2XDV
Crystal Structure of the Catalytic Domain of FLJ14393
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003714 | molecular_function | transcription corepressor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005667 | cellular_component | transcription regulator complex |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005829 | cellular_component | cytosol |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0032452 | molecular_function | histone demethylase activity |
| A | 0032453 | molecular_function | histone H3K4 demethylase activity |
| A | 0036139 | molecular_function | peptidyl-histidine dioxygenase activity |
| A | 0042254 | biological_process | ribosome biogenesis |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051213 | molecular_function | dioxygenase activity |
| A | 0051864 | molecular_function | histone H3K36 demethylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NI A 1466 |
| Chain | Residue |
| A | HIS179 |
| A | ASP181 |
| A | HIS240 |
| A | OGA601 |
| A | HOH2148 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI A 1467 |
| Chain | Residue |
| A | HIS195 |
| A | GLU223 |
| A | ASP243 |
| A | HOH2086 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NI A 1468 |
| Chain | Residue |
| A | HIS337 |
| A | HOH2127 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NI A 1469 |
| Chain | Residue |
| A | HIS423 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NI A 1470 |
| Chain | Residue |
| A | ASP129 |
| A | HIS138 |
| A | HOH2024 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NI A 1471 |
| Chain | Residue |
| A | HIS415 |
| A | GLU459 |
| A | HOH2146 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MN A 1472 |
| Chain | Residue |
| A | ASP69 |
| A | ASP69 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE OGA A 601 |
| Chain | Residue |
| A | TYR167 |
| A | GLY175 |
| A | LEU176 |
| A | HIS179 |
| A | ASP181 |
| A | LYS194 |
| A | HIS240 |
| A | HIS253 |
| A | THR255 |
| A | NI1466 |
| A | HOH2043 |
| A | HOH2148 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1474 |
| Chain | Residue |
| A | PHE143 |
| A | LYS144 |
| A | ASP145 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1475 |
| Chain | Residue |
| A | GLU57 |
| A | GLN61 |
| A | LYS62 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CD A 1476 |
| Chain | Residue |
| A | CYS156 |
| A | ASP370 |
| A | HIS371 |
| A | HOH2057 |
| A | HOH2133 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CD A 1477 |
| Chain | Residue |
| A | CYS460 |
| A | HOH2021 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CD A 1478 |
| Chain | Residue |
| A | CYS90 |
| A | CYS460 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| A | HIS179 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00538 |
| Chain | Residue | Details |
| A | ASP181 | |
| A | HIS240 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | SER309 |
