2XWA

Crystal Structure of Complement Factor D Mutant R202A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006508	biological_process	proteolysis
A	0006956	biological_process	complement activation
A	0006957	biological_process	complement activation, alternative pathway
A	0008236	molecular_function	serine-type peptidase activity
A	0009617	biological_process	response to bacterium
A	0031093	cellular_component	platelet alpha granule lumen
A	0034774	cellular_component	secretory granule lumen
A	0070062	cellular_component	extracellular exosome
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006508	biological_process	proteolysis
B	0006956	biological_process	complement activation
B	0006957	biological_process	complement activation, alternative pathway
B	0008236	molecular_function	serine-type peptidase activity
B	0009617	biological_process	response to bacterium
B	0031093	cellular_component	platelet alpha granule lumen
B	0034774	cellular_component	secretory granule lumen
B	0070062	cellular_component	extracellular exosome
B	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1230

Chain	Residue
A	VAL117
A	VAL148
A	LEU149
A	ARG151
A	MET169
A	CYS170

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 1230

Chain	Residue
B	VAL148
B	LEU149
B	MET169
B	CYS170
B	ASP116
B	VAL117
B	PRO119

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site_id	CAT
Number of Residues	3
Details	CATALYTIC SITE SHOWS FLIPPED HIS 41 DUE TO SELF-INHIBITORY LOOP

Chain	Residue
A	HIS41
A	ASP89
A	SER199

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Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC

Chain	Residue	Details
A	LEU37-CYS42

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPLV

Chain	Residue	Details
A	ASP177-VAL188

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
A	HIS41
A	ASP89
A	SER183
B	HIS41
B	ASP89
B	SER183

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