2XKR
Crystal Structure of Mycobacterium tuberculosis CYP142: A novel cholesterol oxidase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006707 | biological_process | cholesterol catabolic process |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0008203 | biological_process | cholesterol metabolic process |
| A | 0008395 | molecular_function | steroid hydroxylase activity |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0020037 | molecular_function | heme binding |
| A | 0031073 | molecular_function | cholesterol 26-hydroxylase activity |
| A | 0036199 | molecular_function | cholest-4-en-3-one 26-monooxygenase activity |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PG4 A 1399 |
| Chain | Residue |
| A | LEU163 |
| A | LEU226 |
| A | GLY230 |
| A | HEM1400 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE HEM A 1400 |
| Chain | Residue |
| A | PHE94 |
| A | ILE227 |
| A | GLY230 |
| A | GLY231 |
| A | THR234 |
| A | THR235 |
| A | THR238 |
| A | VAL277 |
| A | ARG282 |
| A | ALA332 |
| A | PHE333 |
| A | GLY334 |
| A | PHE335 |
| A | THR337 |
| A | HIS338 |
| A | CYS340 |
| A | GLY342 |
| A | PG41399 |
| A | HOH2510 |
| A | GLU53 |
| A | MET75 |
| A | ILE76 |
| A | HIS83 |
| A | ARG87 |
Functional Information from PROSITE/UniProt
| site_id | PS00086 |
| Number of Residues | 10 |
| Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGfGTHFCLG |
| Chain | Residue | Details |
| A | PHE333-GLY342 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"20889498","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XKR","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
