Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2XQ1

Crystal structure of peroxisomal catalase from the yeast Hansenula polymorpha

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000302	biological_process	response to reactive oxygen species
A	0004096	molecular_function	catalase activity
A	0004601	molecular_function	peroxidase activity
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005777	cellular_component	peroxisome
A	0005782	cellular_component	peroxisomal matrix
A	0006979	biological_process	response to oxidative stress
A	0016491	molecular_function	oxidoreductase activity
A	0020037	molecular_function	heme binding
A	0042542	biological_process	response to hydrogen peroxide
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0046872	molecular_function	metal ion binding
A	0098869	biological_process	cellular oxidant detoxification
B	0000302	biological_process	response to reactive oxygen species
B	0004096	molecular_function	catalase activity
B	0004601	molecular_function	peroxidase activity
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005777	cellular_component	peroxisome
B	0005782	cellular_component	peroxisomal matrix
B	0006979	biological_process	response to oxidative stress
B	0016491	molecular_function	oxidoreductase activity
B	0020037	molecular_function	heme binding
B	0042542	biological_process	response to hydrogen peroxide
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0046872	molecular_function	metal ion binding
B	0098869	biological_process	cellular oxidant detoxification
C	0000302	biological_process	response to reactive oxygen species
C	0004096	molecular_function	catalase activity
C	0004601	molecular_function	peroxidase activity
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005777	cellular_component	peroxisome
C	0005782	cellular_component	peroxisomal matrix
C	0006979	biological_process	response to oxidative stress
C	0016491	molecular_function	oxidoreductase activity
C	0020037	molecular_function	heme binding
C	0042542	biological_process	response to hydrogen peroxide
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0046872	molecular_function	metal ion binding
C	0098869	biological_process	cellular oxidant detoxification
D	0000302	biological_process	response to reactive oxygen species
D	0004096	molecular_function	catalase activity
D	0004601	molecular_function	peroxidase activity
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005777	cellular_component	peroxisome
D	0005782	cellular_component	peroxisomal matrix
D	0006979	biological_process	response to oxidative stress
D	0016491	molecular_function	oxidoreductase activity
D	0020037	molecular_function	heme binding
D	0042542	biological_process	response to hydrogen peroxide
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0046872	molecular_function	metal ion binding
D	0098869	biological_process	cellular oxidant detoxification
E	0000302	biological_process	response to reactive oxygen species
E	0004096	molecular_function	catalase activity
E	0004601	molecular_function	peroxidase activity
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005777	cellular_component	peroxisome
E	0005782	cellular_component	peroxisomal matrix
E	0006979	biological_process	response to oxidative stress
E	0016491	molecular_function	oxidoreductase activity
E	0020037	molecular_function	heme binding
E	0042542	biological_process	response to hydrogen peroxide
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0046872	molecular_function	metal ion binding
E	0098869	biological_process	cellular oxidant detoxification
F	0000302	biological_process	response to reactive oxygen species
F	0004096	molecular_function	catalase activity
F	0004601	molecular_function	peroxidase activity
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005777	cellular_component	peroxisome
F	0005782	cellular_component	peroxisomal matrix
F	0006979	biological_process	response to oxidative stress
F	0016491	molecular_function	oxidoreductase activity
F	0020037	molecular_function	heme binding
F	0042542	biological_process	response to hydrogen peroxide
F	0042744	biological_process	hydrogen peroxide catabolic process
F	0046872	molecular_function	metal ion binding
F	0098869	biological_process	cellular oxidant detoxification
G	0000302	biological_process	response to reactive oxygen species
G	0004096	molecular_function	catalase activity
G	0004601	molecular_function	peroxidase activity
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005777	cellular_component	peroxisome
G	0005782	cellular_component	peroxisomal matrix
G	0006979	biological_process	response to oxidative stress
G	0016491	molecular_function	oxidoreductase activity
G	0020037	molecular_function	heme binding
G	0042542	biological_process	response to hydrogen peroxide
G	0042744	biological_process	hydrogen peroxide catabolic process
G	0046872	molecular_function	metal ion binding
G	0098869	biological_process	cellular oxidant detoxification
H	0000302	biological_process	response to reactive oxygen species
H	0004096	molecular_function	catalase activity
H	0004601	molecular_function	peroxidase activity
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005777	cellular_component	peroxisome
H	0005782	cellular_component	peroxisomal matrix
H	0006979	biological_process	response to oxidative stress
H	0016491	molecular_function	oxidoreductase activity
H	0020037	molecular_function	heme binding
H	0042542	biological_process	response to hydrogen peroxide
H	0042744	biological_process	hydrogen peroxide catabolic process
H	0046872	molecular_function	metal ion binding
H	0098869	biological_process	cellular oxidant detoxification
