| A | LYS22 |
| A | GLY76 |
| A | VAL77 |
| A | ASP78 |
| A | ARG79 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE C5P B 301 |
| Chain | Residue |
| B | PRO8 |
| B | ALA9 |
| B | ALA10 |
| B | GLY11 |
| B | SER12 |
| B | GLY13 |
| B | LYS22 |
| B | GLY76 |
| B | VAL77 |
| B | ASP78 |
| B | ARG79 |
| B | SER82 |
| B | ASP100 |
| B | HOH2005 |
| B | HOH2038 |
| B | HOH2045 |
| B | HOH2113 |
| B | HOH2114 |
Functional Information from PROSITE/UniProt
| site_id | PS01295 |
| Number of Residues | 8 |
| Details | ISPD 4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature. VLVHDAAR |
| Chain | Residue | Details |
| A | VAL96-ARG103 |
