2XNM

Structure of NEK2 bound to CCT

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE WGZ A 1280

Chain	Residue
A	ILE14
A	ALA145
A	PHE148
A	GLY158
A	ASP159
A	LEU162
A	LEU166
A	HOH2245
A	GLY15
A	CYS22
A	LYS37
A	GLU87
A	TYR88
A	CYS89
A	ASP93
A	SER96

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1281

Chain	Residue
A	LEU11
A	LYS152
A	GLN153
A	HOH2241
A	HOH2246
A	HOH2247

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1282

Chain	Residue
A	ILE247
A	GLU264
A	ASN268

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1283

Chain	Residue
A	ASP242
A	GLU243
A	GLU246
A	HIS277
A	HIS279
A	HOH2249

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1284

Chain	Residue
A	TYR238
A	ARG239
A	SER241
A	HOH2250
A	HOH2251
A	HOH2252

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1285

Chain	Residue
A	TYR12
A	ARG115
A	GLN153

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1286

Chain	Residue
A	ARG234
A	ARG235
A	TYR238
A	LEU266
A	HOH2230
A	HOH2254
A	HOH2255

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1287

Chain	Residue
A	TYR181
A	TYR182
A	GLU208
A	PRO214
A	HOH2257
A	HOH2258

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1288

Chain	Residue
A	GLU195
A	LYS196
A	SER261
A	VAL262
A	HOH2223
A	HOH2259

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1290

Chain	Residue
A	GLU110
A	ARG239

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1292

Chain	Residue
A	ASN154
A	HIS277
A	HOH2150

---

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE TRS A 1291

Chain	Residue
A	HIS128
A	ARG130
A	TYR193
A	ASN194
A	GLU195
A	ASP198
A	HOH2260

---

Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpaNVFL

Chain	Residue	Details
A	VAL137-LEU149

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"PubMed","id":"17197699","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"PubMed","id":"17197699","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---