I	0000302	biological_process	response to reactive oxygen species
I	0004096	molecular_function	catalase activity
I	0004601	molecular_function	peroxidase activity
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005777	cellular_component	peroxisome
I	0005782	cellular_component	peroxisomal matrix
I	0006979	biological_process	response to oxidative stress
I	0016491	molecular_function	oxidoreductase activity
I	0020037	molecular_function	heme binding
I	0042542	biological_process	response to hydrogen peroxide
I	0042744	biological_process	hydrogen peroxide catabolic process
I	0046872	molecular_function	metal ion binding
I	0098869	biological_process	cellular oxidant detoxification
J	0000302	biological_process	response to reactive oxygen species
J	0004096	molecular_function	catalase activity
J	0004601	molecular_function	peroxidase activity
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005777	cellular_component	peroxisome
J	0005782	cellular_component	peroxisomal matrix
J	0006979	biological_process	response to oxidative stress
J	0016491	molecular_function	oxidoreductase activity
J	0020037	molecular_function	heme binding
J	0042542	biological_process	response to hydrogen peroxide
J	0042744	biological_process	hydrogen peroxide catabolic process
J	0046872	molecular_function	metal ion binding
J	0098869	biological_process	cellular oxidant detoxification
K	0000302	biological_process	response to reactive oxygen species
K	0004096	molecular_function	catalase activity
K	0004601	molecular_function	peroxidase activity
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005777	cellular_component	peroxisome
K	0005782	cellular_component	peroxisomal matrix
K	0006979	biological_process	response to oxidative stress
K	0016491	molecular_function	oxidoreductase activity
K	0020037	molecular_function	heme binding
K	0042542	biological_process	response to hydrogen peroxide
K	0042744	biological_process	hydrogen peroxide catabolic process
K	0046872	molecular_function	metal ion binding
K	0098869	biological_process	cellular oxidant detoxification
L	0000302	biological_process	response to reactive oxygen species
L	0004096	molecular_function	catalase activity
L	0004601	molecular_function	peroxidase activity
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005777	cellular_component	peroxisome
L	0005782	cellular_component	peroxisomal matrix
L	0006979	biological_process	response to oxidative stress
L	0016491	molecular_function	oxidoreductase activity
L	0020037	molecular_function	heme binding
L	0042542	biological_process	response to hydrogen peroxide
L	0042744	biological_process	hydrogen peroxide catabolic process
L	0046872	molecular_function	metal ion binding
L	0098869	biological_process	cellular oxidant detoxification
M	0000302	biological_process	response to reactive oxygen species
M	0004096	molecular_function	catalase activity
M	0004601	molecular_function	peroxidase activity
M	0005737	cellular_component	cytoplasm
M	0005739	cellular_component	mitochondrion
M	0005777	cellular_component	peroxisome
M	0005782	cellular_component	peroxisomal matrix
M	0006979	biological_process	response to oxidative stress
M	0016491	molecular_function	oxidoreductase activity
M	0020037	molecular_function	heme binding
M	0042542	biological_process	response to hydrogen peroxide
M	0042744	biological_process	hydrogen peroxide catabolic process
M	0046872	molecular_function	metal ion binding
M	0098869	biological_process	cellular oxidant detoxification
N	0000302	biological_process	response to reactive oxygen species
N	0004096	molecular_function	catalase activity
N	0004601	molecular_function	peroxidase activity
N	0005737	cellular_component	cytoplasm
N	0005739	cellular_component	mitochondrion
N	0005777	cellular_component	peroxisome
N	0005782	cellular_component	peroxisomal matrix
N	0006979	biological_process	response to oxidative stress
N	0016491	molecular_function	oxidoreductase activity
N	0020037	molecular_function	heme binding
N	0042542	biological_process	response to hydrogen peroxide
N	0042744	biological_process	hydrogen peroxide catabolic process
N	0046872	molecular_function	metal ion binding
N	0098869	biological_process	cellular oxidant detoxification
O	0000302	biological_process	response to reactive oxygen species
O	0004096	molecular_function	catalase activity
O	0004601	molecular_function	peroxidase activity
O	0005737	cellular_component	cytoplasm
O	0005739	cellular_component	mitochondrion
O	0005777	cellular_component	peroxisome
O	0005782	cellular_component	peroxisomal matrix
O	0006979	biological_process	response to oxidative stress
O	0016491	molecular_function	oxidoreductase activity
O	0020037	molecular_function	heme binding
O	0042542	biological_process	response to hydrogen peroxide
O	0042744	biological_process	hydrogen peroxide catabolic process
O	0046872	molecular_function	metal ion binding
O	0098869	biological_process	cellular oxidant detoxification
P	0000302	biological_process	response to reactive oxygen species
P	0004096	molecular_function	catalase activity
P	0004601	molecular_function	peroxidase activity
P	0005737	cellular_component	cytoplasm
P	0005739	cellular_component	mitochondrion
P	0005777	cellular_component	peroxisome
P	0005782	cellular_component	peroxisomal matrix
P	0006979	biological_process	response to oxidative stress
P	0016491	molecular_function	oxidoreductase activity
P	0020037	molecular_function	heme binding
P	0042542	biological_process	response to hydrogen peroxide
P	0042744	biological_process	hydrogen peroxide catabolic process
P	0046872	molecular_function	metal ion binding
P	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEM B 1503

