2XA0

Crystal structure of BCL-2 in complex with a BAX BH3 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane
A	0042981	biological_process	regulation of apoptotic process
A	0043066	biological_process	negative regulation of apoptotic process
B	0016020	cellular_component	membrane
B	0042981	biological_process	regulation of apoptotic process
B	0043066	biological_process	negative regulation of apoptotic process
C	0042981	biological_process	regulation of apoptotic process
D	0042981	biological_process	regulation of apoptotic process

Functional Information from PROSITE/UniProt

site_id	PS01080
Number of Residues	19
Details	BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFeFGG

Chain	Residue	Details
A	LEU137-GLY155

---

site_id	PS01258
Number of Residues	12
Details	BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqdnGGWDaFV

Chain	Residue	Details
A	TRP188-VAL199

---

site_id	PS01259
Number of Residues	15
Details	BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. LsecLRrIGDELDSN

Chain	Residue	Details
C	LEU59-ASN73
A	VAL93-ARG107

---

site_id	PS01260
Number of Residues	21
Details	BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. DNREIVmKYIHYKLSQRGYeW

Chain	Residue	Details
A	ASP10-TRP30

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Region: {"description":"Required for interaction with SEPTIN4 isoform ARTS. Required XIAP-mediated ubiquitination and apoptosis","evidences":[{"source":"PubMed","id":"29020630","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	40
Details	Motif: {"description":"BH4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00025","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	28
Details	Motif: {"description":"BH3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	38
Details	Motif: {"description":"BH1","evidences":[{"evidenceCode":"ECO:0000255"}]}

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Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	30
Details	Motif: {"description":"BH2","evidences":[{"evidenceCode":"ECO:0000255"}]}

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Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	28
Details	Motif: {"description":"BH3"}

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Residue

Details

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