Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2XKX

Single particle analysis of PSD-95 in negative stain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002091	biological_process	negative regulation of receptor internalization
A	0005102	molecular_function	signaling receptor binding
A	0005109	molecular_function	frizzled binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005911	cellular_component	cell-cell junction
A	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
A	0007268	biological_process	chemical synaptic transmission
A	0007399	biological_process	nervous system development
A	0008021	cellular_component	synaptic vesicle
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0014069	cellular_component	postsynaptic density
A	0016020	cellular_component	membrane
A	0016188	biological_process	synaptic vesicle maturation
A	0019894	molecular_function	kinesin binding
A	0019901	molecular_function	protein kinase binding
A	0019903	molecular_function	protein phosphatase binding
A	0021700	biological_process	developmental maturation
A	0021987	biological_process	cerebral cortex development
A	0030054	cellular_component	cell junction
A	0030165	molecular_function	PDZ domain binding
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0031594	cellular_component	neuromuscular junction
A	0031697	molecular_function	beta-1 adrenergic receptor binding
A	0031698	molecular_function	beta-2 adrenergic receptor binding
A	0031748	molecular_function	D1 dopamine receptor binding
A	0031812	molecular_function	P2Y1 nucleotide receptor binding
A	0032281	cellular_component	AMPA glutamate receptor complex
A	0032839	cellular_component	dendrite cytoplasm
A	0033130	molecular_function	acetylcholine receptor binding
A	0035176	biological_process	social behavior
A	0035254	molecular_function	glutamate receptor binding
A	0035255	molecular_function	ionotropic glutamate receptor binding
A	0035418	biological_process	protein localization to synapse
A	0035641	biological_process	locomotory exploration behavior
A	0043005	cellular_component	neuron projection
A	0043197	cellular_component	dendritic spine
A	0043226	cellular_component	organelle
A	0044224	cellular_component	juxtaparanode region of axon
A	0044306	cellular_component	neuron projection terminus
A	0044307	cellular_component	dendritic branch
A	0044309	cellular_component	neuron spine
A	0044877	molecular_function	protein-containing complex binding
A	0045161	biological_process	neuronal ion channel clustering
A	0045184	biological_process	establishment of protein localization
A	0045202	cellular_component	synapse
A	0045211	cellular_component	postsynaptic membrane
A	0048168	biological_process	regulation of neuronal synaptic plasticity
A	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
A	0050775	biological_process	positive regulation of dendrite morphogenesis
A	0050806	biological_process	positive regulation of synaptic transmission
A	0050885	biological_process	neuromuscular process controlling balance
A	0051965	biological_process	positive regulation of synapse assembly
A	0060076	cellular_component	excitatory synapse
A	0060997	biological_process	dendritic spine morphogenesis
A	0065003	biological_process	protein-containing complex assembly
A	0071625	biological_process	vocalization behavior
A	0072657	biological_process	protein localization to membrane
A	0097060	cellular_component	synaptic membrane
A	0097061	biological_process	dendritic spine organization
A	0097109	molecular_function	neuroligin family protein binding
A	0097110	molecular_function	scaffold protein binding
A	0097113	biological_process	AMPA glutamate receptor clustering
A	0097120	biological_process	receptor localization to synapse
A	0098609	biological_process	cell-cell adhesion
A	0098793	cellular_component	presynapse
A	0098839	cellular_component	postsynaptic density membrane
A	0098919	molecular_function	structural constituent of postsynaptic density
A	0098978	cellular_component	glutamatergic synapse
A	0098989	biological_process	NMDA selective glutamate receptor signaling pathway
A	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
A	0099562	biological_process	maintenance of postsynaptic density structure
A	0150012	biological_process	positive regulation of neuron projection arborization
A	1904719	biological_process	positive regulation of AMPA glutamate receptor clustering
A	1990635	cellular_component	proximal dendrite
A	2000310	biological_process	regulation of NMDA receptor activity
A	2000463	biological_process	positive regulation of excitatory postsynaptic potential
A	2000821	biological_process	regulation of grooming behavior
B	0002091	biological_process	negative regulation of receptor internalization
B	0005102	molecular_function	signaling receptor binding
B	0005109	molecular_function	frizzled binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005911	cellular_component	cell-cell junction
B	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
B	0007268	biological_process	chemical synaptic transmission
B	0007399	biological_process	nervous system development
B	0008021	cellular_component	synaptic vesicle
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0014069	cellular_component	postsynaptic density