Chain	Residue
B	ARG62
B	PRO148
B	PHE151
B	HIS208
B	PHE324
B	VAL340
B	SER343
B	ARG344
B	SER347
B	TYR348
B	THR351
B	VAL63
B	HIS352
B	ARG355
B	VAL64
B	HIS65
B	ARG102
B	GLY121
B	PHE122
B	TYR137
B	ASN138

site_id	AC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE HEM C 1503

Chain	Residue
B	ASP55
C	ARG62
C	VAL63
C	VAL64
C	HIS65
C	ARG102
C	GLY121
C	VAL136
C	TYR137
C	ASN138
C	PRO148
C	PHE151
C	PHE324
C	VAL340
C	SER343
C	ARG344
C	SER347
C	TYR348
C	THR351
C	HIS352
C	ARG355
C	HOH2004

site_id	AC3
Number of Residues	23
Details	BINDING SITE FOR RESIDUE HEM D 1503

Chain	Residue
D	ARG62
D	VAL63
D	VAL64
D	HIS65
D	ARG102
D	GLY121
D	PHE122
D	VAL136
D	TYR137
D	ASN138
D	PHE143
D	PRO148
D	PHE151
D	PHE324
D	VAL340
D	SER343
D	ARG344
D	SER347
D	TYR348
D	THR351
D	HIS352
D	ARG355
D	HOH2005

site_id	AC4
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEM E 1503

Chain	Residue
E	ARG62
E	VAL63
E	VAL64
E	HIS65
E	ARG102
E	GLY121
E	VAL136
E	TYR137
E	ASN138
E	PRO148
E	PHE151
E	PHE324
E	VAL340
E	SER343
E	ARG344
E	SER347
E	TYR348
E	HIS352
E	ARG355
E	HOH2001
H	ASP55

site_id	AC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE HEM F 1503

Chain	Residue
F	LEU289
F	PHE324
F	SER343
F	ARG344
F	SER347
F	TYR348
F	THR351
F	HIS352
F	ARG355
F	HOH2002
F	ARG62
F	VAL63
F	VAL64
F	HIS65
F	ARG102
F	GLY121
F	PHE122
F	VAL136
F	TYR137
F	ASN138
F	PRO148
F	PHE151

site_id	AC6
Number of Residues	23
Details	BINDING SITE FOR RESIDUE HEM G 1503

Chain	Residue
G	ARG62
G	VAL63
G	VAL64
G	HIS65
G	ARG102
G	GLY121
G	PHE122
G	VAL136
G	TYR137
G	ASN138
G	PHE151
G	LEU289
G	PHE324
G	VAL340
G	SER343
G	ARG344
G	SER347
G	TYR348
G	THR351
G	HIS352
G	ARG355
G	HOH2002
G	HOH2003

site_id	AC7
Number of Residues	23
Details	BINDING SITE FOR RESIDUE HEM H 1503

Chain	Residue
H	ARG62
H	VAL63
H	VAL64
H	HIS65
H	ARG102
H	GLY121
H	PHE122
H	VAL136
H	TYR137
H	ASN138
H	PRO148
H	PHE151
H	HIS208
H	LEU289
H	PHE324
H	VAL340
H	SER343
H	ARG344
H	SER347
H	TYR348
H	THR351
H	HIS352
H	ARG355

