2XJD

Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with inorganic phosphate and deoxyadenosine triphosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000255	biological_process	allantoin metabolic process
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006202	biological_process	GMP catabolic process to guanine
A	0006204	biological_process	IMP catabolic process
A	0008253	molecular_function	5'-nucleotidase activity
A	0009117	biological_process	nucleotide metabolic process
A	0016740	molecular_function	transferase activity
A	0016787	molecular_function	hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0043605	biological_process	amide catabolic process
A	0046037	biological_process	GMP metabolic process
A	0046038	biological_process	GMP catabolic process
A	0046040	biological_process	IMP metabolic process
A	0046054	biological_process	dGMP metabolic process
A	0046055	biological_process	dGMP catabolic process
A	0046085	biological_process	adenosine metabolic process
A	0046872	molecular_function	metal ion binding
A	0050146	molecular_function	nucleoside phosphotransferase activity
A	0050689	biological_process	negative regulation of defense response to virus by host
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0070936	biological_process	protein K48-linked ubiquitination
A	0140374	biological_process	antiviral innate immune response

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ATP A 1489

Chain	Residue
A	ARG144
A	MG1498
A	MG1498
A	HOH2175
A	HOH2176
A	HOH2381
A	HOH2382
A	HOH2438
A	HOH2439
A	HOH2440
A	HOH2441
A	ASP145
A	HOH2442
A	HOH2443
A	HOH2444
A	ASN154
A	PHE354
A	LYS362
A	GLN453
A	ARG456
A	ARG456
A	TYR457

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1490

Chain	Residue
A	HIS209
A	TYR210
A	LYS215
A	SER251
A	TYR255
A	GOL1493
A	HOH2445

---

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 1491

Chain	Residue
A	PHE283
A	ASP284
A	ILE286
A	LEU321
A	GLN322
A	HIS323
A	GLY324
A	ILE325
A	HOH2353
A	HOH2446
A	HOH2447

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1492

Chain	Residue
A	PHE198
A	GLN199
A	ARG202
A	HOH2188
A	HOH2231
A	HOH2449

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1493

Chain	Residue
A	PHE157
A	ARG202
A	VAL205
A	ASP206
A	TYR210
A	GOL1490

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 1494

Chain	Residue
A	PRO96
A	GLU374
A	GLU378
A	TYR434
A	HOH2391
A	HOH2451
A	HOH2453
A	HOH2454
A	HOH2455

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1495

Chain	Residue
A	ASP257
A	THR261
A	PRO278
A	TRP279
A	GLN280
A	HOH2456
A	HOH2457

---

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PO4 A 1496

Chain	Residue
A	ASN52
A	MET53
A	ASP54
A	THR249
A	ASN250
A	SER251
A	LYS292
A	MG1497
A	HOH2372
A	HOH2374
A	HOH2445
A	HOH2458

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1497

Chain	Residue
A	ASN52
A	ASP54
A	ASP351
A	PO41496
A	HOH2372
A	HOH2374

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1498

Chain	Residue
A	LYS362
A	ATP1489
A	ATP1489
A	HOH2381
A	HOH2381

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17405878","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2J2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JCM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XCV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XCW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XJB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XJC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XJD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XJE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XJB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XJC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XCV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XCW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17405878","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2J2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JCM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17405878","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2JC9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---