B	0016020	cellular_component	membrane
B	0016188	biological_process	synaptic vesicle maturation
B	0019894	molecular_function	kinesin binding
B	0019901	molecular_function	protein kinase binding
B	0019903	molecular_function	protein phosphatase binding
B	0021700	biological_process	developmental maturation
B	0021987	biological_process	cerebral cortex development
B	0030054	cellular_component	cell junction
B	0030165	molecular_function	PDZ domain binding
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0031594	cellular_component	neuromuscular junction
B	0031697	molecular_function	beta-1 adrenergic receptor binding
B	0031698	molecular_function	beta-2 adrenergic receptor binding
B	0031748	molecular_function	D1 dopamine receptor binding
B	0031812	molecular_function	P2Y1 nucleotide receptor binding
B	0032281	cellular_component	AMPA glutamate receptor complex
B	0032839	cellular_component	dendrite cytoplasm
B	0033130	molecular_function	acetylcholine receptor binding
B	0035176	biological_process	social behavior
B	0035254	molecular_function	glutamate receptor binding
B	0035255	molecular_function	ionotropic glutamate receptor binding
B	0035418	biological_process	protein localization to synapse
B	0035641	biological_process	locomotory exploration behavior
B	0043005	cellular_component	neuron projection
B	0043197	cellular_component	dendritic spine
B	0043226	cellular_component	organelle
B	0044224	cellular_component	juxtaparanode region of axon
B	0044306	cellular_component	neuron projection terminus
B	0044307	cellular_component	dendritic branch
B	0044309	cellular_component	neuron spine
B	0044877	molecular_function	protein-containing complex binding
B	0045161	biological_process	neuronal ion channel clustering
B	0045184	biological_process	establishment of protein localization
B	0045202	cellular_component	synapse
B	0045211	cellular_component	postsynaptic membrane
B	0048168	biological_process	regulation of neuronal synaptic plasticity
B	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
B	0050775	biological_process	positive regulation of dendrite morphogenesis
B	0050806	biological_process	positive regulation of synaptic transmission
B	0050885	biological_process	neuromuscular process controlling balance
B	0051965	biological_process	positive regulation of synapse assembly
B	0060076	cellular_component	excitatory synapse
B	0060997	biological_process	dendritic spine morphogenesis
B	0065003	biological_process	protein-containing complex assembly
B	0071625	biological_process	vocalization behavior
B	0072657	biological_process	protein localization to membrane
B	0097060	cellular_component	synaptic membrane
B	0097061	biological_process	dendritic spine organization
B	0097109	molecular_function	neuroligin family protein binding
B	0097110	molecular_function	scaffold protein binding
B	0097113	biological_process	AMPA glutamate receptor clustering
B	0097120	biological_process	receptor localization to synapse
B	0098609	biological_process	cell-cell adhesion
B	0098793	cellular_component	presynapse
B	0098839	cellular_component	postsynaptic density membrane
B	0098919	molecular_function	structural constituent of postsynaptic density
B	0098978	cellular_component	glutamatergic synapse
B	0098989	biological_process	NMDA selective glutamate receptor signaling pathway
B	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
B	0099562	biological_process	maintenance of postsynaptic density structure
B	0150012	biological_process	positive regulation of neuron projection arborization
B	1904719	biological_process	positive regulation of AMPA glutamate receptor clustering
B	1990635	cellular_component	proximal dendrite
B	2000310	biological_process	regulation of NMDA receptor activity
B	2000463	biological_process	positive regulation of excitatory postsynaptic potential
B	2000821	biological_process	regulation of grooming behavior

Functional Information from PROSITE/UniProt

site_id	PS00856
Number of Residues	18
Details	GUANYLATE_KINASE_1 Guanylate kinase-like signature. TTRpkReyEidGrdYhFV

Chain	Residue	Details
A	THR563-VAL580

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	172
Details	Domain: {"description":"PDZ 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00143","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	172
Details	Domain: {"description":"PDZ 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00143","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	160
Details	Domain: {"description":"PDZ 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00143","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	140
Details	Domain: {"description":"SH3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00192","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	350
Details	Domain: {"description":"Guanylate kinase-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00100","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	40
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q62108","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q62108","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"10629226","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27307232","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)