2XBM
Crystal structure of the dengue virus methyltransferase bound to a 5'- capped octameric RNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| A | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| B | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| B | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0032259 | biological_process | methylation |
| C | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| C | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0032259 | biological_process | methylation |
| D | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| D | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
| D | 0008168 | molecular_function | methyltransferase activity |
| D | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 264 |
| Chain | Residue |
| A | ARG38 |
| A | LYS42 |
| A | ARG57 |
| A | ARG84 |
| A | HOH2093 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 265 |
| Chain | Residue |
| A | ARG76 |
| A | ARG101 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 266 |
| Chain | Residue |
| A | ARG236 |
| A | HOH2094 |
| A | SER229 |
| A | ASN232 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 267 |
| Chain | Residue |
| A | LYS29 |
| A | LYS30 |
| A | ARG211 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE SAH A 268 |
| Chain | Residue |
| A | SER56 |
| A | GLY58 |
| A | GLY81 |
| A | CYS82 |
| A | GLY83 |
| A | GLY86 |
| A | TRP87 |
| A | THR104 |
| A | LYS105 |
| A | LYS130 |
| A | ASP131 |
| A | VAL132 |
| A | PHE133 |
| A | ASP146 |
| A | HOH2095 |
| A | HOH2096 |
| A | HOH2097 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL A 269 |
| Chain | Residue |
| A | LYS61 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 264 |
| Chain | Residue |
| B | GLY109 |
| B | HIS110 |
| B | GLU111 |
| B | SAH268 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 265 |
| Chain | Residue |
| B | ARG38 |
| B | LYS42 |
| B | ARG57 |
| B | ARG84 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 266 |
| Chain | Residue |
| B | ARG76 |
| B | ARG101 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 267 |
| Chain | Residue |
| B | SER229 |
| B | ASN232 |
| B | ARG236 |
| D | LYS15 |
| site_id | BC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE SAH B 268 |
| Chain | Residue |
| B | SER56 |
| B | GLY58 |
| B | GLY81 |
| B | CYS82 |
| B | GLY86 |
| B | TRP87 |
| B | THR104 |
| B | LYS105 |
| B | LYS130 |
| B | ASP131 |
| B | VAL132 |
| B | PHE133 |
| B | ASP146 |
| B | SO4264 |
| B | HOH2050 |
| B | HOH2063 |
| B | HOH2117 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 269 |
| Chain | Residue |
| B | LYS61 |
| B | LEU209 |
| B | SER210 |
| B | ARG211 |
| B | HOH2118 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 264 |
| Chain | Residue |
| C | GLY109 |
| C | HIS110 |
| C | GLU111 |
| C | SAH266 |
| C | HOH2117 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 265 |
| Chain | Residue |
| C | ARG38 |
| C | LYS42 |
| C | ARG57 |
| C | ARG84 |
| site_id | BC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE SAH C 266 |
| Chain | Residue |
| C | SER56 |
| C | GLY58 |
| C | GLY81 |
| C | CYS82 |
| C | GLY86 |
| C | TRP87 |
| C | LYS105 |
| C | LYS130 |
| C | ASP131 |
| C | VAL132 |
| C | PHE133 |
| C | ASP146 |
| C | SO4264 |
| C | HOH2038 |
| C | HOH2047 |
| C | HOH2118 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 264 |
| Chain | Residue |
| D | GLY109 |
| D | HIS110 |
| D | GLU111 |
| D | SAH266 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 265 |
| Chain | Residue |
| D | ARG57 |
| D | ARG84 |
| D | ARG38 |
| D | LYS42 |
| site_id | BC9 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE SAH D 266 |
| Chain | Residue |
| D | SER56 |
| D | GLY58 |
| D | GLY81 |
| D | CYS82 |
| D | GLY86 |
| D | TRP87 |
| D | LYS105 |
| D | LYS130 |
| D | ASP131 |
| D | VAL132 |
| D | PHE133 |
| D | ASP146 |
| D | SO4264 |
| D | HOH2102 |
| D | HOH2103 |
