2XRC
Human complement factor I
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0006956 | biological_process | complement activation |
| A | 0006958 | biological_process | complement activation, classical pathway |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0045087 | biological_process | innate immune response |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006508 | biological_process | proteolysis |
| B | 0006956 | biological_process | complement activation |
| B | 0006958 | biological_process | complement activation, classical pathway |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0016020 | cellular_component | membrane |
| B | 0045087 | biological_process | innate immune response |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070062 | cellular_component | extracellular exosome |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | extracellular space |
| C | 0006508 | biological_process | proteolysis |
| C | 0006956 | biological_process | complement activation |
| C | 0006958 | biological_process | complement activation, classical pathway |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0016020 | cellular_component | membrane |
| C | 0045087 | biological_process | innate immune response |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070062 | cellular_component | extracellular exosome |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005615 | cellular_component | extracellular space |
| D | 0006508 | biological_process | proteolysis |
| D | 0006956 | biological_process | complement activation |
| D | 0006958 | biological_process | complement activation, classical pathway |
| D | 0008236 | molecular_function | serine-type peptidase activity |
| D | 0016020 | cellular_component | membrane |
| D | 0045087 | biological_process | innate immune response |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070062 | cellular_component | extracellular exosome |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| A | LEU358-CYS363 |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAckGDSGGPLV |
| Chain | Residue | Details |
| A | ASP501-VAL512 |
| site_id | PS01209 |
| Number of Residues | 23 |
| Details | LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIpsqyq.CNgevDCitg.EDEvg...C |
| Chain | Residue | Details |
| A | CYS253-CYS275 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | ACT_SITE: Charge relay system => ECO:0000250|UniProtKB:P00750 |
| Chain | Residue | Details |
| A | HIS362 | |
| D | HIS362 | |
| D | ASP411 | |
| D | SER507 | |
| A | ASP411 | |
| A | SER507 | |
| B | HIS362 | |
| B | ASP411 | |
| B | SER507 | |
| C | HIS362 | |
| C | ASP411 | |
| C | SER507 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 48 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21768352, ECO:0007744|PDB:2XRC |
| Chain | Residue | Details |
| A | LYS221 | |
| A | ASP265 | |
| A | ASP271 | |
| A | GLU272 | |
| B | LYS221 | |
| B | ASP224 | |
| B | ILE226 | |
| B | ASP228 | |
| B | ASP234 | |
| B | GLU235 | |
| B | TYR258 | |
| A | ASP224 | |
| B | ASN261 | |
| B | GLU263 | |
| B | ASP265 | |
| B | ASP271 | |
| B | GLU272 | |
| C | LYS221 | |
| C | ASP224 | |
| C | ILE226 | |
| C | ASP228 | |
| C | ASP234 | |
| A | ILE226 | |
| C | GLU235 | |
| C | TYR258 | |
| C | ASN261 | |
| C | GLU263 | |
| C | ASP265 | |
| C | ASP271 | |
| C | GLU272 | |
| D | LYS221 | |
| D | ASP224 | |
| D | ILE226 | |
| A | ASP228 | |
| D | ASP228 | |
| D | ASP234 | |
| D | GLU235 | |
| D | TYR258 | |
| D | ASN261 | |
| D | GLU263 | |
| D | ASP265 | |
| D | ASP271 | |
| D | GLU272 | |
| A | ASP234 | |
| A | GLU235 | |
| A | TYR258 | |
| A | ASN261 | |
| A | GLU263 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:21768352, ECO:0007744|PDB:2XRC |
| Chain | Residue | Details |
| A | ASN52 | |
| D | ASN52 | |
| D | ASN159 | |
| D | ASN518 | |
| A | ASN159 | |
| A | ASN518 | |
| B | ASN52 | |
| B | ASN159 | |
| B | ASN518 | |
| C | ASN52 | |
| C | ASN159 | |
| C | ASN518 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:21768352, ECO:0007744|PDB:2XRC |
| Chain | Residue | Details |
| A | ASN85 | |
| B | ASN85 | |
| C | ASN85 | |
| D | ASN85 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:21768352, ECO:0007744|PDB:2XRC |
| Chain | Residue | Details |
| A | ASN446 | |
| B | ASN446 | |
| C | ASN446 | |
| D | ASN446 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21768352, ECO:0007744|PDB:2XRC |
| Chain | Residue | Details |
| A | ASN476 | |
| B | ASN476 | |
| C | ASN476 | |
| D | ASN476 |
