2XKR

Crystal Structure of Mycobacterium tuberculosis CYP142: A novel cholesterol oxidase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0006707	biological_process	cholesterol catabolic process
A	0008395	molecular_function	steroid hydroxylase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0020037	molecular_function	heme binding
A	0031073	molecular_function	cholesterol 26-hydroxylase activity
A	0036199	molecular_function	cholest-4-en-3-one 26-monooxygenase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PG4 A 1399

Chain	Residue
A	LEU163
A	LEU226
A	GLY230
A	HEM1400

---

site_id	AC2
Number of Residues	24
Details	BINDING SITE FOR RESIDUE HEM A 1400

Chain	Residue
A	PHE94
A	ILE227
A	GLY230
A	GLY231
A	THR234
A	THR235
A	THR238
A	VAL277
A	ARG282
A	ALA332
A	PHE333
A	GLY334
A	PHE335
A	THR337
A	HIS338
A	CYS340
A	GLY342
A	PG41399
A	HOH2510
A	GLU53
A	MET75
A	ILE76
A	HIS83
A	ARG87

---

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGfGTHFCLG

Chain	Residue	Details
A	PHE333-GLY342

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"UniProtKB","id":"P9WPL5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"20889498","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XKR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---