2XQ4

Pentameric ligand gated ion channel GLIC in complex with tetramethylarsonium (TMAs)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	990
Details	TOPO_DOM: Periplasmic => ECO:0000255

Chain	Residue	Details
A	GLN1-GLN192
E	ASN244-MET251
A	ASN244-MET251
B	GLN1-GLN192
B	ASN244-MET251
C	GLN1-GLN192
C	ASN244-MET251
D	GLN1-GLN192
D	ASN244-MET251
E	GLN1-GLN192

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site_id	SWS_FT_FI2
Number of Residues	530
Details	TRANSMEM: Helical

Chain	Residue	Details
A	TYR193-PHE215
C	SER219-THR243
C	THR252-VAL280
C	PRO284-PHE316
D	TYR193-PHE215
D	SER219-THR243
D	THR252-VAL280
D	PRO284-PHE316
E	TYR193-PHE215
E	SER219-THR243
E	THR252-VAL280
A	SER219-THR243
E	PRO284-PHE316
A	THR252-VAL280
A	PRO284-PHE316
B	TYR193-PHE215
B	SER219-THR243
B	THR252-VAL280
B	PRO284-PHE316
C	TYR193-PHE215

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site_id	SWS_FT_FI3
Number of Residues	20
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	TRP216-THR218
E	GLU281-GLN283
A	GLU281-GLN283
B	TRP216-THR218
B	GLU281-GLN283
C	TRP216-THR218
C	GLU281-GLN283
D	TRP216-THR218
D	GLU281-GLN283
E	TRP216-THR218

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