site_id	AC8
Number of Residues	22
Details	BINDING SITE FOR RESIDUE HEM I 1503

Chain	Residue
I	ARG62
I	VAL63
I	VAL64
I	HIS65
I	ARG102
I	GLY121
I	PHE122
I	VAL136
I	TYR137
I	ASN138
I	PHE151
I	HIS208
I	PHE324
I	SER343
I	ARG344
I	SER347
I	TYR348
I	THR351
I	HIS352
I	ARG355
I	HOH2004
L	ASP55

site_id	AC9
Number of Residues	25
Details	BINDING SITE FOR RESIDUE HEM J 1503

Chain	Residue
J	ARG62
J	VAL63
J	VAL64
J	HIS65
J	ARG102
J	GLY121
J	PHE122
J	VAL136
J	TYR137
J	ASN138
J	PRO148
J	PHE151
J	SER206
J	HIS208
J	LEU289
J	PHE324
J	VAL340
J	SER343
J	ARG344
J	SER347
J	TYR348
J	THR351
J	HIS352
J	ARG355
K	ASP55

site_id	BC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE HEM K 1503

Chain	Residue
J	ASP55
K	ARG62
K	VAL63
K	VAL64
K	HIS65
K	ARG102
K	GLY121
K	PHE122
K	VAL136
K	TYR137
K	ASN138
K	PRO148
K	PHE151
K	LEU289
K	PHE324
K	VAL340
K	SER343
K	ARG344
K	SER347
K	TYR348
K	THR351
K	HIS352
K	ARG355

site_id	BC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEM L 1503

Chain	Residue
L	ARG62
L	VAL63
L	VAL64
L	HIS65
L	ARG102
L	GLY121
L	PHE122
L	VAL136
L	TYR137
L	ASN138
L	PHE151
L	LEU289
L	PHE324
L	SER343
L	ARG344
L	SER347
L	TYR348
L	THR351
L	HIS352
L	ARG355

site_id	BC3
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEM M 1503

Chain	Residue
M	ARG62
M	VAL64
M	HIS65
M	ARG102
M	GLY121
M	PHE122
M	VAL136
M	TYR137
M	ASN138
M	PHE151
M	HIS208
M	LEU289
M	PHE324
M	SER343
M	ARG344
M	SER347
M	TYR348
M	THR351
M	HIS352
M	ARG355
M	HOH2001

site_id	BC4
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEM N 1503

Chain	Residue
N	ARG62
N	VAL63
N	VAL64
N	HIS65
N	ARG102
N	GLY121
N	VAL136
N	TYR137
N	ASN138
N	PHE151
N	LEU289
N	PHE324
N	VAL340
N	SER343
N	ARG344
N	SER347
N	TYR348
N	THR351
N	HIS352
N	ARG355
O	ASP55

site_id	BC5
Number of Residues	24
Details	BINDING SITE FOR RESIDUE HEM O 1503

Chain	Residue
N	ASP55
O	ARG62
O	VAL63
O	VAL64
O	HIS65
O	ARG102
O	GLY121
O	VAL136
O	TYR137
O	ASN138
O	PRO148
O	PHE151
O	HIS208
O	LEU289
O	PHE324
O	VAL340
O	SER343
O	ARG344
O	SER347
O	TYR348
O	THR351
O	HIS352
O	ARG355
O	HOH2006

site_id	BC6
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEM P 1503

Chain	Residue
P	ARG62
P	VAL63
P	VAL64
P	HIS65
P	ARG102
P	GLY121
P	PHE122
P	VAL136
P	TYR137
P	ASN138
P	PHE151
P	HIS208
P	PHE324
P	SER343
P	ARG344
P	SER347
P	TYR348
P	THR351
P	HIS352
P	ARG355

Functional Information from PROSITE/UniProt

site_id	PS00437
Number of Residues	9
Details	CATALASE_1 Catalase proximal heme-ligand signature. RLFSYpDTH

Chain	Residue	Details
A	ARG344-HIS352

site_id	PS00438
Number of Residues	17
Details	CATALASE_2 Catalase proximal active site signature. FdReripERvvHakGAG

Chain	Residue	Details
A	PHE54-GLY70

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10013","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"UniProtKB","id":"P04040","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)