2XD4

Nucleotide-bound Structures of Bacillus subtilis Glycinamide Ribonucleotide Synthetase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004637	molecular_function	phosphoribosylamine-glycine ligase activity
A	0005524	molecular_function	ATP binding
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0009113	biological_process	purine nucleobase biosynthetic process
A	0016874	molecular_function	ligase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ADP A 461

Chain	Residue
A	LYS103
A	LYS214
A	MET273
A	ILE282
A	GLU283
A	MG451
A	MG453
A	HOH2070
A	HOH2071
A	VAL141
A	LYS143
A	GLY150
A	VAL153
A	GLU185
A	GLU186
A	LEU188
A	GLU192

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 451

Chain	Residue
A	GLU283
A	ASN285
A	ADP461
A	HOH2070

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 452

Chain	Residue
A	HIS167
A	ASP172
A	HOH2038

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 453

Chain	Residue
A	LYS214
A	GLU283
A	ADP461

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Functional Information from PROSITE/UniProt

site_id	PS00184
Number of Residues	8
Details	GARS Phosphoribosylglycinamide synthetase signature. RFGDPEtQ

Chain	Residue	Details
A	ARG287-GLN294

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	206
Details	Domain: {"description":"ATP-grasp","evidences":[{"source":"HAMAP-Rule","id":"MF_00138","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	63
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00138","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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