Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2XEW

Crystal structure of K11-linked diubiquitin

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1077

Chain	Residue
A	VAL70
A	LEU71
G	THR7
G	THR9
G	LYS11
G	HOH2045

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1078

Chain	Residue
G	VAL70
G	LEU71
G	HOH2045
A	THR7
A	THR9
A	LYS11

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO A 1079

Chain	Residue
A	PHE45
A	SER65
A	THR66
K	ILE44
K	PHE45
K	ALA46
K	GLY47
K	HIS68
K	HOH2057

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1080

Chain	Residue
A	GLU16
A	LYS33
D	HOH2051

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 1077

Chain	Residue
B	VAL70
B	LEU71
F	THR7
F	THR9
F	LYS11
F	EDO1079

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO B 1078

Chain	Residue
A	GLU18
A	PRO19
A	SER20
B	GLU18
B	SER20
B	HOH2055
B	HOH2056

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO B 1079

Chain	Residue
A	GLY53
B	LEU15
B	GLU16
B	LYS29
B	LYS33
B	HOH2024
B	HOH2057
B	HOH2058
B	HOH2059

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO C 1075

Chain	Residue
C	LEU15
C	GLU16
C	LYS29
C	LYS33
C	HOH2057

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 1076

Chain	Residue
C	GLN2
C	LYS63

site_id	BC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EDO D 1077

Chain	Residue
D	PHE45
D	SER65
D	THR66
D	HOH2068
L	ILE44
L	PHE45
L	ALA46
L	GLY47
L	HIS68
L	HOH2054

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 1078

Chain	Residue
D	GLU16
D	LYS33

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO E 1077

Chain	Residue
C	THR7
C	THR9
E	VAL70
E	LEU71

site_id	BC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE FLC F 1077

Chain	Residue
A	PRO37
A	ASP39
A	GLN40
A	ARG74
B	GLY35
B	PRO37
F	PRO37
F	ASP39
F	GLN40
F	ARG74
F	FLC1078

site_id	BC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE FLC F 1078

Chain	Residue
B	ASP39
B	GLN40
B	ARG74
E	PRO37
E	ASP39
E	GLN40
E	ARG74
F	GLY35
F	PRO37
F	FLC1077
F	HOH2010
F	HOH2026

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO F 1079

Chain	Residue
B	THR7
B	THR9
B	LYS11
B	EDO1077
F	VAL70
F	LEU71

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO H 1077

Chain	Residue
D	LEU71
H	THR7
H	THR9
H	LYS11
H	HOH2051
D	VAL70

site_id	BC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO I 1077

Chain	Residue
C	PHE45
C	SER65
C	THR66
C	HOH2055
I	ILE44
I	PHE45
I	ALA46
I	GLY47
I	HIS68

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL I 1078

Chain	Residue
I	ARG42
I	HOH2050

site_id	CC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO J 1077

Chain	Residue
B	PHE45
B	SER65
B	THR66
J	PHE45
J	ALA46
J	GLY47
J	HIS68
J	HOH2078

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO K 1077

Chain	Residue
J	THR7
J	THR9
K	VAL70
K	LEU71

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO L 1075

Chain	Residue
I	VAL70
I	LEU71
L	THR7
L	THR9
L	LYS11

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO L 1076

Chain	Residue
I	THR7
I	THR9
I	LYS11
L	VAL70
L	LEU71

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO L 1077

Chain	Residue
L	MET1
L	GLN2
L	THR14
L	LEU15
L	GLU16

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL L 1078

Chain	Residue
L	ASN25
L	ALA28

site_id	CC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL L 1079

Chain	Residue
L	THR14

site_id	CC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL L 1080

Chain	Residue
I	GLU16
I	LYS33
L	HOH2043

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
A	LYS27-ASP52

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	750
Details	Domain: {"description":"Ubiquitin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	24
Details	Site: {"description":"Interacts with activating enzyme"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	12
Details	Site: {"description":"Essential for function"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine; by PINK1","evidences":[{"source":"PubMed","id":"24660806","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24751536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24784582","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25527291","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Modified residue: {"description":"(Microbial infection) ADP-ribosylthreonine","evidences":[{"source":"PubMed","id":"32330457","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	10
Details	Modified residue: {"description":"ADP-ribosylglycine","evidences":[{"source":"PubMed","id":"28525742","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	12
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"16443603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	20
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	24
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"16443603","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16543144","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	12
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"15466860","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	12
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"16543144","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25752573","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25752577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34239127","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	12
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"25752577","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	14
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"16543144","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18719106","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)