2XWL
Crystal structure of IspD from Mycobacterium smegmatis in complex with CTP and Mg
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| A | 0050518 | molecular_function | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity |
| A | 0070567 | molecular_function | cytidylyltransferase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| B | 0050518 | molecular_function | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity |
| B | 0070567 | molecular_function | cytidylyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 300 |
| Chain | Residue |
| A | CTP301 |
| A | HOH2259 |
| A | HOH2260 |
| A | HOH2264 |
| site_id | AC2 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE CTP A 301 |
| Chain | Residue |
| A | GLY13 |
| A | GLU14 |
| A | ARG15 |
| A | LYS22 |
| A | GLY76 |
| A | VAL77 |
| A | ASP78 |
| A | ARG79 |
| A | SER82 |
| A | ASP100 |
| A | ALA101 |
| A | ALA102 |
| A | LYS204 |
| A | MG300 |
| A | HOH2044 |
| A | HOH2122 |
| A | HOH2259 |
| A | HOH2260 |
| A | HOH2261 |
| A | HOH2262 |
| A | HOH2263 |
| A | HOH2264 |
| A | HOH2265 |
| A | HOH2266 |
| A | PRO8 |
| A | ALA9 |
| A | ALA10 |
| A | GLY11 |
| A | SER12 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 300 |
| Chain | Residue |
| B | CTP301 |
| B | HOH2198 |
| B | HOH2201 |
| B | HOH2203 |
| site_id | AC4 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE CTP B 301 |
| Chain | Residue |
| B | PRO8 |
| B | ALA9 |
| B | ALA10 |
| B | GLY11 |
| B | SER12 |
| B | GLY13 |
| B | GLU14 |
| B | ARG15 |
| B | LYS22 |
| B | GLY76 |
| B | VAL77 |
| B | ASP78 |
| B | ARG79 |
| B | SER82 |
| B | ASP100 |
| B | ALA101 |
| B | ALA102 |
| B | LYS204 |
| B | MG300 |
| B | HOH2195 |
| B | HOH2197 |
| B | HOH2198 |
| B | HOH2199 |
| B | HOH2200 |
| B | HOH2201 |
| B | HOH2202 |
| B | HOH2203 |
Functional Information from PROSITE/UniProt
| site_id | PS01295 |
| Number of Residues | 8 |
| Details | ISPD 4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature. VLVHDAAR |
| Chain | Residue | Details |
| A | VAL96-ARG103 |
